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公开(公告)号：US20050272661A1
公开(公告)日：2005-12-08
申请号：US11178269
申请日：2005-07-08
申请人： Elliott Richelson , Bernadette Cusack , Yuan-Ping Pang , Daniel McCormick , Abdul Fauq , Beth Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Cusack , Yuan-Ping Pang , Daniel McCormick , Abdul Fauq , Beth Tyler , Mona Boules
IPC分类号： A61K38/00 , A61K38/08 , A61K38/10 , C07D209/08 , C07D209/18 , C07K7/06 , C07K7/08 , C07K7/14 , C07K7/18 , C07K14/70
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
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公开(公告)号：US20070173458A1
公开(公告)日：2007-07-26
申请号：US11452616
申请日：2006-06-14
申请人： Elliott Richelson , Bernadette Cusack , Yuan-Ping Pang , Daniel McCormick , Abdul Fauq , Beth Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Cusack , Yuan-Ping Pang , Daniel McCormick , Abdul Fauq , Beth Tyler , Mona Boules
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
摘要翻译： 本发明提供了新的氨基酸，新色氨酸，以及含有这种新型氨基酸的多肽，如神经降压素类似物。 此外，本发明提供新色氨酸衍生物，5-羟色胺样新色氨酸衍生物和含有这些衍生物的多肽。 本发明还提供了制备新色氨酸，新色氨酸衍生物，血清素样新色氨酸衍生物和含有这些化合物的组合物的方法。 此外，本发明提供了在哺乳动物中诱导神经降压素反应的方法以及用于治疗具有5-羟色胺识别分子的哺乳动物的方法。
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公开(公告)号：US20100173849A1
公开(公告)日：2010-07-08
申请号：US12651878
申请日：2010-01-04
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L′, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.
摘要翻译： 描述了在人中诱导抗感受伤害的方法。 该方法包括向人以外施用有效剂量的包含L-新色氨酸的多肽的步骤。 含有L-新色氨酸的多肽可以是但不限于NT64L，NT65L，NT66L，NT67L，NT69L，NT69L'，NT71，NT72，NT73，NT74，NT75，NT76或NT77。
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公开(公告)号：US07098307B2
公开(公告)日：2006-08-29
申请号：US11178269
申请日：2005-07-08
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
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公开(公告)号：US20120108519A1
公开(公告)日：2012-05-03
申请号：US13324976
申请日：2011-12-13
申请人： ELLIOTT RICHELSON , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： ELLIOTT RICHELSON , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
IPC分类号： A61K38/08
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L′, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.
摘要翻译： 描述了在人中诱导抗感受伤害的方法。 该方法包括向人以外施用有效剂量的包含L-新色氨酸的多肽的步骤。 含有L-新色氨酸的多肽可以是但不限于NT64L，NT65L，NT66L，NT67L，NT69L，NT69L'，NT71，NT72，NT73，NT74，NT75，NT76或NT77。
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公开(公告)号：US06921805B2
公开(公告)日：2005-07-26
申请号：US10858226
申请日：2004-06-01
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
IPC分类号： A61K38/00 , A61K38/08 , A61K38/10 , C07D209/08 , C07D209/18 , C07K7/06 , C07K7/08 , C07K7/14 , C07K7/18 , C07K14/70
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
摘要翻译： 本发明提供了新的氨基酸，新色氨酸，以及含有这种新型氨基酸的多肽，如神经降压素类似物。 此外，本发明提供新色氨酸衍生物，5-羟色胺样新色氨酸衍生物和含有这些衍生物的多肽。 本发明还提供了制备新色氨酸，新色氨酸衍生物，血清素样新色氨酸衍生物和含有这些化合物的组合物的方法。 此外，本发明提供了在哺乳动物中诱导神经降压素反应的方法以及用于治疗具有5-羟色胺识别分子的哺乳动物的方法。
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公开(公告)号：US06214790B1
公开(公告)日：2001-04-10
申请号：US09289693
申请日：1999-04-09
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
IPC分类号： A61K31405
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
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公开(公告)号：US20130210740A1
公开(公告)日：2013-08-15
申请号：US13590661
申请日：2012-08-21
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
IPC分类号： C07K7/08
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L′, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.
摘要翻译： 描述了在人中诱导抗感受伤害的方法。 该方法包括向人以外施用有效剂量的包含L-新色氨酸的多肽的步骤。 含有L-新色氨酸的多肽可以是但不限于NT64L，NT65L，NT66L，NT67L，NT69L，NT69L'，NT71，NT72，NT73，NT74，NT75，NT76或NT77。
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公开(公告)号：US20110183885A1
公开(公告)日：2011-07-28
申请号：US13077028
申请日：2011-03-31
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L′, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.
摘要翻译： 描述了在人中诱导抗感受伤害的方法。 该方法包括向人以外施用有效剂量的包含L-新色氨酸的多肽的步骤。 含有L-新色氨酸的多肽可以是但不限于NT64L，NT65L，NT66L，NT67L，NT69L，NT69L'，NT71，NT72，NT73，NT74，NT75，NT76或NT77。
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公开(公告)号：US07642231B2
公开(公告)日：2010-01-05
申请号：US11452616
申请日：2006-06-14
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
摘要翻译： 本发明提供了新的氨基酸，新色氨酸，以及含有这种新型氨基酸的多肽，如神经降压素类似物。 此外，本发明提供新色氨酸衍生物，5-羟色胺样新色氨酸衍生物和含有这些衍生物的多肽。 本发明还提供了制备新色氨酸，新色氨酸衍生物，血清素样新色氨酸衍生物和含有这些化合物的组合物的方法。 此外，本发明提供了在哺乳动物中诱导神经降压素反应的方法以及用于治疗具有5-羟色胺识别分子的哺乳动物的方法。
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