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12 条记录 (耗时 0.032 秒)

    Using polyamide nucleic acid oligomers to engender a biological response
    3.
    发明授权
    Using polyamide nucleic acid oligomers to engender a biological response 失效
    使用聚酰胺核酸低聚物产生生物反应

    公开(公告)号：US06989270B1

    公开(公告)日：2006-01-24

    申请号：US09168714

    申请日：1998-10-08

    申请人： Elliott Richelson ,  Beth Marie Tyler ,  Bernadette Marie Cusack ,  Christopher Lee Douglas ,  Karen Jansen

    发明人： Elliott Richelson ,  Beth Marie Tyler ,  Bernadette Marie Cusack ,  Christopher Lee Douglas ,  Karen Jansen

    IPC分类号： C07H21/04 ,  C12N15/00 ,  A61K48/00

    CPC分类号： C07K14/003 ,  A61K38/00 ,  A61K2123/00 ,  C12N15/1138 ,  C12N2310/3181

    摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal. Further, the invention provides methods and materials for screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, the invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.

    摘要翻译： 本发明涉及用于细胞外活细胞的PNA寡聚体的方法和材料。 具体地，本发明提供了用PNA寡聚体处理活细胞的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。 此外，本发明提供了用于向动物口服PNA寡聚体的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。 本发明还提供分别调节转录和翻译的有义和反义PNA寡聚体。 本发明还提供了调节产生的生物反应程度的错配PNA寡聚体。 此外，本发明提供了用于检测从动物收集的生物样品中的PNA寡聚体的方法和材料。 此外，本发明提供了用于筛选潜在的PNA寡聚体以产生序列特异性生物反应的能力的方法和材料。 此外，本发明提供鉴定多肽的功能和确定功能性多肽的相对周转率的方法。

    Using polyamide nucleic acid oligomers to engender a biological response
    4.
    发明授权
    Using polyamide nucleic acid oligomers to engender a biological response 失效
    使用聚酰胺核酸低聚物产生生物反应

    公开(公告)号：US06743627B1

    公开(公告)日：2004-06-01

    申请号：US09016685

    申请日：1998-01-30

    申请人： Elliott Richelson ,  Beth Marie Tyler ,  Daniel J. McCormick ,  Bernadette Marie Cusack ,  Clark V. Hoshall ,  Christopher Lee Douglas ,  Karen Jansen

    发明人： Elliott Richelson ,  Beth Marie Tyler ,  Daniel J. McCormick ,  Bernadette Marie Cusack ,  Clark V. Hoshall ,  Christopher Lee Douglas ,  Karen Jansen

    IPC分类号： C07K2104

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  A61K2123/00 ,  C07K14/003 ,  C12N2310/3181

    摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.

    摘要翻译： 本发明涉及用于细胞外活细胞的PNA寡聚体的方法和材料。 具体地，本发明提供了用PNA寡聚体处理活细胞的方法，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。 此外，本发明提供了用于向动物口服PNA寡聚体的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。 本发明还提供了筛选潜在的PNA寡聚体以产生序列特异性生物反应的能力的方法。 此外，本发明提供鉴定多肽的功能和确定功能性多肽的相对周转率的方法。

    Neo-tryptophan
    8.
    发明授权
    Neo-tryptophan 失效
    新色氨酸

    公开(公告)号：US07642231B2

    公开(公告)日：2010-01-05

    申请号：US11452616

    申请日：2006-06-14

    申请人： Elliott Richelson ,  Bernadette Marie Cusack ,  Yuan-Ping Pang ,  Daniel J. McCormick ,  Abdul Fauq ,  Beth Marie Tyler ,  Mona Boules

    发明人： Elliott Richelson ,  Bernadette Marie Cusack ,  Yuan-Ping Pang ,  Daniel J. McCormick ,  Abdul Fauq ,  Beth Marie Tyler ,  Mona Boules

    IPC分类号： A61K38/02 ,  A61K38/08

    CPC分类号： C07K7/083 ,  A61K38/00 ,  C07D209/08 ,  C07K7/14 ,  C07K7/18 ,  C07K14/70 ,  C07K14/702

    摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.

    摘要翻译： 本发明提供了新的氨基酸，新色氨酸，以及含有这种新型氨基酸的多肽，如神经降压素类似物。 此外，本发明提供新色氨酸衍生物，5-羟色胺样新色氨酸衍生物和含有这些衍生物的多肽。 本发明还提供了制备新色氨酸，新色氨酸衍生物，血清素样新色氨酸衍生物和含有这些化合物的组合物的方法。 此外，本发明提供了在哺乳动物中诱导神经降压素反应的方法以及用于治疗具有5-羟色胺识别分子的哺乳动物的方法。