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    Drug delivery device with in-plane bandpass regulation check valve in heat-shrink packaging
    1.
    发明授权
    Drug delivery device with in-plane bandpass regulation check valve in heat-shrink packaging 有权
    药物输送装置，带有热收缩包装内的带内调节止回阀

    公开(公告)号：US08372046B2

    公开(公告)日：2013-02-12

    申请号：US12709188

    申请日：2010-02-19

    申请人： Ellis Meng ,  Ronalee Lo Mann

    发明人： Ellis Meng ,  Ronalee Lo Mann

    IPC分类号： A61M5/00

    CPC分类号： A61M5/00 ,  A61F9/0017 ,  A61M5/14276 ,  A61M5/16881 ,  A61M2039/2413 ,  A61M2039/242 ,  A61M2210/0612

    摘要： A drug delivery device may include a drug reservoir configured to contain and controllably deliver a fluidic drug. A tube may be configured to deliver the fluid from the drug reservoir through a lumen in the tube to another location. A valve wholly within the lumen of the tube may regulate the flow of the fluid through the tube without substantially diverting the direction in which the fluid flows through the tube. The valve may contain only a single member which moves during operation of the valve. The valve may be configured to regulate the flow of fluid in a bandpass manner by allowing fluid to flow through the valve only when the pressure of the fluid is above a minimum and below a maximum. The valve may be held in place within the tube solely by frictional force between the valve and a wall of the tube.

    摘要翻译： 药物递送装置可以包括被配置为容纳和可控地递送流体药物的药物储存器。 管可以被配置成将来自药物储存器的流体通过管中的管腔输送到另一位置。 完全在管腔中的阀可以调节流体通过管的流动，而不会使流体流过管的方向基本上转向。 阀可以仅包含在阀操作期间移动的单个构件。 阀可以被配置为通过仅当流体的压力高于最小值并且低于最大值时允许流体流过阀门才能以带通方式调节流体的流动。 阀可以仅通过阀和管壁之间的摩擦力保持在管内的适当位置。

    DRUG DELIVERY DEVICE WITH IN-PLANE BANDPASS REGULATION CHECK VALVE IN HEAT-SHRINK PACKAGING
    2.
    发明申请
    DRUG DELIVERY DEVICE WITH IN-PLANE BANDPASS REGULATION CHECK VALVE IN HEAT-SHRINK PACKAGING 有权
    具有平面内压力调节装置的药物输送装置在热收缩包装中检查阀

    公开(公告)号：US20100217209A1

    公开(公告)日：2010-08-26

    申请号：US12709188

    申请日：2010-02-19

    申请人： Ellis Meng ,  Ronalee Lo Mann

    发明人： Ellis Meng ,  Ronalee Lo Mann

    IPC分类号： A61M5/00

    CPC分类号： A61M5/00 ,  A61F9/0017 ,  A61M5/14276 ,  A61M5/16881 ,  A61M2039/2413 ,  A61M2039/242 ,  A61M2210/0612

    摘要： A drug delivery device may include a drug reservoir configured to contain and controllably deliver a fluidic drug. A tube may be configured to deliver the fluid from the drug reservoir through a lumen in the tube to another location. A valve wholly within the lumen of the tube may regulates the flow of the fluid through the tube without substantially diverting the direction in which the fluid flows through the tube. The valve may contain only a single member which moves during operation of the valve. The valve may be configured to regulate the flow of fluid in a bandpass manner by allowing fluid to flow through the valve only when the pressure of the fluid is above a minimum and below a maximum. The valve may be held in place within the tube solely by frictional force between the valve and a wall of the tube.

    摘要翻译： 药物递送装置可以包括被配置为容纳和可控地递送流体药物的药物储存器。 管可以被配置成将来自药物储存器的流体通过管中的管腔输送到另一位置。 完全在管腔中的阀可以调节流体通过管的流动，而不会使流体流过管的方向基本上转向。 阀可以仅包含在阀操作期间移动的单个构件。 阀可以被配置为通过仅当流体的压力高于最小值并且低于最大值时允许流体流过阀门才能以带通方式调节流体的流动。 阀可以仅通过阀和管壁之间的摩擦力保持在管内的适当位置。

    Interconnect for MEMS device including a viscoelastic septum
    5.
    发明授权
    Interconnect for MEMS device including a viscoelastic septum 失效
    用于MEMS器件的互连，包括粘弹性隔膜

    公开(公告)号：US08518481B2

    公开(公告)日：2013-08-27

    申请号：US13251959

    申请日：2011-10-03

    申请人： Ellis Meng ,  Ronalee Lo

    发明人： Ellis Meng ,  Ronalee Lo

    IPC分类号： B05D7/00

    CPC分类号： B01L3/502715 ,  B01L2200/027 ,  B01L2300/044 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2400/046 ,  G01N35/1079

    摘要： Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.

    摘要翻译： 提供了一种用于细长结构的微机电系统（MEMS）装置。 MEMS器件包括大致平面的衬底，形成在衬底上的器件壁层，形成在器件壁层中的隔膜腔，形成在与隔膜腔流体连通的器件壁层中的通道和设置在隔膜腔中的隔膜元件 隔膜腔。 隔膜元件由粘弹性材料形成。 隔膜元件限定隔膜入口表面和隔膜出口表面，其中隔膜出口表面暴露于通道并且设置在隔膜入口表面和通道之间。 隔膜元件没有通过在隔膜入口和出口表面之间延伸的隔膜元件形成的任何开口。 还提供了与MEMS器件的制造和相互作用的方法。

    MEMS ELECTROCHEMICAL BELLOWS ACTUATOR
    6.
    发明申请
    MEMS ELECTROCHEMICAL BELLOWS ACTUATOR 有权
    MEMS电化学发光二极管激光器

    公开(公告)号：US20100222769A1

    公开(公告)日：2010-09-02

    申请号：US12709335

    申请日：2010-02-19

    申请人： Ellis Meng ,  Po-Ying Li ,  Tuan Hoang

    发明人： Ellis Meng ,  Po-Ying Li ,  Tuan Hoang

    IPC分类号： A61M5/142

    CPC分类号： A61M5/14276 ,  A61M2210/0612

    摘要： An implantable fluid delivery system may include a fluid reservoir configured to hold a supply of fluid, to dispense that fluid under the control of an actuator, and to be implanted within the body of a living host. An actuator within the fluid reservoir may cause the fluid to be controllably dispensed from the fluid reservoir. The actuator may include a bellows configured to expand in a direction when inflated. The bellows may have folds with surfaces which run substantially perpendicular to the direction of expansion in a collapsed state and which define a stacked set of convolutions. Each convolution may have a collapsed height of no more than 1 mm and a width perpendicular to the direction of expansion of no more than 8 mm. Electrodes may be configured to come in electrical contact with an electrolyte within the bellows and to cause electricity to run through the electrolyte, thereby causing the electrolyte to break down into a gas and, in turn, to cause the bellows to expand. Methods of making the bellows which utilize stacked sheets are also disclosed.

    摘要翻译： 可植入流体输送系统可以包括被配置为保持流体供应的流体储存器，以在致动器的控制下分配该流体并且植入到活体的体内。 流体储存器内的致动器可以使流体从流体储存器被可控地分配。 致动器可以包括构造成在膨胀的方向上膨胀的波纹管。 波纹管可以具有折叠，其表面在折叠状态下基本上垂直于膨胀方向延伸，并且限定了一组堆叠的卷积。 每个卷积可以具有不大于1mm的折叠高度和垂直于不大于8mm的膨胀方向的宽度。 电极可以被配置为与波纹管​​内的电解质电接触并导致电流穿过电解质，从而导致电解质分解成气体，从而导致波纹管膨胀。 还公开了制造利用堆叠片材的波纹管的方法。

    Tracking and controlling fluid delivery from chamber
    8.
    发明授权
    Tracking and controlling fluid delivery from chamber 有权
    跟踪和控制从腔室输送液体

    公开(公告)号：US09222819B2

    公开(公告)日：2015-12-29

    申请号：US13487000

    申请日：2012-06-01

    申请人： Christian A. Gutierrez ,  Ellis Meng

    发明人： Christian A. Gutierrez ,  Ellis Meng

    IPC分类号： G01F3/22 ,  B67D1/04 ,  B67D1/08 ,  G01F3/20 ,  G01F11/08 ,  G01M3/16 ,  G01M3/40

    CPC分类号： G01F3/227 ,  B67D1/0437 ,  B67D1/0855 ,  G01F3/20 ,  G01F11/086 ,  G01M3/16 ,  G01M3/40

    摘要： Electrochemical impedance may be used for accurate and real-time tracking and control of fluid delivery from fluid-filled chambers, such as from drug delivery devices. At least two measurement electrodes may be placed within the chamber in contact with the fluid to be sensed. Application of a small alternating current using these electrodes through the fluid/drug may allow measurement of electrochemical impedance. Volumetric changes of the compressible chamber due to movement of at least one surface within the compressible chamber (such as an actuating bellows or flexible diaphragm), may induce changes in the measured electrochemical impedance. Measuring these changes may allow for tracking of ejected liquid volumes from the compressible chamber. By taking the time-derivative of this signal, the rate of volume change can be tracked and therefore the rate of ejected fluid (flow rate) can be deduced.

    摘要翻译： 电化学阻抗可用于精确和实时跟踪和控制从填充液体的腔室（例如来自药物输送装置）的流体输送。 至少两个测量电极可以放置在室内与要感测的流体接触。 使用这些电极通过流体/药物施加小的交流电流可以测量电化学阻抗。 由于可压缩室内的至少一个表面的移动（例如致动波纹管或柔性隔膜），可压缩室的体积变化可能引起测量的电化学阻抗的变化。 测量这些变化可以允许跟踪来自可压缩室的喷射液体体积。 通过采用该信号的时间导数，可以跟踪体积变化率，因此可以推导出喷射流体的速率（流量）。

    Microelectromechanical (MEMS) pressure transducer
    9.
    发明授权
    Microelectromechanical (MEMS) pressure transducer 有权
    微机电（MEMS）压力传感器

    公开(公告)号：US08490497B2

    公开(公告)日：2013-07-23

    申请号：US13052958

    申请日：2011-03-21

    申请人： Christian A. Gutierrez ,  Ellis Meng

    发明人： Christian A. Gutierrez ,  Ellis Meng

    IPC分类号： G01L9/00 ,  H01S4/00

    CPC分类号： G01L11/00 ,  G01L11/02 ,  G01L11/04 ,  Y10T29/49002

    摘要： A pressure transducer for measuring pressure may include an all-polymer chamber that has no dimension greater than 1 mm. There may be fluid within the chamber, a gaseous bubble trapped within the fluid, and electrodes in contact with the fluid. The electrodes may enable a measurement of changes in the impedance of the fluid caused by changes in the volume of the gaseous bubble caused by changes in the pressure to be measured.The pressure transducer may be made by depositing the chamber, placing the fluid within the chamber, and generating the gaseous bubble within the fluid with electrolysis.

    摘要翻译： 用于测量压力的压力传感器可以包括没有尺寸大于1mm的全聚合物室。 室内可能存在流体，被捕获在流体内的气泡和与流体接触的电极。 电极可以测量由待测量的压力变化引起的气泡体积变化引起的流体阻抗的变化。 压力传感器可以通过沉积室，将流体放置在室内，并通过电解产生流体内的气泡来制造。

    INTERCONNECT FOR MEMS DEVICE INCLUDING A VISCOELASTIC SEPTUM
    10.
    发明申请
    INTERCONNECT FOR MEMS DEVICE INCLUDING A VISCOELASTIC SEPTUM 失效
    用于包括粘弹性体的MEMS器件的互连

    公开(公告)号：US20120017423A1

    公开(公告)日：2012-01-26

    申请号：US13251959

    申请日：2011-10-03

    申请人： Ellis Meng ,  Ronalee Lo

    发明人： Ellis Meng ,  Ronalee Lo

    IPC分类号： H01S4/00

    CPC分类号： B01L3/502715 ,  B01L2200/027 ,  B01L2300/044 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2400/046 ,  G01N35/1079

    摘要： Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.

    摘要翻译： 提供了一种用于细长结构的微机电系统（MEMS）装置。 MEMS器件包括大致平面的衬底，形成在衬底上的器件壁层，形成在器件壁层中的隔膜腔，形成在与隔膜腔流体连通的器件壁层中的通道和设置在隔膜腔中的隔膜元件 隔膜腔。 隔膜元件由粘弹性材料形成。 隔膜元件限定隔膜入口表面和隔膜出口表面，其中隔膜出口表面暴露于通道并且设置在隔膜入口表面和通道之间。 隔膜元件没有通过在隔膜入口和出口表面之间延伸的隔膜元件形成的任何开口。 还提供了与MEMS器件的制造和相互作用的方法。