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公开(公告)号:US20240033939A1
公开(公告)日:2024-02-01
申请号:US18282587
申请日:2022-11-14
申请人: Run Ze GAO , Carolyn L. REN , Clark R. DICKERSON , Jacqueline Mary KORMYLO , Peter S. LEE , Vivian Ngoc Tram MAI
发明人: Run Ze GAO , Carolyn L. REN , Clark R. DICKERSON , Jacqueline Mary KORMYLO , Peter S. LEE , Vivian Ngoc Tram MAI
CPC分类号: B25J9/20 , F15C3/04 , F15C5/00 , F16K99/0015 , F16K99/0055 , F16K2099/008
摘要: A device for use with soft robotic devices comprises soft fluidic actuators, a microfluidic/minifluidic valves and channels module, a fluidic module, sensors, and a control module. The actuators are operable to apply predetermined effects to surfaces and/or objects. The microfluidic/minifluidic valves and channels module has micro/mini fluidic channels and on-chip fluidic pressure-controlled pinch valves forming a fluidic network. Each pinch valve has a valve pinch chamber, a membrane layer, and a valve control pressure chamber. The control module receives signals from the sensors and controls the fluidic module to control the pinch valves to induce flow of fluid under pressure to the actuators. An active compression apparel may include the device, and may have a skin contact backing layer and a strain-limiting backing layer sandwiching the actuators which are operable to provide compression to the skin and/or limb of a user through the at least one backing layer.
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公开(公告)号:US20180043359A1
公开(公告)日:2018-02-15
申请号:US15670645
申请日:2017-08-07
发明人: Yi-Cheng LIN , Sung-Yi YANG
IPC分类号: B01L3/00
CPC分类号: B01L3/502707 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , F16K99/00 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/008
摘要: A method of manufacturing a microfluidic chip includes providing an upper mold having multiple upper ribs extending along a second direction, and a lower mold having multiple lower ribs extending along a first direction different from the second direction, forming a forming material in a filling space defined by the upper and lower molds to provide a channeled plate having multiple upper microfluidic channels complementary in shape to the upper ribs, lower microfluidic channels complementary in shape to the lower ribs, and multiple thin film valves formed at intersections where the upper microfluidic channels intersect the lower microfluidic channels, separating the upper and lower molds, and covering the lower and upper microfluidic channels.
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公开(公告)号:US09879669B2
公开(公告)日:2018-01-30
申请号:US14948528
申请日:2015-11-23
CPC分类号: F04B53/1085 , A61B5/022 , A61B5/0235 , F04B53/106 , F04B53/1062 , F16K7/12 , F16K7/17 , F16K15/144 , F16K27/0236 , F16K99/0015 , F16K2099/0073 , F16K2099/008 , F16K2099/0086
摘要: A fluid control apparatus includes a piezoelectric pump and valve. The valve includes a second valve housing, second seal member, diaphragm, first seal member, and first valve housing and has a structure in which they are laminated in sequence. The first valve housing includes a second vent and third vent, has a valve seat, and includes six cavities. The second valve housing has a first vent and first vent and includes a valve seat and six first protrusions. The second valve housing further includes six second protrusions nearer the outer edges than the six first protrusions, as seen in the x-axis direction in plan view.
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公开(公告)号:US09815057B2
公开(公告)日:2017-11-14
申请号:US14263208
申请日:2014-04-28
申请人: HANDYLAB, INC.
发明人: Kalyan Handique
CPC分类号: B01L3/502738 , B01L3/5025 , B01L3/502707 , B01L3/502723 , B01L7/52 , B01L2200/0684 , B01L2200/142 , B01L2300/0803 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/14 , B01L2300/1827 , B01L2300/1844 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0694 , C12Q1/6806 , C12Q1/686 , F16K99/0001 , F16K2099/008 , F16K2099/0084
摘要: The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve.
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公开(公告)号:US09791068B2
公开(公告)日:2017-10-17
申请号:US14155183
申请日:2014-01-14
发明人: Richard A. Mathies , Jungkyu Kim , Erik C. Jensen
CPC分类号: F16K99/0015 , F04B19/006 , F16K99/0005 , F16K99/0059 , F16K2099/008 , F16K2099/0094
摘要: The present disclosure relates to method, system for microfluidic control. One or more embodiments of the disclosure relate to pneumatically actuated “lifting gate” microvalves and pumps. In some embodiments, a microfluidic control module is provided, which comprises a plurality of pneumatic channels and a plurality of lifting gate valves configured to be detachably affixed to a substrate. The plurality of lifting gate valves are aligned with at least one fluidic channel on the substrate when affixed to the substrate. Each of the valves comprises: a pneumatic layer, a fluidic layer, and a pneumatic displacement chamber between the pneumatic layer and the fluidic layer. The fluidic layer has a first side facing the pneumatic layer and a second side facing away from the pneumatic layer, wherein the second side has a protruding gate configured to obstruct a flow of the fluidic channel when the fluidic layer is at a resting state.
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公开(公告)号:US20170282183A1
公开(公告)日:2017-10-05
申请号:US15474572
申请日:2017-03-30
申请人: Enplas Corporation
发明人: Koichi ONO
CPC分类号: B01L3/502784 , B01L3/502707 , B01L3/502715 , B01L2200/027 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , F16K99/0015 , F16K99/0028 , F16K99/0042 , F16K2099/008 , F16K2099/0084
摘要: A fluid handling device includes: a substrate including a first surface and a second surface which are opposite to each other, wherein a first recess which allows fluid to flow therethrough is formed on the first surface; a film including a third surface and a fourth surface which are opposite to each other, wherein at least a pair of second recesses is formed on the third surface; and at least a pair of electrodes whose shape is defined by the second recesses, the electrodes being disposed in the second recesses and configured to apply an electric field to an inside of the first recess, the film being joined to the substrate such that the first surface and the fourth surface face each other.
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公开(公告)号:US09693894B2
公开(公告)日:2017-07-04
申请号:US14295102
申请日:2014-06-03
申请人: Yu-Chong Tai , Mark Humayun , Jason Shih
发明人: Yu-Chong Tai , Mark Humayun , Jason Shih
IPC分类号: A61F7/12 , A61F9/00 , A61K9/00 , A61M5/142 , A61M5/168 , A61M37/00 , B81C1/00 , F04B43/04 , F16K99/00 , A61M5/145 , A61M5/155
CPC分类号: A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要: Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.
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公开(公告)号:US20170184221A1
公开(公告)日:2017-06-29
申请号:US15388332
申请日:2016-12-22
CPC分类号: F16K99/0042 , F16K99/0015 , F16K2099/008 , F16K2099/0082 , G08B6/00
摘要: A strained bilayer film with reinforcing members is used to open and close gas flow outlets in a microvalve array. The bottom layer of the bilayer film is compressive and the top layer is tensile. Reinforcing members are made from compressive material that accomplishes the dual objectives of reducing potential defects at the interface between the anchor region and the free region of the actuator, and controlling the stresses along the edges of the strained bilayer to avoid curling as the actuator unrolls from its normal coiled configuration in response to an applied voltage. Because of the configuration, the strained bilayer film occupies a minimal amount of space compared to other systems when the valve is opened, and it permits a higher density of microvalves to be utilized. Optional supports are provided over gas flow channel openings to increase the area over which the voltage is applied, increasing electrostatic stability of the actuators in maintaining their unrolled state for a variety of uses. Such uses include, but are not limited to, pneumatic manifolds or other practical uses that involve transmission of air or fluids, including for lab-on-a-chip applications, as well as for providing air flow channels for a configurable tactile tablet to provide the visually impaired with a tactile representation of shapes and designs, to name some examples.
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公开(公告)号:US09630177B2
公开(公告)日:2017-04-25
申请号:US14656028
申请日:2015-03-12
申请人: GENAPSYS, INC.
发明人: Seth Stern , Hesaam Esfandyarpour , David Eberhart
IPC分类号: B01L3/00 , F16K3/00 , A61J1/06 , G01N21/00 , B01L99/00 , C12N15/10 , B01L7/00 , B01F5/02 , B01F13/00 , B01F3/08 , F16K99/00
CPC分类号: B01L3/502738 , B01F3/0865 , B01F5/0206 , B01F13/0059 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L7/525 , B01L2200/0668 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/18 , B01L2300/1822 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , C12N15/1013 , C12Q1/6806 , C12Q1/6869 , F16K99/0015 , F16K99/0059 , F16K2099/008 , F16K2099/0084
摘要: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.
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公开(公告)号:US09328850B2
公开(公告)日:2016-05-03
申请号:US14313147
申请日:2014-06-24
IPC分类号: F16K99/00
CPC分类号: F16K99/0021 , F16K99/0011 , F16K99/0044 , F16K99/0055 , F16K2099/008 , Y10T137/2213 , Y10T137/2224 , Y10T137/3084
摘要: A microvalve includes a base plate having a surface defining an actuator cavity. A venting groove extends from a first cavity portion of the actuator cavity having a dead end region to a second cavity portion of the actuator cavity having a structure that can vent air from the microvalve. A cover plate includes a surface having an actuator cavity provided therein that includes a first cavity portion having a dead end region and a second cavity portion having a structure that can vent air from the microvalve. An intermediate plate includes a displaceable member that is disposed within the actuator cavity for movement between a closed position, wherein the displaceable member prevents fluid communication through the microvalve, and an opened position, wherein the displaceable member does not prevent fluid communication through the microvalve.
摘要翻译: 微型阀包括具有限定致动器腔的表面的基板。 排气槽从具有死端区域的致动器空腔的第一空腔部分延伸到致动器空腔的第二空腔部分,其具有能够从微型阀排出空气的结构。 盖板包括具有设置在其中的致动器腔的表面,其包括具有死端区域的第一空腔部分和具有能够从微型阀排出空气的结构的第二空腔部分。 中间板包括设置在致动器腔内的可移动构件,用于在关闭位置之间移动,其中可移位构件防止通过微型阀的流体连通和打开位置,其中可移位构件不阻止流体通过微型阀连通。
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