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公开(公告)号：US08748581B2
公开(公告)日：2014-06-10
申请号：US13263179
申请日：2010-04-12
申请人： Els Anna Alice Beirnaert , Cedric Jozef Neotere Ververken , Joost Alexander Kolkman , Maarten Van Roy
发明人： Els Anna Alice Beirnaert , Cedric Jozef Neotere Ververken , Joost Alexander Kolkman , Maarten Van Roy
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/4283 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/565 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
摘要： The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that have an improved efficacy and/or potency, and which are capable of (partially, or preferably totally) blocking the IL-6/IL-6R interaction and/or inhibit signalization through IL-6, IL-6R and/or the IL-6/IL-6R complex. The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells, and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及与改善的亲和力和/或亲合力有关的和/或可特异性结合白细胞介素-6受体（IL-6R）的氨基酸序列和/或具有改善的功效和/或效力的氨基酸序列，和 其能够（部分或优选全部）阻断IL-6 / IL-6R相互作用和/或通过IL-6，IL-6R和/或IL-6 / IL-6R复合物抑制信号传导。 本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 本发明还涉及编码这种氨基酸序列和多肽的核酸，制备此类氨基酸序列和多肽的方法，将表达或能够表达该氨基酸序列或多肽的细胞宿主给组合物，特别是药物组合物 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞，以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。
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2.发明申请AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS 有权指导针对IL-6R和包含IL-6R相关疾病和疾病的多肽的氨基酸序列公开(公告)号：US20120077731A1
公开(公告)日：2012-03-29
申请号：US13263179
申请日：2010-04-12
申请人： Els Anna Alice Beirnaert , Cedric Jozef Neotere Ververken , Joost Alexander Kolkman , Maarten Van Roy
发明人： Els Anna Alice Beirnaert , Cedric Jozef Neotere Ververken , Joost Alexander Kolkman , Maarten Van Roy
IPC分类号： A61K38/08 , C07K7/08 , C07K19/00 , C07K14/54 , C12N15/12 , A61P37/00 , A61P35/00 , A61P19/00 , A61P19/10 , A61P3/00 , A61P17/06 , A61P29/00 , A61K38/10 , C12P21/02 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C07K7/06
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07K16/18 , C07K16/4283 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/565 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/09
摘要： The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that have an improved efficacy and/or potency, and which are capable of (partially, or preferably totally) blocking the IL-6/IL-6R interaction and/or inhibit signalization through IL-6, 1L-6R and/or the IL-6/IL-6R complex. The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells, and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
摘要翻译： 本发明涉及与改善的亲和力和/或亲合力有关的和/或可特异性结合白细胞介素-6受体（IL-6R）的氨基酸序列和/或具有改善的功效和/或效力的氨基酸序列，和 其能够（部分或优选完全）阻断IL-6 / IL-6R相互作用和/或通过IL-6,1L-6R和/或IL-6 / IL-6R复合物抑制信号传导。 本发明还涉及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 本发明还涉及编码这种氨基酸序列和多肽的核酸，制备此类氨基酸序列和多肽的方法，将表达或能够表达该氨基酸序列或多肽的细胞宿主给组合物，特别是药物组合物 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞，以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。
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公开(公告)号：US09573992B2
公开(公告)日：2017-02-21
申请号：US14128719
申请日：2012-06-14
CPC分类号： C07K16/18 , C07K16/2863 , C07K16/32 , C07K2317/14 , C07K2317/22 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to amino acid sequences that are capable of binding to serum albumin; to proteins and polypeptides comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, proteins or polypeptides; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, proteins and polypeptides; and to uses of such amino acid sequences, proteins and polypeptides.
摘要翻译： 本发明涉及能够结合血清白蛋白的氨基酸序列; 包括或基本上由这样的氨基酸序列组成的蛋白质和多肽; 涉及编码这种氨基酸序列，蛋白质或多肽的核酸; 包括这样的氨基酸序列，蛋白质和多肽的组合物，特别是药物组合物; 以及这些氨基酸序列，蛋白质和多肽的使用。
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公开(公告)号：US20180009888A9
公开(公告)日：2018-01-11
申请号：US14128681
申请日：2012-06-25
申请人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
CPC分类号： C07K16/28 , C07K16/00 , C07K16/4283 , C07K2317/22 , C07K2317/569 , C07K2317/94 , C07K2319/30 , G01N33/6854
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; —methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; —modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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公开(公告)号：US08703135B2
公开(公告)日：2014-04-22
申请号：US13435567
申请日：2012-03-30
申请人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
发明人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6876 , G01N33/53
摘要： The present invention relates to biological materials related to c-Met possibly in combination with VEGF and/or EGFR, and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. Methods and kits for assessing the responsiveness of a patient to c-Met therapy are also described and provided.
摘要翻译： 本发明涉及与可能与VEGF和/或EGFR组合的c-Met相关的生物学材料，更具体地涉及编码这些多肽的多肽，核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 还描述和提供了用于评估患者对c-Met治疗的反应性的方法和试剂盒。
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公开(公告)号：US20120244164A1
公开(公告)日：2012-09-27
申请号：US13435567
申请日：2012-03-30
申请人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
发明人： Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Cedric Jozef Neotere Ververken , Tinneke Denayer
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6876 , G01N33/53
摘要： The present invention relates to biological materials related to c-Met possibly in combination with VEGF and/or EGFR, and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. Methods and kits for assessing the responsiveness of a patient to c-Met therapy are also described and provided.
摘要翻译： 本发明涉及与可能与VEGF和/或EGFR组合的c-Met相关的生物学材料，更具体地涉及编码这些多肽的多肽，核酸; 制备这种多肽的方法; 以宿主表达或能够表达这种多肽的细胞; 组合物，特别是涉及用于预防，治疗或诊断目的的包含这种多肽的药物组合物。 还描述和提供了用于评估患者对c-Met治疗的反应性的方法和试剂盒。
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