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公开(公告)号：US20070237778A1
公开(公告)日：2007-10-11
申请号：US11691824
申请日：2007-03-27
申请人： Emily Shen , Frederick Bex , Yogendra Kharode , Vargheese Chennathukuzhi , Murty Chengalvala , Ashok Bapat , Panayiotis Stevis , Gregory Kopf
发明人： Emily Shen , Frederick Bex , Yogendra Kharode , Vargheese Chennathukuzhi , Murty Chengalvala , Ashok Bapat , Panayiotis Stevis , Gregory Kopf
IPC分类号： A61K48/00 , A61K39/395 , A61K38/17
CPC分类号： A61K31/663 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A61K31/675 , A61K38/00 , A61K38/179 , A61K45/06 , C07K14/4753 , C07K14/51 , C07K16/22 , C12Q1/6883 , C12Q2600/158 , G01N33/74 , G01N2333/475 , G01N2333/51 , G01N2800/10 , G01N2800/108 , A61K2300/00
摘要： The invention provides methods for treating or preventing bone degenerative disorders. The disorders treated or prevented include, for example, osteopenia, osteomalacia, osteoporosis, osteomyeloma, osteodystrophy, Paget's disease, osteogenesis imperfecta, and bone degenerative disorders associated with chronic renal disease, hyperparathyroidism, and long-term use of corticosteroids. The disclosed therapeutic methods include administering to a mammal an inhibitor of GDF-9 or BMP-15 in an amount effective to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) stimulate new bone formation; and/or (5) maintain bone mass and/or bone quality. The invention also provides methods for administering a GDF-9 agonist or a BMP-15 agonist to treat a bone disorder characterized by increased bone density or mass.
摘要翻译： 本发明提供治疗或预防骨退行性疾病的方法。 所治疗或预防的疾病包括例如骨质减少症，骨软化症，骨质疏松症，骨髓瘤，骨营养不良，佩吉特氏病，成骨不全症以及与慢性肾脏病，甲状旁腺功能亢进和长期使用皮质类固醇相关的骨退行性疾病。 所公开的治疗方法包括给予哺乳动物GDF-9或BMP-15的抑制剂，其量有效：（1）治疗或预防骨退行性疾病; （2）慢骨退化; （3）恢复失骨; （4）刺激新骨形成; 和/或（5）维持骨量和/或骨质量。 本发明还提供了用于施用GDF-9激动剂或BMP-15激动剂以治疗以增加的骨密度或质量为特征的骨病症的方法。
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公开(公告)号：US20070105188A1
公开(公告)日：2007-05-10
申请号：US11591061
申请日：2006-11-01
申请人： Alexander Travis , Gregory Kopf
发明人： Alexander Travis , Gregory Kopf
CPC分类号： G01N33/5005 , A01N1/02 , G01N33/5044 , Y10S530/827 , Y10S530/85 , Y10S530/852
摘要： This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm to respond to capacitation and/or acrosomal exocytosis stimuli. The method comprises determination of distribution pattern for GM1. The method can be used for both diagnostic and predictive purposes when assessing male reproductive fitness, and can also be used to assess the effects on sperm of cryoprotective agents and protocols, and contraceptive agents.
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公开(公告)号：US20050037334A1
公开(公告)日：2005-02-17
申请号：US10898041
申请日：2004-07-23
申请人： Alexander Travis , Gregory Kopf
发明人： Alexander Travis , Gregory Kopf
IPC分类号： A01N1/02 , A61B20060101 , A61K49/00 , C07K2/00 , C12N5/00 , C12N5/06 , C12Q1/00 , G01N33/50 , G01N33/567
CPC分类号： G01N33/5005 , A01N1/02 , G01N33/5044 , Y10S530/827 , Y10S530/85 , Y10S530/852
摘要： This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm to respond to capacitation and/or acrosomal exocytosis stimuli. The method comprises determination of distribution pattern for GM1. The method can be used for both diagnostic and predictive purposes when assessing male reproductive fitness, and can also be used to assess the effects on sperm of cryoprotective agents and protocols, and contraceptive agents.
摘要翻译： 本发明描述了非能力精子中神经节苷脂GM1的独特分布模式，并且证明GM1的分布模式发生可能与获能过程和/或与顶体胞吐作用相关的变化。 因此，本发明公开了一种确定精子对能力和/或顶体胞吐刺激作用的能力的方法。 该方法包括确定GM1的分布模式。 当评估男性生殖适应性时，该方法可用于诊断和预测目的，并且还可用于评估对冷冻保护剂和方案对精子和对避孕药物的影响。
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