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公开(公告)号：US10857119B2
公开(公告)日：2020-12-08
申请号：US16045617
申请日：2018-07-25
发明人： Jae Wha Kim , Sei-Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Jae Min Shin , Young Eun Ko , Tae Suk Lee , Myung Hwan Kim , Jong Koo Kang , Yong-Hae Han , Ki-Young Sohn
IPC分类号： A61K31/231 , A61K31/23 , A23L33/10 , A61K35/32 , A61K31/22
摘要： The present invention relates to a composition containing a monoacetyldiglyceride compound as an active ingredient, for inhibiting blood cancer or metastasis, and a use thereof. The monoacetyldiglyceride compound according to the present invention has excellent effects of inhibiting the expression of IL-4 and inhibiting the activity of STAT-6, and thereby is capable of overcoming side effects of currently used blood cancer or metastasis inhibiting agents. Also, the monoacetyldiglyceride compound is a non-toxic compound having superior therapeutic effects and thus can be useful as a composition for preventing, treating, or improving blood cancer and metastasis.
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2.发明申请公开(公告)号：US20200330421A1
公开(公告)日：2020-10-22
申请号：US16886280
申请日：2020-05-28
发明人： Jae Wha Kim , Sei-Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Jae Min Shin , Young Eun Ko , Tae Suk Lee , Myung Hwan Kim , Jong Koo Kang , Yong-Hae Han , Ki Young Sohn
IPC分类号： A61K31/231 , A23L33/10 , A61K35/32 , A61K31/23
摘要： The present invention relates to a composition containing a monoacetyldiglyceride compound as an active ingredient, for inhibiting blood cancer or metastasis, and a use thereof. The monoacetyldiglyceride compound according to the present invention has excellent effects of inhibiting the expression of IL-4 and inhibiting the activity of STAT-6, and thereby is capable of overcoming side effects of currently used blood cancer or metastasis inhibiting agents. Also, the monoacetyldiglyceride compound is a non-toxic compound having superior therapeutic effects and thus can be useful as a composition for preventing, treating, or improving blood cancer and metastasis.
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3.发明申请COMPOSITION CONTAINING MONOACETYLDIACYLGLYCEROL COMPOUND AS ACTIVE INGREDIENT FOR INHIBITING BLOOD CANCER OR METASTASIS 审中-公开含有单一乙酰胆碱酯化合物的组合物作为抑制血液癌或METASTASIS的主动成分公开(公告)号：US20160256428A1
公开(公告)日：2016-09-08
申请号：US14912916
申请日：2014-08-18
发明人： Jae Wha Kim , Sei Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Jae Min Shin , Young Eun Ko , Tae Suk Lee , Myung Hwan Kim , Jong Koo Kang , Yong-Hae Han , Ki-Young Sohn
IPC分类号： A61K31/231 , A61K35/32
CPC分类号： A61K31/231 , A23L33/10 , A23V2002/00 , A61K31/22 , A61K31/23 , A61K35/32
摘要： The present invention relates to a composition containing a monoacetyldiglyceride compound as an active ingredient, for inhibiting blood cancer or metastasis, and a use thereof. The monoacetyldiglyceride compound according to the present invention has excellent effects of inhibiting the expression of IL-4 and inhibiting the activity of STAT-6, and thereby is capable of overcoming side effects of currently used blood cancer or metastasis inhibiting agents. Also, the monoacetyldiglyceride compound is a non-toxic compound having superior therapeutic effects and thus can be useful as a composition for preventing, treating, or improving blood cancer and metastasis.
摘要翻译： 本发明涉及含有单乙酰甘油二酯化合物作为活性成分的抑制血癌或转移的组合物及其用途。 根据本发明的单乙酰甘油二酯化合物具有抑制IL-4表达和抑制STAT-6活性的优异效果，从而能够克服目前使用的血癌或转移抑制剂的副作用。 此外，单乙酰甘油二酯化合物是具有优异治疗效果的无毒化合物，因此可用作预防，治疗或改善血液癌和转移的组合物。
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公开(公告)号：US10058527B2
公开(公告)日：2018-08-28
申请号：US14912916
申请日：2014-08-18
发明人： Jae Wha Kim , Sei Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Jae Min Shin , Young Eun Ko , Tae Suk Lee , Myung Hwan Kim , Jong Koo Kang , Yong-Hae Han , Ki-Young Sohn
IPC分类号： A61K31/225 , A61K31/231 , A61K31/23 , A61K35/32 , A23L33/10 , A61K31/22
CPC分类号： A61K31/231 , A23L33/10 , A23V2002/00 , A61K31/22 , A61K31/23 , A61K35/32
摘要： The present invention relates to a composition containing a monoacetyldiglyceride compound as an active ingredient, for inhibiting blood cancer or metastasis, and a use thereof. The monoacetyldiglyceride compound according to the present invention has excellent effects of inhibiting the expression of IL-4 and inhibiting the activity of STAT-6, and thereby is capable of overcoming side effects of currently used blood cancer or metastasis inhibiting agents. Also, the monoacetyldiglyceride compound is a non-toxic compound having superior therapeutic effects and thus can be useful as a composition for preventing, treating, or improving blood cancer and metastasis.
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公开(公告)号：US09763908B2
公开(公告)日：2017-09-19
申请号：US14915799
申请日：2014-09-03
发明人： Jae Wha Kim , Sei-Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Jae Mine Yoo , Tae-Suk Lee , JongKoo Kang , Hye Kyung Kim , Jin Soo Yook , Yong-Hae Han , Ki Young Sohn
CPC分类号： A61K31/231 , A23L33/10 , A23V2002/00 , A61K8/37 , A61K9/0014 , A61K9/08 , A61K47/44 , A61K2800/10 , A61Q19/00
摘要： The present invention relates to a pharmaceutical composition, functional health food composition, quasi-drug composition, and cosmetic composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing, treating or improving atopic dermatitis. The monoacetyldiacylglycerol compound of the present invention has an excellent effect of suppression of IL-4 and IgE secretion, thereby overcoming side effects of an atopic dermatitis treatment agent currently in use, having no toxicity, and exhibiting an excellent treatment effect, and thus can be useful as a composition for preventing, treating, and ameliorating atopic dermatitis.
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6.发明申请COMPOSITION FOR PROMOTING DIFFERENTIATION OR PROLIFERATION OF ERYTHROCYTIC CELLS, CONTAINING MONOACETYL DIACYLGLYCEROL COMPOUND AS ACTIVE INGREDIENT 审中-公开用于促进含有作为活性成分的单乙酰胆碱酯化合物的红细胞的分化或增殖的组合物公开(公告)号：US20160279088A1
公开(公告)日：2016-09-29
申请号：US15022697
申请日：2014-09-17
发明人： Jae Wha Kim , Hai Young Jung , Ho Bum Kang , Sei-Ryang Oh , Kyung Seop Ahn , Tae-Suk Lee , JongKoo Kang , Myung Hwan Kim , Yong-Hae Han , Ki Young Sohn
IPC分类号： A61K31/231 , A61K9/00
CPC分类号： A61K31/231 , A23L29/03 , A23L33/115 , A61K9/0019 , A61K9/0053
摘要： The present invention relates to compositions for promoting differentiation or proliferation of erythrocytic cells containing a monoacetyl diacylglycerol compound as an active ingredient, and pharmaceutical compositions and health functional food compositions for preventing, treating or alleviating erythrocytopenia containing the same. The monoacetyldiacylglycerol compound of the present invention is effective in promoting differentiation or proliferation of erythrocytic cells. The compound can overcome the side effects of the conventional anemia treatment medicines, and has less toxicity. Thus, the compound can be effectively used for preventing, treating or alleviating oligocythemia.
摘要翻译： 本发明涉及用于促进含有单乙酰基二酰基甘油化合物作为活性成分的红细胞的分化或增殖的组合物，以及用于预防，治疗或缓解含有它们的红细胞减少症的药物组合物和保健功能食品组合物。 本发明的单乙酰基二酰基甘油化合物可有效促进红细胞分化或增殖。 该化合物可以克服常规贫血治疗药物的副作用，毒性较小。 因此，该化合物可以有效地用于预防，治疗或减轻寡细胞血症。
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公开(公告)号：US09895337B2
公开(公告)日：2018-02-20
申请号：US15048732
申请日：2016-02-19
发明人： Jae Wha Kim , Sei Ryang Oh , Kyung Seop Ahn , Ho Bum Kang , Beom Su Park , Tae Suk Lee , Jong Koo Kang , Young Sik Jung , Ki-Young Sohn
IPC分类号： A61K31/231 , A61K9/00 , A61K9/48 , A61K31/23
CPC分类号： A61K31/231 , A61K9/0053 , A61K9/4825 , A61K31/23
摘要： The invention relates to pharmaceutical compositions, as well as health functional food compositions and quasi-drug compositions, for preventing, treating, or improving rheumatoid arthritis, comprising a monoacetyldiacylglycerol compound as an active ingredient. The monoacetyldiacylglycerol of the invention is effective in inhibiting the phosphorylation of STAT-3 known to be a therapeutic target for rheumatoid arthritis. As the monoacetyldiacylglycerol is an effective therapeutic agent without toxicity, the monoacetyldiacylglycerol can overcome the side effects of the medicines currently used in the treatment of rheumatoid arthritis. Thus, the monoacetyldiacylglycerol can be used for preventing, treating or improving rheumatoid arthritis.
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