-
1.发明授权公开(公告)号：US11512303B2
公开(公告)日：2022-11-29
申请号：US16615120
申请日：2018-05-09
发明人： Haibin Chen , Yong Koy Bong , Qing Xu , Ameng Zhou , Tianran Shen , Jiadong Yang , Zhuhong Yang
摘要： The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.
-
公开(公告)号：US11274287B2
公开(公告)日：2022-03-15
申请号：US16616370
申请日：2018-05-09
发明人： Haibin Chen , Yong Koy Bong , Baoqin Cai , Qing Xu , Tianran Shen , Ameng Zhou , Jiadong Yang , Zhuhong Yang , Yaoyao Ji , Yingxin Zhang
摘要： The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.
-
搜索结果
2 条记录 (耗时 0.013 秒)
