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公开(公告)号：US20210263017A1
公开(公告)日：2021-08-26
申请号：US17195416
申请日：2021-03-08
发明人： Jacobus Johannes Maria van Dongen , José Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores-Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes van der Velden , Sebastian Böttcher , Andrew Craig Rawstron , Ruth Mary de Tute , Ludovic Bernard Simon Lhermitte , Vahid Asnafi , Ester Mejstríková , Tomasz Szczepanski , Paulo Jorge Monteiro Da Silva Lucio , Marta Martín Ayuso , Carlos Eduardo Pedreira
IPC分类号： G01N33/50 , G01N15/14 , G01N33/533 , G01N33/532
摘要： The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.
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公开(公告)号：US20180180597A1
公开(公告)日：2018-06-28
申请号：US15848719
申请日：2017-12-20
发明人： Jacobus Johannes Maria van Dongen , José Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores-Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes van der Velden , Sebastian Böttcher , Andrew Craig Rawstron , Ruth Mary de Tute , Ludovic Bernard Simon Lhermitte , Vahid Asnafi , Ester Mejstríková , Tomasz Szczepanski , Paulo Jorge Monteiro Da Silva Lucio , Marta Marin Ayuso , Carlos Eduardo Pedreira
IPC分类号： G01N33/50 , G01N33/532 , G01N33/533 , G01N15/14
CPC分类号： G01N33/5094 , G01N15/14 , G01N33/5005 , G01N33/5091 , G01N33/532 , G01N33/533 , G01N2015/1402 , G01N2015/1413
摘要： The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.
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公开(公告)号：US11442060B2
公开(公告)日：2022-09-13
申请号：US16742583
申请日：2020-01-14
IPC分类号： G01N33/50 , G01N33/569
摘要： The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.
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公开(公告)号：US10942172B2
公开(公告)日：2021-03-09
申请号：US15849233
申请日：2017-12-20
发明人： Jacobus Johannes Maria van Dongen , Jose Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores-Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes van der Velden , Sebastian Böttcher , Andrew Craig Rawstron , Ruth Mary de Tute , Ludovic Bernard Simon Lhermitte , Vahid Asnafi , Ester Mejstrikova , Tomasz Szczepanski , Paulo Jorge Monteiro Da Silva Lucio , Marta Martin Ayuso , Carlos Eduardo Pedreira
IPC分类号： G01N33/533 , G01N15/14 , G01N33/50 , G01N33/532
摘要： The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.
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公开(公告)号：US10942171B2
公开(公告)日：2021-03-09
申请号：US15849196
申请日：2017-12-20
发明人： Jacobus Johannes Maria van Dongen , Jose Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores-Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes van der Velden , Sebastian Böttcher , Andrew Craig Rawstron , Ruth Mary de Tute , Ludovic Bernard Simon Lhermitte , Vahid Asnafi , Ester Mejstrikova , Tomasz Szczepanski , Paulo Jorge Monteiro Da Silva Lucio , Marta Martín Ayuso , Carlos Eduardo Pedreira
IPC分类号： G01N33/533 , G01N15/14 , G01N33/50 , G01N33/532
摘要： The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.
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公开(公告)号：US12066441B2
公开(公告)日：2024-08-20
申请号：US17195416
申请日：2021-03-08
发明人： Jacobus Johannes Maria van Dongen , José Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores-Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes van der Velden , Sebastian Böttcher , Andrew Craig Rawstron , Ruth Mary de Tute , Ludovic Bernard Simon Lhermitte , Vahid Asnafi , Ester Mejstríková , Tomasz Szczepanski , Paulo Jorge Monteiro Da Silva Lucio , Marta Martin Ayuso , Carlos Eduardo Pedreira
IPC分类号： G01N33/533 , G01N15/14 , G01N33/49 , G01N33/50 , G01N33/532 , G01N33/569 , G01N15/1404
CPC分类号： G01N33/56972 , G01N15/14 , G01N33/4915 , G01N33/5005 , G01N33/5091 , G01N33/5094 , G01N33/532 , G01N33/533 , G01N2015/1402 , G01N2015/1413
摘要： The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.
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公开(公告)号：US20210177936A1
公开(公告)日：2021-06-17
申请号：US17085840
申请日：2020-10-30
发明人： Jacobus Johannes Maria van Dongen , José Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes Van der Velden , Sebastian Böttcher , Anthonie Willem Langerak , Ester Mejstríková , Tomasz Szczepanski , Matthias Ritgen , Paulo Jorge Monteiro Da Silva Lucio
IPC分类号： A61K38/16 , G01N33/574 , A61K38/17 , A61K39/02 , A61K39/09
摘要： The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ≥8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10−4, even down to 10−5. Also provided are diagnostic kits and methods for detecting MRD.
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公开(公告)号：US20180120301A1
公开(公告)日：2018-05-03
申请号：US15849196
申请日：2017-12-20
发明人： Jacobus Johannes Maria van Dongen , José Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores-Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes van der Velden , Sebastian Böttcher , Andrew Craig Rawstron , Ruth Mary de Tute , Ludovic Bernard Simon Lhermitte , Vahid Asnafi , Ester Mejstríková , Tomasz Szczepanski , Paulo Jorge Monteiro Da Silva Lucio , Marta Marin Ayuso , Carlos Eduardo Pedreira
IPC分类号： G01N33/50 , G01N33/532 , G01N33/533 , G01N15/14
摘要： The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.
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公开(公告)号：US20150160226A1
公开(公告)日：2015-06-11
申请号：US14407268
申请日：2013-06-14
发明人： Jacobus Johannes Maria van Dongen , Jose Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores Montero , Julia Maria Almeida Parra , Vincent Henricus Johnnes Van der Velden , Sebastian Bottcher , Anthonie Willem Langerak , Ester Mejstrikova , Tomasz Szczepanski , Matthias Ritgen , Paulo Jorge Monteiro Da Silva Lucio
IPC分类号： G01N33/574
CPC分类号： A61K38/164 , A61K38/1716 , A61K39/025 , A61K39/09 , G01N33/57426 , G01N33/57484
摘要： The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ≧8-color flow cytometric stainings as well as for 10-color and 12-color flow cytometric stainings, which can reach sensitivities of at least 10−4, even down to 10−5. Also provided are diagnostic kits and methods for detecting MRD.
摘要翻译： 本发明涉及最小残留病（MRD）诊断领域，该诊断逐步应用于血液恶性肿瘤患者如B细胞前体急性成淋巴细胞白血病（BCP-ALL），B- 细胞性慢性淋巴细胞白血病（B-CLL）和多发性骨髓瘤（MM）。 提供了独特的试剂组合物，其具有仔细选择和彻底测试的抗体组合，用于≥8色流式细胞术染色以及10色和12色流式细胞术染色，其可达到至少10-4的灵敏度，甚至 降至10-5。 还提供了用于检测MRD的诊断套件和方法。
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公开(公告)号：US20180140664A1
公开(公告)日：2018-05-24
申请号：US15812384
申请日：2017-11-14
发明人： Jacobus Johannes Maria van Dongen , José Alberto Orfao de Matos Correia e Vale , Juan Alejandro Flores Montero , Julia Maria Almeida Parra , Vincent Henricus Johannes Van der Velden , Sebastian Böttcher , Anthonie Willem Langerak , Ester Mejstriková , Tomasz Szczepanski , Matthias Ritgen , Paulo Jorge Monteiro Da Silva Lucio
CPC分类号： A61K38/164 , A61K38/1716 , A61K39/025 , A61K39/09 , G01N33/57426 , G01N33/57484
摘要： The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ≥8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10−4, even down to 10−5. Also provided are diagnostic kits and methods for detecting MRD.
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