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公开(公告)号：US20110223237A1
公开(公告)日：2011-09-15
申请号：US13045600
申请日：2011-03-11
申请人： Eri NISHIURA , Satoshi AMEYAMA , Koji NAKAMURA , Keigo INOSAKA , Mitsuhiko HORI
发明人： Eri NISHIURA , Satoshi AMEYAMA , Koji NAKAMURA , Keigo INOSAKA , Mitsuhiko HORI
IPC分类号： A61K9/70 , A61K31/135 , A61P25/16
CPC分类号： A61K9/7061 , A61K31/137
摘要： The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (−)-(R)—N,α-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive, an antioxidant and a metal hydroxide.
摘要翻译： 本发明提供一种粘合剂制剂，其包括背衬和形成在背衬的至少一侧上的压敏粘合剂层，该压敏粘合剂层含有（ - ） - （R）-N，α-二甲基 - N-2-丙炔基苯乙胺和/或其药学上可接受的盐，压敏粘合剂，抗氧化剂和金属氢氧化物。
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公开(公告)号：US20110223236A1
公开(公告)日：2011-09-15
申请号：US13045635
申请日：2011-03-11
申请人： Satoshi AMEYAMA , Eri NISHIURA , Koji NAKAMURA , Masashi KAMIYAMA , Hiroki MARUO , Kyoko HOSAKA , Mitsuhiko HORI
发明人： Satoshi AMEYAMA , Eri NISHIURA , Koji NAKAMURA , Masashi KAMIYAMA , Hiroki MARUO , Kyoko HOSAKA , Mitsuhiko HORI
IPC分类号： A61K9/70 , A61K31/135 , A61P25/16
CPC分类号： A61K9/7061 , A61K31/137 , A61K47/12 , A61K47/14
摘要： The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (−)-(R)—N,α-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive and a component which is liquid at 25° C. and has two or more ester bonds in one molecule thereof.
摘要翻译： 本发明提供一种粘合剂制剂，其包括背衬和形成在背衬的至少一侧上的压敏粘合剂层，该压敏粘合剂层含有（ - ） - （R）-N，α-二甲基 - N-2-丙炔基苯乙胺和/或其药学上可接受的盐，压敏粘合剂和在25℃下为液体并在其一个分子中具有两个或更多个酯键的组分。
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公开(公告)号：US20110243997A1
公开(公告)日：2011-10-06
申请号：US13073022
申请日：2011-03-28
申请人： Daisuke ASARI , Mitsuhiko HORI , Takuya SHISHIDO
发明人： Daisuke ASARI , Mitsuhiko HORI , Takuya SHISHIDO
IPC分类号： A61K31/185 , A61K38/06 , A61K31/522 , A61K9/14 , A61P11/08 , A61P11/10
CPC分类号： A61K9/7007 , A61K8/0241 , A61K9/0056
摘要： The present invention provides a film-form preparation having a rapid dissolution profile in the mouth and sufficient film strength, and also having excellent appearance and feel. More specifically, the present invention provides a film-form preparation including: a water-soluble and a polar organic solvent-soluble edible polymer; and polar organic solvent-insoluble drug particles.
摘要翻译： 本发明提供了一种在口中具有快速溶出曲线并具有足够的膜强度并且还具有优异外观和手感的膜形式。 更具体地说，本发明提供一种膜状制剂，其包括：水溶性和极性有机溶剂可溶性可食用聚合物; 和极性有机溶剂不溶性药物颗粒。
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公开(公告)号：US20110244047A1
公开(公告)日：2011-10-06
申请号：US13072972
申请日：2011-03-28
申请人： Daisuke ASARI , Mitsuhiko HORI , Takuya SHISHIDO
发明人： Daisuke ASARI , Mitsuhiko HORI , Takuya SHISHIDO
IPC分类号： A61K9/14 , A61K31/192
CPC分类号： A61K9/7007 , A61K9/0056 , A61K31/192 , A61K31/4045 , A61K31/405
摘要： The present invention provides a film-form preparation having a rapid dissolution profile in the mouth and sufficient film strength, and also having excellent appearance and feel. More specifically, the present invention provides a film-form preparation including: a water-soluble edible polymer; and water-insoluble drug particles, wherein an average particle size of the drug particles is 0.1 to 60 μm.
摘要翻译： 本发明提供了一种在口中具有快速溶出曲线并具有足够的膜强度并且还具有优异外观和手感的膜形式。 更具体地说，本发明提供一种膜状制剂，包括：水溶性可食用聚合物; 和水不溶性药物粒子，其中药物粒子的平均粒径为0.1〜60μm。
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公开(公告)号：US20110182993A1
公开(公告)日：2011-07-28
申请号：US13014245
申请日：2011-01-26
申请人： Daisuke ASARI , Mitsuhiko HORI , Takuya SHISHIDO
发明人： Daisuke ASARI , Mitsuhiko HORI , Takuya SHISHIDO
CPC分类号： A61K9/006 , A61K9/1623 , A61K9/7007 , A61K47/38
摘要： An object of the present invention is to provide a film-form preparation to be used in desensitization therapy and a method for producing the same. This film-form preparation enables the patient to self-administer an allergen and adjust the dose, has excellent portability, has no residual sensation, provides excellent protection against accidental swallowing, is easy for a caregiver to administer, and can greatly improve the QOL of both patients and caregivers. Additionally, this film-form preparation enables arbitrary control of the dissolution time in the mouth, particularly sublingually and has very little gummy sensation in the mouth and better feeling when touched by the fingers. A film-form preparation including: an allergen; an edible polymer that is soluble in both water and a polar organic solvent; and one or two or more types of particles selected from the group consisting of monosaccharide to hexasaccharide sugars and sugar alcohols thereof that have an average particle size of 0.1 to 100 μm.
摘要翻译： 本发明的目的是提供一种用于脱敏治疗的薄膜状制剂及其制造方法。 这种胶片形式的准备使患者能够自我管理过敏原并调整剂量，具有优异的便携性，无残留感，提供极好的防止意外吞咽的保护，容易让护理人员进行管理，并能大大提高生活质量 病人和护理人员。 此外，该膜形式的制备能够任意地控制口中的溶解时间，特别是舌下，并且在口中具有非常小的粘性感，并且当被手指触摸时具有更好的感觉。 一种膜形成制剂，包括：变应原; 可溶于水和极性有机溶剂的可食用聚合物; 以及选自平均粒径为0.1〜100μm的选自单糖至六糖的一种或两种以上的粒子及其糖醇。
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公开(公告)号：US20120294894A1
公开(公告)日：2012-11-22
申请号：US13475642
申请日：2012-05-18
申请人： Daisuke ASARI , Mitsuhiko HORI , Takuya SHISHIDO
发明人： Daisuke ASARI , Mitsuhiko HORI , Takuya SHISHIDO
摘要： An object of the present invention is to provide a pharmaceutical composition that allows stable storage and delivery of heat-labile allergens. The present invention provides a pharmaceutical composition containing: an allergen; and at least one selected from the group consisting of an organic acid salt, an inorganic acid salt, and a pH adjuster.
摘要翻译： 本发明的目的是提供一种药物组合物，其能够稳定地储存和递送热不稳定的过敏原。 本发明提供一种药物组合物，其含有：变应原; 和选自有机酸盐，无机酸盐和pH调节剂中的至少一种。
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公开(公告)号：US20120171251A1
公开(公告)日：2012-07-05
申请号：US13314500
申请日：2011-12-08
CPC分类号： A61K39/36 , A61K9/0056 , A61K9/7007 , A61K47/26 , A61K47/42 , A61K2039/54
摘要： The present invention provides a sheet-form preparation that can be easily dissolved intraorally, allows the dissolution time thereof to be easily controlled, and can stably contain an allergenic protein from cedar pollen.The sheet-form preparation contains water, gelatin, an allergenic protein from cedar pollen, and a stabilizing agent of the allergenic protein from cedar pollen.
摘要翻译： 本发明提供一种片状制剂，其可以容易地溶解，允许容易地控制其溶解时间，并能稳定地含有来自雪松花粉的过敏原蛋白质。 片状制剂含有水，明胶，来自雪松花粉的变应原蛋白，以及来自雪松花粉的过敏性蛋白质的稳定剂。
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公开(公告)号：US20120148656A1
公开(公告)日：2012-06-14
申请号：US13314662
申请日：2011-12-08
IPC分类号： A61K9/70 , A61K38/28 , A61K39/00 , A61K31/422
CPC分类号： A61K38/014 , A61K9/0056 , A61K9/7007 , A61K31/00 , A61K47/26 , A61K47/42
摘要： The present invention provides a sheet-form preparation that can be easily dissolved intraorally, allows the dissolution time thereof to be easily controlled, and can stably contain a drug except an allergenic protein from cedar pollen. The sheet-form preparation contains water, gelatin, and a drug except an allergenic protein from cedar pollen.
摘要翻译： 本发明提供一种易于口服溶解的片状制剂，容易控制其溶解时间，并能够稳定地含有来自雪松花粉的过敏性蛋白质以外的药物。 片状制剂含有水，明胶和除了来自雪松花粉的过敏性蛋白质以外的药物。
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公开(公告)号：US20120308662A1
公开(公告)日：2012-12-06
申请号：US13483190
申请日：2012-05-30
CPC分类号： A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5073 , A61K31/18 , A61K31/185
摘要： The present invention aims to provide a particulate formulation with an effectively controlled dissolution characteristic of a drug even if the average particle diameter is small. The present invention provides a particulate formulation containing drug particles and a first coating layer coating the drug particles and characterized in that the first coating layer contains a water-insoluble polymer, inorganic particles, and/or a lipid component and the lipid component contains a C15 or higher fatty acid.
摘要翻译： 本发明的目的在于提供即使平均粒径小的药物的有效控制的溶出特性的微粒制剂。 本发明提供含有药物颗粒和涂覆药物颗粒的第一涂层的颗粒制剂，其特征在于第一涂层含有水不溶性聚合物，无机颗粒和/或脂质组分，脂质组分含有C15 或高级脂肪酸。
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10.发明申请EDIBLE JELLY-FORM COMPOSITION, JELLY-FORM PREPARATION AND METHOD FOR PRODUCING JELLY-FORM PREPARATION 审中-公开可食用形状组合物，制备和制备果胶形式的制备方法公开(公告)号：US20120294893A1
公开(公告)日：2012-11-22
申请号：US13475207
申请日：2012-05-18
IPC分类号： A23L1/05 , A23L1/0532 , A23L1/0524 , A23L1/053 , A61P37/08 , A61K47/42 , A61K47/36 , A61K39/36 , A61K39/35 , A23L1/0562 , A23L1/054
CPC分类号： A61K9/006 , A61K9/0056 , A61K47/10 , A61K47/36 , A61K47/42
摘要： The present invention aims to provide a jelly (as a result, easy-to-swallow), intraorally soluble edible jelly composition although it is preferably free of water. The present invention relates to an edible jelly composition including: a gelling agent; and a nonvolatile organic solvent compatible with the gelling agent.
摘要翻译： 本发明的目的是提供一种果冻（因此易于吞咽），溶解性可溶的可食果冻组合物，尽管其优选不含水。 本发明涉及可食用果冻组合物，其包含：胶凝剂; 和与胶凝剂相容的非挥发性有机溶剂。
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