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    Adhesive preparation containing fentanyl
    1.
    发明授权
    Adhesive preparation containing fentanyl 有权
    含芬太尼的粘合剂

    公开(公告)号：US08591939B2

    公开(公告)日：2013-11-26

    申请号：US11196935

    申请日：2005-08-04

    申请人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

    发明人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

    IPC分类号： A61K31/445 ,  A61F13/02

    CPC分类号： A61K9/7053 ,  A61K31/4468

    摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

    摘要翻译： 本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性 种类具有不同分子量的聚异丁烯，增粘剂和有机液体。 具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体 两种聚异丁烯和上述增粘剂。

    FILM-FORM PREPARATION AND METHOD FOR PRODUCING THE SAME
    2.
    发明申请
    FILM-FORM PREPARATION AND METHOD FOR PRODUCING THE SAME 审中-公开
    膜形式制备及其制备方法

    公开(公告)号：US20110244047A1

    公开(公告)日：2011-10-06

    申请号：US13072972

    申请日：2011-03-28

    申请人： Daisuke ASARI ,  Mitsuhiko HORI ,  Takuya SHISHIDO

    发明人： Daisuke ASARI ,  Mitsuhiko HORI ,  Takuya SHISHIDO

    IPC分类号： A61K9/14 ,  A61K31/192

    CPC分类号： A61K9/7007 ,  A61K9/0056 ,  A61K31/192 ,  A61K31/4045 ,  A61K31/405

    摘要： The present invention provides a film-form preparation having a rapid dissolution profile in the mouth and sufficient film strength, and also having excellent appearance and feel. More specifically, the present invention provides a film-form preparation including: a water-soluble edible polymer; and water-insoluble drug particles, wherein an average particle size of the drug particles is 0.1 to 60 μm.

    摘要翻译： 本发明提供了一种在口中具有快速溶出曲线并具有足够的膜强度并且还具有优异外观和手感的膜形式。 更具体地说，本发明提供一种膜状制剂，包括：水溶性可食用聚合物; 和水不溶性药物粒子，其中药物粒子的平均粒径为0.1〜60μm。

    FILM-FORM PREPARATION
    3.
    发明申请
    FILM-FORM PREPARATION 有权
    电影制作

    公开(公告)号：US20110182993A1

    公开(公告)日：2011-07-28

    申请号：US13014245

    申请日：2011-01-26

    申请人： Daisuke ASARI ,  Mitsuhiko HORI ,  Takuya SHISHIDO

    发明人： Daisuke ASARI ,  Mitsuhiko HORI ,  Takuya SHISHIDO

    IPC分类号： A61K9/14 ,  A61K39/35 ,  A61P37/08

    CPC分类号： A61K9/006 ,  A61K9/1623 ,  A61K9/7007 ,  A61K47/38

    摘要： An object of the present invention is to provide a film-form preparation to be used in desensitization therapy and a method for producing the same. This film-form preparation enables the patient to self-administer an allergen and adjust the dose, has excellent portability, has no residual sensation, provides excellent protection against accidental swallowing, is easy for a caregiver to administer, and can greatly improve the QOL of both patients and caregivers. Additionally, this film-form preparation enables arbitrary control of the dissolution time in the mouth, particularly sublingually and has very little gummy sensation in the mouth and better feeling when touched by the fingers. A film-form preparation including: an allergen; an edible polymer that is soluble in both water and a polar organic solvent; and one or two or more types of particles selected from the group consisting of monosaccharide to hexasaccharide sugars and sugar alcohols thereof that have an average particle size of 0.1 to 100 μm.

    摘要翻译： 本发明的目的是提供一种用于脱敏治疗的薄膜状制剂及其制造方法。 这种胶片形式的准备使患者能够自我管理过敏原并调整剂量，具有优异的便携性，无残留感，提供极好的防止意外吞咽的保护，容易让护理人员进行管理，并能大大提高生活质量 病人和护理人员。 此外，该膜形式的制备能够任意地控制口中的溶解时间，特别是舌下，并且在口中具有非常小的粘性感，并且当被手指触摸时具有更好的感觉。 一种膜形成制剂，包括：变应原; 可溶于水和极性有机溶剂的可食用聚合物; 以及选自平均粒径为0.1〜100μm的选自单糖至六糖的一种或两种以上的粒子及其糖醇。

    Preparation for transdermal drug administration
    7.
    发明授权
    Preparation for transdermal drug administration 失效
    透皮给药制剂

    公开(公告)号：US5368860A

    公开(公告)日：1994-11-29

    申请号：US798149

    申请日：1991-11-26

    申请人： Masaki Sunami ,  Koji Maruyama ,  Mitsuhiko Hori ,  Shoichi Tokuda ,  Kenichiro Saito ,  Ikuo Kishi

    发明人： Masaki Sunami ,  Koji Maruyama ,  Mitsuhiko Hori ,  Shoichi Tokuda ,  Kenichiro Saito ,  Ikuo Kishi

    IPC分类号： A61K9/70 ,  A61K31/165 ,  A61K31/245 ,  A61K31/46 ,  A61K31/47 ,  A61K45/00 ,  A61P23/02 ,  A61P25/02 ,  A61P25/04 ,  A61F13/02

    CPC分类号： A61K9/7061 ,  A61K31/165

    摘要： A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.

    摘要翻译： 用于经皮给药的制剂包括柔性背衬层和含有40-65重量％比例的局部麻醉剂的压敏粘合剂层。 由于粘合剂层中未溶解的局部麻醉剂（Ac）与溶解的局部麻醉剂（As）Ac / As的比例确定为0.1-1.8，所以制剂 对于本发明的透皮给药，自身粘合性优异，从皮肤上除去时没有粘合剂。 此外，在施用于皮肤之后立即从压敏粘合剂层中爆发出的未溶解药物的释放允许快速出现麻醉效果，这使得本发明的制剂能够广泛的临床应用。