公开(公告)号：US20080221842A1

公开(公告)日：2008-09-11

申请号：US12052597

申请日：2008-03-20

申请人： Eric Gard ,  Vincent Riot ,  Keith Coffee ,  Bruce Woods ,  Herbert Tobias ,  Jim Birch ,  Todd Weisgraber

发明人： Eric Gard ,  Vincent Riot ,  Keith Coffee ,  Bruce Woods ,  Herbert Tobias ,  Jim Birch ,  Todd Weisgraber

IPC分类号： G06F17/50 ,  G06F17/10

CPC分类号： G01N1/24 ,  G01N1/22 ,  G01N2001/2223 ,  G01N2001/244 ,  G01N2015/0026 ,  G01N2015/0046

摘要： A computerized method and system for designing an aerodynamic focusing lens stack, using input from a designer related to, for example, particle size range to be considered, characteristics of the gas to be flowed through the system, the upstream temperature and pressure at the top of a first focusing lens, the flow rate through the aerodynamic focusing lens stack equivalent at atmosphere pressure; and a Stokes number range. Based on the design parameters, the method and system determines the total number of focusing lenses and their respective orifice diameters required to focus the particle size range to be considered, by first calculating for the orifice diameter of the first focusing lens in the Stokes formula, and then using that value to determine, in iterative fashion, intermediate flow values which are themselves used to determine the orifice diameters of each succeeding focusing lens in the stack design, with the results being output to a designer. In addition, the Reynolds numbers associated with each focusing lens as well as exit nozzle size may also be determined to enhance the stack design.

摘要翻译： 用于设计空气动力学聚焦透镜叠层的计算机化方法和系统，使用来自设计者的输入，例如要考虑的粒度范围，要流过系统的气体的特性，顶部的上游温度和压力 的第一聚焦透镜，通过空气动力学聚焦透镜叠层在大气压下相当的流速; 和斯托克斯号码范围。 基于设计参数，方法和系统通过首先计算斯托克斯公式中的第一聚焦透镜的孔直径来确定聚焦透镜的总数及其相应的孔径直径，以聚焦要考虑的粒度范围， 然后使用该值以迭代方式确定本身用于确定堆叠设计中每个后续聚焦透镜的孔口直径的中间流量值，其结果被输出给设计者。 此外，还可以确定与每个聚焦透镜相关联的雷诺数以及出口喷嘴尺寸以增强堆叠设计。

公开(公告)号：US08065119B2

公开(公告)日：2011-11-22

申请号：US12052597

申请日：2008-03-20

申请人： Eric Gard ,  Vincent Riot ,  Keith Coffee ,  Bruce Woods ,  Herbert Tobias ,  Jim Birch ,  Todd Weisgraber

发明人： Eric Gard ,  Vincent Riot ,  Keith Coffee ,  Bruce Woods ,  Herbert Tobias ,  Jim Birch ,  Todd Weisgraber

IPC分类号： G06F17/50

CPC分类号： G01N1/24 ,  G01N1/22 ,  G01N2001/2223 ,  G01N2001/244 ,  G01N2015/0026 ,  G01N2015/0046

摘要： A computerized method and system for designing an aerodynamic focusing lens stack, using input from a designer related to, for example, particle size range to be considered, characteristics of the gas to be flowed through the system, the upstream temperature and pressure at the top of a first focusing lens, the flow rate through the aerodynamic focusing lens stack equivalent at atmosphere pressure; and a Stokes number range. Based on the design parameters, the method and system determines the total number of focusing lenses and their respective orifice diameters required to focus the particle size range to be considered, by first calculating for the orifice diameter of the first focusing lens in the Stokes formula, and then using that value to determine, in iterative fashion, intermediate flow values which are themselves used to determine the orifice diameters of each succeeding focusing lens in the stack design, with the results being output to a designer. In addition, the Reynolds numbers associated with each focusing lens as well as exit nozzle size may also be determined to enhance the stack design.

摘要翻译： 用于设计空气动力学聚焦透镜叠层的计算机化方法和系统，使用来自设计者的输入，例如要考虑的粒度范围，要流过系统的气体的特性，顶部的上游温度和压力 的第一聚焦透镜，通过空气动力学聚焦透镜叠层在大气压下相当的流速; 和斯托克斯号码范围。 基于设计参数，方法和系统通过首先计算斯托克斯公式中的第一聚焦透镜的孔直径来确定聚焦透镜的总数及其相应的孔径直径，以聚焦要考虑的粒度范围， 然后使用该值以迭代方式确定本身用于确定堆叠设计中每个后续聚焦透镜的孔口直径的中间流量值，其结果被输出给设计者。 此外，还可以确定与每个聚焦透镜相关联的雷诺数以及出口喷嘴尺寸以增强堆叠设计。

公开(公告)号：US07361891B2

公开(公告)日：2008-04-22

申请号：US11471093

申请日：2006-06-19

申请人： Eric Gard ,  Vincent Riot ,  Keith Coffee ,  Bruce Woods ,  Herbert Tobias ,  Jim Birch ,  Todd Weisgraber

发明人： Eric Gard ,  Vincent Riot ,  Keith Coffee ,  Bruce Woods ,  Herbert Tobias ,  Jim Birch ,  Todd Weisgraber

IPC分类号： H01J37/301 ,  H01J49/00 ,  G01N1/22 ,  G01N30/72

CPC分类号： G01N1/24 ,  G01N1/22 ,  G01N2001/2223 ,  G01N2001/244 ,  G01N2015/0026 ,  G01N2015/0046

摘要： A pressure-flow reducer, and an aerosol focusing system incorporating such a pressure-flow reducer, for performing high-flow, atmosphere-pressure sampling while delivering a tightly focused particle beam in vacuum via an aerodynamic focusing lens stack. The pressure-flow reducer has an inlet nozzle for adjusting the sampling flow rate, a pressure-flow reduction region with a skimmer and pumping ports for reducing the pressure and flow to enable interfacing with low pressure, low flow aerosol focusing devices, and a relaxation chamber for slowing or stopping aerosol particles. In this manner, the pressure-flow reducer decouples pressure from flow, and enables aerosol sampling at atmospheric pressure and at rates greater than 1 liter per minute.

摘要翻译： 一种压力减流器和一种包含这种压力减流器的气溶胶聚焦系统，用于在通过空气动力学聚焦透镜叠层在真空中输送紧密聚焦的粒子束的同时执行高流量大气压力采样。 压力减流器具有用于调节采样流量的入口喷嘴，具有撇渣器的压力流动减少区域和用于减小压力和流量的泵送端口，使得能够与低压，低流量气溶胶聚焦装置进行接口以及松弛 用于减缓或停止气溶胶颗粒的室。 以这种方式，压力流减少器将压力与流动分离，并且能够在大气压力和大于每分钟1升的速率下进行气溶胶取样。

公开(公告)号：US20070023644A1

公开(公告)日：2007-02-01

申请号：US11471093

申请日：2006-06-19

申请人： Eric Gard ,  Vincent Riot ,  Keith Coffee ,  Bruce Woods ,  Herbert Tobias ,  Jim Birch ,  Todd Weisgraber

发明人： Eric Gard ,  Vincent Riot ,  Keith Coffee ,  Bruce Woods ,  Herbert Tobias ,  Jim Birch ,  Todd Weisgraber

IPC分类号： H01J49/00

CPC分类号： G01N1/24 ,  G01N1/22 ,  G01N2001/2223 ,  G01N2001/244 ,  G01N2015/0026 ,  G01N2015/0046

摘要： A pressure-flow reducer, and an aerosol focusing system incorporating such a pressure-flow reducer, for performing high-flow, atmosphere-pressure sampling while delivering a tightly focused particle beam in vacuum via an aerodynamic focusing lens stack. The pressure-flow reducer has an inlet nozzle for adjusting the sampling flow rate, a pressure-flow reduction region with a skimmer and pumping ports for reducing the pressure and flow to enable interfacing with low pressure, low flow aerosol focusing devices, and a relaxation chamber for slowing or stopping aerosol particles. In this manner, the pressure-flow reducer decouples pressure from flow, and enables aerosol sampling at atmospheric pressure and at rates greater than 1 liter per minute.

摘要翻译： 一种压力减流器和一种包含这种压力减流器的气溶胶聚焦系统，用于在通过空气动力学聚焦透镜叠层在真空中输送紧密聚焦的粒子束的同时执行高流量大气压力采样。 压力减流器具有用于调节采样流量的入口喷嘴，具有撇渣器的压力流动减少区域和用于减小压力和流量的泵送端口，使得能够与低压，低流量气溶胶聚焦装置进行接口以及松弛 用于减缓或停止气溶胶颗粒的室。 以这种方式，压力流减少器将压力与流动分离，并且能够在大气压力和大于每分钟1升的速率下进行气溶胶取样。

公开(公告)号：US20050073683A1

公开(公告)日：2005-04-07

申请号：US10916737

申请日：2004-08-11

申请人： Eric Gard ,  Keith Coffee ,  Matthias Frank ,  Herbert Tobias ,  David Fergenson ,  Norm Madden ,  Vincent Riot ,  Paul Steele ,  Bruce Woods

发明人： Eric Gard ,  Keith Coffee ,  Matthias Frank ,  Herbert Tobias ,  David Fergenson ,  Norm Madden ,  Vincent Riot ,  Paul Steele ,  Bruce Woods

IPC分类号： G01N21/00

CPC分类号： H01J49/164 ,  H01J49/0445 ,  H01J49/40

摘要： An improved method and system of identifying individual aerosol particles in real time. Sample aerosol particles are collimated, tracked, and screened to determine which ones qualify for mass spectrometric analysis based on predetermined qualification or selection criteria. Screening techniques include one or more of determining particle size, shape, symmetry, and fluorescence. Only qualifying particles passing all screening criteria are subject to desorption/ionization and single particle mass spectrometry to produce corresponding test spectra, which is used to determine the identities of each of the qualifying aerosol particles by comparing the test spectra against predetermined spectra for known particle types. In this manner, activation cycling of a particle ablation laser of a single particle mass spectrometer is reduced.

摘要翻译： 一种改进的实时识别单个气溶胶颗粒的方法和系统。 样品气溶胶颗粒被准直，跟踪和筛选，以确定哪些符合基于预定资格或选择标准的质谱分析。 筛选技术包括确定粒度，形状，对称性和荧光的一种或多种。 只有通过所有筛选标准的合格粒子才能进行解吸/电离和单粒子质谱，以产生相应的测试光谱，用于通过将测试光谱与已知粒子类型的预定光谱进行比较来确定每个合格气溶胶颗粒的身份 。 以这种方式，降低了单粒子质谱仪的粒子消融激光的激活循环。