公开(公告)号：US08293904B2

公开(公告)日：2012-10-23

申请号：US13236838

申请日：2011-09-20

申请人： Eric R. Diebold ,  Mitali Ghoshal ,  David Z. Deng ,  Jane S. C. Tsai

发明人： Eric R. Diebold ,  Mitali Ghoshal ,  David Z. Deng ,  Jane S. C. Tsai

IPC分类号： C07F15/00 ,  G01N27/26 ,  C07K14/00

CPC分类号： G01N33/5306 ,  C07F15/002 ,  C07F15/0026 ,  C12Q1/004 ,  G01N33/5438 ,  G01N2458/30

摘要： The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.

公开(公告)号：US08288544B2

公开(公告)日：2012-10-16

申请号：US10555138

申请日：2004-07-01

申请人： Eric R. Diebold ,  Mitali Ghoshal ,  David Z. Deng ,  Jane S.C. Tsai

发明人： Eric R. Diebold ,  Mitali Ghoshal ,  David Z. Deng ,  Jane S.C. Tsai

IPC分类号： C07F15/00 ,  G01N27/26 ,  C07K14/00

CPC分类号： G01N33/5306 ,  C07F15/002 ,  C07F15/0026 ,  C12Q1/004 ,  G01N33/5438 ,  G01N2458/30

摘要： The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.

摘要翻译： 本发明提供用于使用免疫学技术检测多种分析物的新型锇基电化学物质。 本发明还提供了可与锇基电化学物质一起使用的支持电极结构的诊断试剂盒和测试传感器。 可以制造测试传感器以支持指数的电极阵列，其被设计为提供期望分析可能以低浓度存在的分析物的电信号放大的放大。

公开(公告)号：US08529741B2

公开(公告)日：2013-09-10

申请号：US13403318

申请日：2012-02-23

申请人： Gary T. Neel ,  Douglas E. Bell ,  Dennis Slomski ,  David Z. Deng

发明人： Gary T. Neel ,  Douglas E. Bell ,  Dennis Slomski ,  David Z. Deng

IPC分类号： G01N27/327

CPC分类号： A61B5/14546 ,  A61B5/14535 ,  A61B5/1486 ,  A61B2560/0209 ,  A61B2562/0295 ,  A61B2562/085 ,  C12Q1/006 ,  G01N27/3272 ,  G01N27/3274 ,  G01N33/66 ,  Y10T29/49117

摘要： Methods and devices for determining the concentration of a constituent in a physiological sample are provided. The blood sample is introduced into a test strip with portions of the blood sample being directed to both a first capillary and a second capillary. The first capillary configured to electrochemically determine a concentration of a first analyte in a blood sample by measuring a signal across a set of electrodes. The second capillary is configured to determine a hematocrit value of the blood sample by measuring a signal across a second set of electrodes.

摘要翻译： 提供了用于确定生理样品中成分浓度的方法和装置。 将血液样品引入测试条中，其中部分血液样品被引导到第一毛细管和第二毛细管。 第一毛细管构造成通过测量跨越一组电极的信号来电化学地确定血液样品中的第一分析物的浓度。 第二毛细管被配置为通过测量跨越第二组电极的信号来确定血液样品的血细胞比容值。

公开(公告)号：US20120241318A1

公开(公告)日：2012-09-27

申请号：US13403318

申请日：2012-02-23

申请人： Gary T. Neel ,  Douglas E. Bell ,  Dennis Slomski ,  David Z. Deng

发明人： Gary T. Neel ,  Douglas E. Bell ,  Dennis Slomski ,  David Z. Deng

IPC分类号： G01N27/327 ,  H05K13/00 ,  G01N33/50

CPC分类号： A61B5/14546 ,  A61B5/14535 ,  A61B5/1486 ,  A61B2560/0209 ,  A61B2562/0295 ,  A61B2562/085 ,  C12Q1/006 ,  G01N27/3272 ,  G01N27/3274 ,  G01N33/66 ,  Y10T29/49117

摘要： Methods and devices for determining the concentration of a constituent in a physiological sample are provided. The blood sample is introduced into a test strip with portions of the blood sample being directed to both a first capillary and a second capillary. The first capillary configured to electrochemically determine a concentration of a first analyte in a blood sample by measuring a signal across a set of electrodes. The second capillary is configured to determine a hematocrit value of the blood sample by measuring a signal across a second set of electrodes.

摘要翻译： 提供了用于确定生理样品中成分浓度的方法和装置。 将血液样品引入测试条中，其中部分血液样品被引导到第一毛细管和第二毛细管。 第一毛细管构造成通过测量跨越一组电极的信号来电化学地确定血液样品中的第一分析物的浓度。 第二毛细管被配置为通过测量跨越第二组电极的信号来确定血液样品的血细胞比容值。