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公开(公告)号：US07815931B2
公开(公告)日：2010-10-19
申请号：US12326373
申请日：2008-12-02
IPC分类号： A61F13/00
摘要： An improved skin substitute is presented comprised of non-biological materials produced with a series of regularly-spaced pores and a nylon weave netting. The top component is a thin (approximately 0.001″ thick) silicone elastomer in which pore holes have been vacuum-pulled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/1 denier); incorporated into the silicone/nylon structure are collagen peptides [about 10 micrograms per square centimeter of Porcine type 1—“the active component”] without cross-linking agent to enable a quick interaction with fibrin in the wound to achieve acute adherence. The vacuum-pulled holes provide a range of porosities to ensure minimum fluid accumulation beneath the skin substitute without wound desiccation. The range of hole diameters preferred in the present invention is 0.75 mm to 1.05 mm and at holes centered at ¼″-⅓″. Providing a structure that has better acute adherence and minimal fluid accumulation beneath the Temporary Skin Substitute, which will reduce infection complications and maximize wound healing. Larger pieces of this skin substitute can be made to cover larger wounds, unlike previous skin substitutes.
摘要翻译： 提出了一种改进的皮肤替代品，包括由一系列规则间隔的孔和尼龙编织网生产的非生物材料。 顶部组分是薄（约0.001“厚）硅氧烷弹性体，其中孔孔已被真空拉拔; 物理上附着于硅氧烷弹性体的是精细针织尼龙织物（12/1,15/1旦尼尔）; 掺入硅酮/尼龙结构中的是胶原肽[约10微克每平方厘米的猪类型1-“活性组分”]，无交联剂，以使与伤口中的纤维蛋白快速相互作用以达到急性依从性。 真空拉孔提供一系列的孔隙度，以确保在皮肤替代物下面的最小的液体积聚而无伤口干燥。 在本发明中优选的孔直径的范围是0.75mm至1.05mm，在以“1/3”为中心的孔中。 提供在临时皮肤替代物下具有更好的急性依从性和最小的液体积聚的结构，其将减少感染并发症并最大限度地伤口愈合。 与以前的皮肤替代品不同，这种皮肤替代物的较大片可以覆盖较大的伤口。
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公开(公告)号：US20090232878A1
公开(公告)日：2009-09-17
申请号：US12326373
申请日：2008-12-02
摘要： An improved skin substitute is presented comprised of non-biological materials produced with a series of regularly-spaced pores and a nylon weave netting. The top component is a thin (approximately 0.001″ thick) silicone elastomer in which pore holes have been vacuum-pulled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/1 denier); incorporated into the silicone/nylon structure are collagen peptides [about 10 micrograms per square centimeter of Porcine type 1—“the active component”] without cross-linking agent to enable a quick interaction with fibrin in the wound to achieve acute adherence.The vacuum-pulled holes provide a range of porosities to ensure minimum fluid accumulation beneath the skin substitute without wound desiccation. The range of hole diameters preferred in the present invention is 0.75 mm to 1.05 mm and at holes centered at ¼″-⅓″. Providing a structure that has better acute adherence and minimal fluid accumulation beneath the Temporary Skin Substitute, which will reduce infection complications and maximize wound healing. Larger pieces of this skin substitute can be made to cover larger wounds, unlike previous skin substitutes.
摘要翻译： 提出了一种改进的皮肤替代品，包括由一系列规则间隔的孔和尼龙编织网生产的非生物材料。 顶部组分是薄（约0.001“厚）的有机硅弹性体，其中孔孔已被真空拉制; 物理上附着于硅氧烷弹性体的是精细针织尼龙织物（12/1,15/1旦尼尔）; 掺入硅酮/尼龙结构中的是胶原肽[约10微克每平方厘米的猪类型1-“活性组分”]，无交联剂，以使与伤口中的纤维蛋白快速相互作用以达到急性依从性。 真空拉孔提供一系列的孔隙度，以确保在皮肤替代物下面的最小的液体积聚而无伤口干燥。 在本发明中优选的孔直径的范围是0.75mm至1.05mm，在以1/4“-1 / 3”为中心的孔中。 提供在临时皮肤替代物下具有更好的急性依从性和最小的液体积聚的结构，其将减少感染并发症并最大限度地伤口愈合。 与以前的皮肤替代品不同，这种皮肤替代物的较大片可以覆盖较大的伤口。
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3.发明申请TEMPORARY SKIN SUBSTITUTE COMPRISED OF BIOLOGICAL COMPOUNDS OF PLANT AND ANIMAL ORIGINS 审中-公开由植物和动物原始生物化学组成的临时皮肤替代物公开(公告)号：US20090234305A1
公开(公告)日：2009-09-17
申请号：US12348412
申请日：2009-01-05
IPC分类号： A61F13/00
CPC分类号： A61L27/18 , A61F13/00008 , A61F13/00021 , A61F13/00063 , A61F2013/00157 , A61F2013/00382 , A61F2013/00527 , A61F2013/00553 , A61F2013/00927 , A61L27/56 , A61L27/60 , C08L83/04 , C08L77/00
摘要： An improved skin substitute is presented comprised of non-biological materials produced with a series of regularly-spaced pores and a nylon mesh netting. The top component is a thin (approximately 0.001″ thick) silicone elastomer in which pore holes have been vacuum-pulled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/2 denier); incorporated into the silicone/nylon structure are several wound healing agents, including Vitamin E, Vitamin C, Chondroitin 4 Sulfate, Chondroitin 6 Sulfate and Immuno-10 (a highly purified fraction of Aloe Vera) in addition to porcine collagen peptide.The holes in the skin substitute provide a range of porosities to ensure minimum fluid accumulation beneath the skin substitute without wound desiccation. The three-dimensional nature of the nylon mesh in addition to the use of collagen peptides provides better acute adherence with a structure that supports the growth of new skin cells. The range of hole diameters preferred in the present invention is 0.75 mm to 1.05 mm and at holes centered at ¼″-⅓″, providing minimal fluid accumulation beneath the Temporary Skin Substitute, which will reduce infection complications and maximize wound healing.
摘要翻译： 提出了一种改进的皮肤替代品，其包括由一系列规则间隔的孔和尼龙网状网制成的非生物材料。 顶部组分是薄（约0.001“厚）的有机硅弹性体，其中孔孔已被真空拉制; 物理上附着于有机硅弹性体的是细针织尼龙织物（12 / 1,15 / 2旦尼尔）; 含有维生素E，维生素C，硫酸软骨素4，硫酸软骨素6和免疫10（高纯度芦荟成分）除了猪胶原肽外，还含有几种伤口愈合剂。 皮肤替代品中的孔提供一系列孔隙度，以确保皮肤替代物下方的最小液体积聚而不伤口干燥。 除了使用胶原肽之外，尼龙网的三维性质提供了与支持新皮肤细胞生长的结构的更好的急性粘附。 在本发明中优选的孔直径的范围是0.75mm至1.05mm，在以“1/3”至1/3“为中心的孔中，在临时皮肤替代物之下提供最小的流体积聚，这将减少感染并发症并最大限度地伤口愈合 。
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公开(公告)号：US20150165636A1
公开(公告)日：2015-06-18
申请号：US14524752
申请日：2014-10-27
CPC分类号： B26F1/20 , A61F13/0276 , A61L15/26 , A61L15/325 , A61L15/40 , A61L15/425 , A61L2300/30 , B26D1/405 , B26D1/626 , B26D11/00 , Y10T83/0481 , Y10T83/4798 , C08L83/04
摘要： A mechanism and a method for slitting silicone membranes using automated slitting blades is presented. The pattern of slits in the membrane can be adjusted by using a cutting cylinder comprised of a plurality of circular cutting gears assembled in parallel.The cutting cylinder is of indefinite length, but in the preferred embodiment is approximately 15″ long and 3″ in diameter. The silicone membrane can range in thickness from 0.005″ to 0.01″ inch.
摘要翻译： 提出了使用自动切割刀片切割硅酮膜的机理和方法。 可以通过使用由并联组装的多个圆形切割齿轮组成的切割滚筒来调节膜中的狭缝的图案。 切割圆筒的长度是不确定的，但是在优选的实施例中，直径大约为15“长和3”。 硅酮膜的厚度可以在0.005“至0.01”英寸的范围内。
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