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    Synthetic membrane for wound-dressings
    4.
    发明授权
    Synthetic membrane for wound-dressings 失效
    伤口敷料合成膜

    公开(公告)号：US4161948A

    公开(公告)日：1979-07-24

    申请号：US869688

    申请日：1978-01-16

    申请人： Daniel Bichon

    发明人： Daniel Bichon

    IPC分类号： B32B5/18 ,  A61F13/00 ,  A61L15/32 ,  A61L15/64 ,  A61L27/60 ,  C08J9/28 ,  D06N3/12

    CPC分类号： A61L15/32 ,  A61L15/64 ,  A61L27/60 ,  A61F2013/00527 ,  Y10S602/90 ,  Y10T428/249961 ,  Y10T428/31725

    摘要： Artificial membrane for wound-dressings composed of two polypeptide layers, one of which at least, the inside layer which contacts the wound, is biologically resorbable and the outside layer has an asymmetric structure permeable to water and to drug solutions but pratically impervious to outside pathogenic agents. The inside layer, at least, is constituted from biodegradable copolymers of amino-acids and -diacids of which the --COOH functions are partially esterified with mono and/or di-ols.

    摘要翻译： 用于由两个多肽层组成的伤口敷料的人造膜，其中至少一个与伤口接触的内层是生物可吸收的，并且外层具有对水和药物溶液可渗透的不对称结构，但是不透外部致病性 代理商 至少内层由氨基酸的生物降解性共聚物和-COOH功能部分用单和/或二酯部分酯化的二酸形成。

    TEMPORARY SKIN SUBSTITUTE COMPRISED OF BIOLOGICAL COMPOUNDS OF PLANT AND ANIMAL ORIGINS
    6.
    发明申请
    TEMPORARY SKIN SUBSTITUTE COMPRISED OF BIOLOGICAL COMPOUNDS OF PLANT AND ANIMAL ORIGINS 审中-公开
    由植物和动物原始生物化学组成的临时皮肤替代物

    公开(公告)号：US20090234305A1

    公开(公告)日：2009-09-17

    申请号：US12348412

    申请日：2009-01-05

    申请人： Ernest Aubrey Woodroof

    发明人： Ernest Aubrey Woodroof

    IPC分类号： A61F13/00

    CPC分类号： A61L27/18 ,  A61F13/00008 ,  A61F13/00021 ,  A61F13/00063 ,  A61F2013/00157 ,  A61F2013/00382 ,  A61F2013/00527 ,  A61F2013/00553 ,  A61F2013/00927 ,  A61L27/56 ,  A61L27/60 ,  C08L83/04 ,  C08L77/00

    摘要： An improved skin substitute is presented comprised of non-biological materials produced with a series of regularly-spaced pores and a nylon mesh netting. The top component is a thin (approximately 0.001″ thick) silicone elastomer in which pore holes have been vacuum-pulled; physically attached to the silicone elastomer is a fine knitted nylon fabric (12/1, 15/2 denier); incorporated into the silicone/nylon structure are several wound healing agents, including Vitamin E, Vitamin C, Chondroitin 4 Sulfate, Chondroitin 6 Sulfate and Immuno-10 (a highly purified fraction of Aloe Vera) in addition to porcine collagen peptide.The holes in the skin substitute provide a range of porosities to ensure minimum fluid accumulation beneath the skin substitute without wound desiccation. The three-dimensional nature of the nylon mesh in addition to the use of collagen peptides provides better acute adherence with a structure that supports the growth of new skin cells. The range of hole diameters preferred in the present invention is 0.75 mm to 1.05 mm and at holes centered at ¼″-⅓″, providing minimal fluid accumulation beneath the Temporary Skin Substitute, which will reduce infection complications and maximize wound healing.

    摘要翻译： 提出了一种改进的皮肤替代品，其包括由一系列规则间隔的孔和尼龙网状网制成的非生物材料。 顶部组分是薄（约0.001“厚）的有机硅弹性体，其中孔孔已被真空拉制; 物理上附着于有机硅弹性体的是细针织尼龙织物（12 / 1,15 / 2旦尼尔）; 含有维生素E，维生素C，硫酸软骨素4，硫酸软骨素6和免疫10（高纯度芦荟成分）除了猪胶原肽外，还含有几种伤口愈合剂。 皮肤替代品中的孔提供一系列孔隙度，以确保皮肤替代物下方的最小液体积聚而不伤口干燥。 除了使用胶原肽之外，尼龙网的三维性质提供了与支持新皮肤细胞生长的结构的更好的急性粘附。 在本发明中优选的孔直径的范围是0.75mm至1.05mm，在以“1/3”至1/3“为中心的孔中，在临时皮肤替代物之下提供最小的流体积聚，这将减少感染并发症并最大限度地伤口愈合 。

    Synthetic skin substitutes
    7.
    发明授权
    Synthetic skin substitutes 失效
    合成皮肤替代品

    公开(公告)号：US5196190A

    公开(公告)日：1993-03-23

    申请号：US607128

    申请日：1990-10-03

    申请人： Avinash Nangia ,  Cheung-Tak Hung

    发明人： Avinash Nangia ,  Cheung-Tak Hung

    IPC分类号： A61F13/00 ,  A61L15/22

    CPC分类号： A61F13/00063 ,  A61L15/225 ,  A61L27/60 ,  A61F13/069 ,  A61F2013/00157 ,  A61F2013/00519 ,  A61F2013/00527 ,  A61F2013/0091 ,  A61F2013/00927

    摘要： Membranes suitable for use as wound dressings and in particular as synthetic skin substitutes are disclosed. The membranes consist of a natural or synthetic polymer, a non-gellable polysaccharide and a cross-linking agent.The membranes of the invention may contain one or more additional components selected from water-loss control agents, emulsifying agents and plasticizers. An internal reinforcing material may also be provided to supplement the inherent mechanical strength of the membrane.Methods of forming such membranes are also disclosed.

    摘要翻译： 公开了适用于伤口敷料，特别是合成皮肤替代物的膜。 膜由天然或合成聚合物，不可凝胶多糖和交联剂组成。 本发明的膜可以含有一种或多种选自失水控制剂，乳化剂和增塑剂的其它组分。 还可以提供内部增强材料以补充膜的固有的机械强度。 还公开了形成这种膜的方法。