公开(公告)号：US06974813B2

公开(公告)日：2005-12-13

申请号：US10315369

申请日：2002-12-09

申请人： Ernest S. Hamanaka ,  Angel Guzman-Perez ,  Christian J. Mularski ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Ernest S. Hamanaka ,  Angel Guzman-Perez ,  Christian J. Mularski ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： C07D249/04 ,  A61K31/00 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/425 ,  A61K31/428 ,  A61K31/433 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/475 ,  A61K31/495 ,  A61K31/498 ,  A61K31/502 ,  A61K31/517 ,  A61P3/10 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P19/04 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07D231/14 ,  C07D231/56 ,  C07D249/06 ,  C07D249/10 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D409/00 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D521/00 ,  A61K31/44 ,  C07D215/02 ,  C07D401/00

CPC分类号： C07D231/12 ,  A61K31/428 ,  A61K31/495 ,  C07D231/14 ,  C07D233/56 ,  C07D249/06 ,  C07D249/08 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04

摘要： NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

摘要翻译： NHE-1抑制剂，使用这种NHE-1抑制剂的方法和含有这样的NHE-1抑制剂的药物组合物。 NHE-1抑制剂可用于减少由组织缺血引起的组织损伤。

公开(公告)号：US6147090A

公开(公告)日：2000-11-14

申请号：US391273

申请日：1999-09-07

申请人： Michael P. DeNinno ,  Christian J. Mularski ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  Christian J. Mularski ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  C07D215/22 ,  C07D215/42 ,  C07D215/48 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  C07D215/14 ,  C07D215/38

CPC分类号： C07D401/12 ,  C07D215/42 ,  C07D215/48 ,  C07D417/12

摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

公开(公告)号：US06395751B1

公开(公告)日：2002-05-28

申请号：US09671400

申请日：2000-09-27

申请人： Michael P. DeNinno ,  Christian J. Mularski ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  Christian J. Mularski ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： A61K3147

CPC分类号： C07D401/12 ,  C07D215/42 ,  C07D215/48 ,  C07D417/12

摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

摘要翻译： 胆固醇酯转移蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其他血浆脂质水平的用途，例如LDL-胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

公开(公告)号：US06197786B1

公开(公告)日：2001-03-06

申请号：US09391152

申请日：1999-09-07

申请人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： A61K3147

CPC分类号： C07D409/04 ,  A61K31/47 ,  C07D215/42 ,  C07D215/48 ,  C07D221/16 ,  C07D409/12

摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

摘要翻译： 胆固醇酯转移蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其他血浆脂质水平的用途，例如LDL-胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

公开(公告)号：US6147089A

公开(公告)日：2000-11-14

申请号：US390738

申请日：1999-09-07

申请人： Michael P. DeNinno ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： A61K31/4706 ,  A61K31/473 ,  A61K31/4741 ,  A61K31/4745 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D215/42 ,  C07D215/58 ,  C07D221/10 ,  C07D221/16 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  C07D495/04 ,  C07D513/04 ,  A61K31/47 ,  C07D215/38

CPC分类号： C07D471/04 ,  C07D215/42 ,  C07D221/16 ,  C07D491/04 ,  C07D495/04 ,  Y02P20/55

摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

摘要翻译： 胆固醇酯转移蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其他血浆脂质水平的用途，例如LDL-胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

公开(公告)号：US6140343A

公开(公告)日：2000-10-31

申请号：US391313

申请日：1999-09-07

申请人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： C07D215/16 ,  A61K20060101 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/473 ,  A61K45/00 ,  A61P3/04 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P31/00 ,  C07D20060101 ,  C07D215/00 ,  C07D215/42 ,  C07D215/46 ,  C07D221/06 ,  C07D221/16 ,  C07D413/12 ,  C07D417/12 ,  C07D215/38

CPC分类号： C07D413/12 ,  C07D215/42 ,  C07D215/46 ,  C07D221/16 ,  C07D417/12

摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

公开(公告)号：US06489478B1

公开(公告)日：2002-12-03

申请号：US09671221

申请日：2000-09-27

申请人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： A61K3147

CPC分类号： C07D413/12 ,  C07D215/42 ,  C07D215/46 ,  C07D221/16 ,  C07D417/12

摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

摘要翻译： 胆固醇酯转移蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其他血浆脂质水平的用途，例如LDL-胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

公开(公告)号：US06310075B1

公开(公告)日：2001-10-30

申请号：US09671105

申请日：2000-09-27

申请人： Michael P. DeNinno ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： A61K3147

CPC分类号： C07D471/04 ,  C07D215/42 ,  C07D221/16 ,  C07D491/04 ,  C07D495/04 ,  Y02P20/55

摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

摘要翻译： 胆固醇酯转移蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其他血浆脂质水平的用途，例如LDL-胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

公开(公告)号：US06906082B2

公开(公告)日：2005-06-14

申请号：US10607640

申请日：2003-06-27

申请人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： A61K45/00 ,  A61K31/192 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K45/06 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P35/00 ,  A61P39/02 ,  A61P43/00 ,  C07D20060101 ,  C07D215/00 ,  C07D215/38 ,  C07D215/42 ,  C07D215/48 ,  C07D221/16 ,  C07D409/04 ,  C07D409/12

CPC分类号： C07D409/04 ,  A61K31/47 ,  C07D215/42 ,  C07D215/48 ,  C07D221/16 ,  C07D409/12

摘要： Cholesteryl ster transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

摘要翻译： 胆固醇酯转运蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其它血浆脂质水平的用途，如低密度脂蛋白胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

公开(公告)号：US06586448B1

公开(公告)日：2003-07-01

申请号：US09685380

申请日：2000-10-10

申请人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

发明人： Michael P. DeNinno ,  George T. Magnus-Aryitey ,  Roger B. Ruggeri ,  Ronald T. Wester

IPC分类号： A61K3147

CPC分类号： C07D409/04 ,  A61K31/47 ,  C07D215/42 ,  C07D215/48 ,  C07D221/16 ,  C07D409/12

摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

摘要翻译： 胆固醇酯转移蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其他血浆脂质水平的用途，例如LDL-胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。