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    OPHTHALMIC COMPOSITIONS WITH AN AMPHOTERIC SURFACTANT AND HYALURONIC ACID
    3.
    发明申请
    OPHTHALMIC COMPOSITIONS WITH AN AMPHOTERIC SURFACTANT AND HYALURONIC ACID 有权
    具有AMPHOTERIC表面活性剂和羟丙酸的眼科组合物

    公开(公告)号：US20090196846A1

    公开(公告)日：2009-08-06

    申请号：US12203384

    申请日：2008-09-03

    申请人： Erning Xia ,  Susan E. Burke ,  Srini Venkatesh ,  Vicki Barniak

    发明人： Erning Xia ,  Susan E. Burke ,  Srini Venkatesh ,  Vicki Barniak

    IPC分类号： A01N47/44 ,  A01P1/00

    CPC分类号： C11D3/48 ,  A01N33/12 ,  A01N47/44 ,  A61K9/0048 ,  A61K31/155 ,  A61K31/728 ,  A61K45/06 ,  A61L12/14 ,  A61L12/141 ,  A61L12/142 ,  A61L12/143 ,  C11D1/88 ,  C11D1/92 ,  C11D3/0078 ,  C11D3/227 ,  C11D3/26 ,  Y10S514/912 ,  A01N25/30 ,  A01N2300/00 ,  A61K2300/00

    摘要： Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 0.15 wt. % of hyaluronic acid; and 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

    摘要翻译： 包含0.1ppm至10ppm的选自双胍类，聚合双胍，季铵化合物及其任何混合物的阳离子抗微生物组分的眼用组合物; 0.005重量％ ％〜0.15wt。 ％的透明质酸; 和0.01重量％ ％〜1.0wt ％的通式I的两性表面活性剂，其中R 1是R或 - （CH 2）n -NHC（O）R，其中R是任选被羟基取代的C 8 -C 16烷基，n是2,3或4; R2和R3各自独立地选自甲基，乙基，丙基或异丙​​基; 并且R 4是任选被羟基取代的C 2 -C 8亚烷基。 本发明还直接涉及使用眼用组合物来清洁和消毒隐形眼镜，特别是柔软的硅酮水凝胶隐形眼镜。

    Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
    5.
    发明授权
    Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid 有权
    具有两性表面活性剂和透明质酸的眼科组合物

    公开(公告)号：US08119112B2

    公开(公告)日：2012-02-21

    申请号：US12203384

    申请日：2008-09-03

    申请人： Erning Xia ,  Susan E. Burke ,  Srini Venkatesh ,  Vicki Barniak

    发明人： Erning Xia ,  Susan E. Burke ,  Srini Venkatesh ,  Vicki Barniak

    IPC分类号： A61K31/74

    CPC分类号： C11D3/48 ,  A01N33/12 ,  A01N47/44 ,  A61K9/0048 ,  A61K31/155 ,  A61K31/728 ,  A61K45/06 ,  A61L12/14 ,  A61L12/141 ,  A61L12/142 ,  A61L12/143 ,  C11D1/88 ,  C11D1/92 ,  C11D3/0078 ,  C11D3/227 ,  C11D3/26 ,  Y10S514/912 ,  A01N25/30 ,  A01N2300/00 ,  A61K2300/00

    摘要： Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 0.15 wt. % of hyaluronic acid; and 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

    摘要翻译： 包含0.1ppm至10ppm的选自双胍类，聚合双胍，季铵化合物及其任何混合物的阳离子抗微生物组分的眼用组合物; 0.005重量％ ％〜0.15wt。 ％的透明质酸; 和0.01重量％ ％〜1.0wt ％的通式I的两性表面活性剂，其中R 1是R或 - （CH 2）n -NHC（O）R，其中R是任选被羟基取代的C 8 -C 16烷基，n是2,3或4; R2和R3各自独立地选自甲基，乙基，丙基或异丙​​基; 并且R 4是任选被羟基取代的C 2 -C 8亚烷基。 本发明还直接涉及使用眼用组合物来清洁和消毒隐形眼镜，特别是柔软的硅酮水凝胶隐形眼镜。

    Ophthalmic Compositions with an Amphoteric Surfactant, Hyaluronic Acid and Polyquaternium-1
    8.
    发明申请
    Ophthalmic Compositions with an Amphoteric Surfactant, Hyaluronic Acid and Polyquaternium-1 审中-公开
    具有两性表面活性剂，透明质酸和聚季铵盐的眼用组合物

    公开(公告)号：US20120283333A1

    公开(公告)日：2012-11-08

    申请号：US13553919

    申请日：2012-07-20

    申请人： Erning Xia ,  Susan E. Burke ,  Srini Venkatesh ,  Vicki L. Barniak

    发明人： Erning Xia ,  Susan E. Burke ,  Srini Venkatesh ,  Vicki L. Barniak

    IPC分类号： A01N33/12 ,  A01P1/00 ,  A01N37/52

    CPC分类号： C11D1/92 ,  A01N33/12 ,  A01N47/44 ,  A61K9/0048 ,  A61K31/155 ,  A61K31/728 ,  A61K45/06 ,  A61L12/14 ,  A61L12/141 ,  A61L12/142 ,  A61L12/143 ,  C11D1/88 ,  C11D3/0078 ,  C11D3/26 ,  C11D3/37 ,  C11D3/48 ,  A01N25/30 ,  A01N2300/00 ,  A61K2300/00

    摘要： Ophthalmic compositions that comprise 0.5 ppm to 15 ppm α-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-Ω-tris(2-hydroxyethyl) ammonium chloride; 0.005 wt. % to 0.05 wt. % hyaluronic acid; citrate, citric acid or a mixture thereof; and 0.01 wt. % to 0.8 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n-NHC(O)R, wherein R is a C8-C30alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from the group consisting of hydrogen and C1-C4alkyl; R4 is a C2-C8alkylene optionally substituted with hydroxyl; and Y is CO2− or SO3−. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

    摘要翻译： 包含0.5ppm至15ppm的α-[4-三（2-羟乙基） - 氯化铵-2-丁烯基]聚[1-二甲基氯化铵-2-丁烯基] - 和羟基 - （2-羟乙基） 氯化铵; 0.005重量％ ％〜0.05重量％ ％透明质酸 柠檬酸盐，柠檬酸或其混合物; 和0.01重量％ ％至0.8wt。 ％的通式I的两性表面活性剂，其中R 1是R或 - （CH 2）n -NHC（O）R，其中R是任选被羟基取代的C 8 -C 30烷基，n是2,3或4; R 2和R 3各自独立地选自氢和C 1 -C 4烷基; R4是任选被羟基取代的C 2 -C 8亚烷基; Y是CO 2 - 或SO 3 - 。 本发明还直接涉及使用眼用组合物来清洁和消毒隐形眼镜，特别是柔软的硅酮水凝胶隐形眼镜。