公开(公告)号：US20250032666A1

公开(公告)日：2025-01-30

申请号：US18358109

申请日：2023-07-25

Applicant: Ethicon, Inc.

Inventor： Thomas Weindl ,  Benjamin Fitz ,  Gaojie Hu

IPC: A61L24/08

Abstract: The present invention is directed to hemostatic and/or tissue adhesive formulations comprising crosslinked polysaccharide particles that have been oxidized to generate aldehyde- and carboxylic functional moieties therein, and wherein said formulations further contain a buffer that maintains a slightly alkaline environment. These formulations can be applied onto tissue in the form of a powder, paste or patch to effect hemostasis or sealing.

公开(公告)号：US12168081B2

公开(公告)日：2024-12-17

申请号：US17738636

申请日：2022-05-06

Applicant: Ethicon, Inc.

Inventor： Sai Veruva ,  Salim Ghodbane ,  Thomas Weindl

IPC: A61L24/00 ,  A61L24/04

Abstract: Provided herein are compositions, systems and surgical methods for treating expandable soft tissue utilizing a reactive liquid hydrogel sealant mixture including a cross-linkable electrophilic compound, a nucleophilic compound, and an amphiphilic poly(alkyl)ene glycol block polymer in an amount of 20% (w/v) or less of the sealant composition. The composition can optionally include a viscosifier, in an amount of 0.1% to 1.0% (w/v) of the sealant composition.

公开(公告)号：US20230355831A1

公开(公告)日：2023-11-09

申请号：US17738636

申请日：2022-05-06

Applicant: Ethicon, Inc.

Inventor： Sai Veruva ,  Salim Ghodbane ,  Thomas Weindl

IPC: A61L24/00 ,  A61L24/04

CPC classification number: A61L24/0042 ,  A61L24/0031 ,  A61L24/046 ,  A61L24/0026 ,  A61L24/043

Abstract: Provided herein are compositions, systems and surgical methods for treating expandable soft tissue utilizing a reactive liquid hydrogel sealant mixture including a cross-linkable electrophilic compound, a nucleophilic compound, and an amphiphilic poly(alkyl)ene glycol block polymer in an amount of 20% (w/v) or less of the sealant composition. The composition can optionally include a viscosifier, in an amount of 0.1% to 1.0% (w/v) of the sealant composition.

公开(公告)号：US20220331475A1

公开(公告)日：2022-10-20

申请号：US17667787

申请日：2022-02-09

Applicant: Ethicon, Inc.

Inventor： Nir Nativ ,  Thomas Weindl ,  Benjamin D. Fitz ,  Gerard Llanos ,  Guanghui Zhang ,  Yi-Lan Wang ,  Meng Deng

IPC: A61L15/28 ,  A61L15/42 ,  A61L15/26

Abstract: The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.

公开(公告)号：US20220023488A1

公开(公告)日：2022-01-27

申请号：US16934982

申请日：2020-07-21

Applicant: Ethicon, Inc.

Inventor： Nir Nativ ,  Gerard Llanos ,  Thomas Weindl ,  Sai Veruva

IPC: A61L15/42 ,  A61L15/28 ,  A61L15/32 ,  A61L15/58 ,  A61L15/22

Abstract: The present invention is directed to medical devices having a first porous substrate layer with at least a surface coating thereon of a first co-reactive component and a second substrate layer with at least a surface coating layer of a second co-reactive component that reacts with the first co-reactive component, and a removable barrier layer positioned between the first substrate layer and second substrate layer and in contact with said first substrate layer and said second substrate layer.