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    Methods and devices for co-delivery of liquid and powdered hemostats and sealants
    2.
    发明授权
    Methods and devices for co-delivery of liquid and powdered hemostats and sealants 有权

    公开(公告)号：US10183132B2

    公开(公告)日：2019-01-22

    申请号：US14723796

    申请日：2015-05-28

    Applicant: Ethicon, Inc.

    Inventor： Yi-Lan Wang ,  Leo B. Kriksunov

    IPC: A61M15/00 ,  A61M11/00 ,  A61M5/31 ,  A61M5/315 ,  A61M5/48 ,  A61B17/00

    Abstract: The present invention is directed to an integrated delivery device that is operable with one hand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using such integrated devices.

    Compacted Hemostatic Cellulosic Aggregates
    3.
    发明申请
    Compacted Hemostatic Cellulosic Aggregates 审中-公开

    公开(公告)号：US20170128618A1

    公开(公告)日：2017-05-11

    申请号：US15337337

    申请日：2016-10-28

    Applicant: Ethicon, Inc.

    Inventor： Yi-Lan Wang

    IPC: A61L26/00 ,  D01D5/42

    CPC classification number: A61L26/0023 ,  A61L15/24 ,  A61L26/0061 ,  A61L2400/04 ,  D01D5/426 ,  C08L1/00

    Abstract: The present invention is directed to a hemostatic material comprising a compacted, hemostatic aggregates of cellulosic fibers. In some aspects, the hemostatic material further includes additives, such as carboxymethyl cellulose (CMC) or other polysaccharides, calcium salts, anti-infective agents, hemostasis promoting agents, gelatin, collagen, or combinations thereof. In another aspect, the present invention is directed to a method of making the hemostatic materials described above by compacting a cellulosic-based material into hemostatic aggregates. In another aspect, the present invention is directed to a method of treating a wound by applying hemostatic materials described above onto and/or into the wound of a patient.

    Compacted hemostatic cellulosic aggregates
    6.
    发明授权
    Compacted hemostatic cellulosic aggregates 有权

    公开(公告)号：US10034957B2

    公开(公告)日：2018-07-31

    申请号：US15337337

    申请日：2016-10-28

    Applicant: Ethicon, Inc.

    Inventor： Yi-Lan Wang

    IPC: A61L26/00 ,  D01D5/42

    CPC classification number: A61L15/24 ,  A61L26/0023 ,  A61L26/0061 ,  A61L2400/04 ,  D01D5/426 ,  C08L1/00

    Abstract: The present invention is directed to a hemostatic material comprising a compacted, hemostatic aggregates of cellulosic fibers. In some aspects, the hemostatic material further includes additives, such as carboxymethyl cellulose (CMC) or other polysaccharides, calcium salts, anti-infective agents, hemostasis promoting agents, gelatin, collagen, or combinations thereof. In another aspect, the present invention is directed to a method of making the hemostatic materials described above by compacting a cellulosic-based material into hemostatic aggregates. In another aspect, the present invention is directed to a method of treating a wound by applying hemostatic materials described above onto and/or into the wound of a patient.

    Methods and Devices for Co-Delivery of Liquid and Powdered Hemostats and Sealants
    7.
    发明申请
    Methods and Devices for Co-Delivery of Liquid and Powdered Hemostats and Sealants 审中-公开
    液体和粉状血液和密封胶共同供应的方法和装置

    公开(公告)号：US20160074602A1

    公开(公告)日：2016-03-17

    申请号：US14723796

    申请日：2015-05-28

    Applicant: Ethicon, Inc.

    Inventor： Yi-Lan Wang ,  Leo B. Kriksunov

    IPC: A61M15/00 ,  A61M5/315 ,  A61M5/31 ,  A61M11/00 ,  A61M5/48

    CPC classification number: A61M15/0003 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00522 ,  A61M5/3137 ,  A61M5/31596 ,  A61M5/48 ,  A61M11/007 ,  A61M2005/31598 ,  A61M2202/064

    Abstract: The present invention is directed to an integrated delivery device that is operable with one hand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using such integrated devices.

    Abstract translation: 本发明涉及一体式输送装置，其可以用一只手操作，并且提供液体药剂和粉末药剂到液体药物表达亚单位和粉末药物表达亚单位的组织或伤口上的共同递送。 每个表达亚单位具有用于液体药物的致动器和其中包含的粉末药物，其位于所述表达亚单元的近端处彼此紧邻并且彼此靠近彼此定位的每个所述表达亚单位的递送插管 在所述表达亚基的末端。 本发明还涉及使用这种集成装置的方法。

    EXPANDABLE HEMOSTATIC TABLETS COMPRISING OXIDIZED REGENERATED CELLULOSE
    8.
    发明公开
    EXPANDABLE HEMOSTATIC TABLETS COMPRISING OXIDIZED REGENERATED CELLULOSE 审中-公开

    公开(公告)号：US20240148933A1

    公开(公告)日：2024-05-09

    申请号：US18053628

    申请日：2022-11-08

    Applicant: Ethicon, Inc.

    Inventor： Yi-Lan Wang ,  Tien-Jung Lee

    IPC: A61L15/28

    CPC classification number: A61L15/28 ,  A61L2400/04

    Abstract: The present invention is directed to compressed hemostatic tablets or forms comprising a fibrous non-woven oxidized cellulose (OC or ORC) multilayer material compressed into a form stable tablet, further comprising calcium salt, with the tablets rapidly expandable on contact with blood or blood plasma. The compressed forms may further comprise a multi-arm PEG-SG and are dimensionally, preferably with regard to length and width, stable for at least 48 hours after compression. In some embodiments, the compressed forms will expand upon contact with blood from 1.5 to 5 times of tablet length in 5 seconds; from 2 to 6 times of tablet length in 20 seconds; and from 3 to 6 times of tablet length in 5 minutes. The compressed forms are effective in hemostasis in heparinized blood.

    Multi-Compartment Pre-filled Mixing Syringes with Bypass
    9.
    发明申请
    Multi-Compartment Pre-filled Mixing Syringes with Bypass 审中-公开

    公开(公告)号：US20170319786A1

    公开(公告)日：2017-11-09

    申请号：US15649160

    申请日：2017-07-13

    Applicant: Ethicon, Inc.

    Inventor： Yi-Lan Wang ,  Leo B. Kriksunov

    IPC: A61M5/28 ,  A61M5/315 ,  A61M5/31

    CPC classification number: A61M5/284 ,  A61M5/3129 ,  A61M5/31511

    Abstract: The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.

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