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公开(公告)号:US20140051950A1
公开(公告)日:2014-02-20
申请号:US14062276
申请日:2013-10-24
发明人: Jeffrey W. Clymer , Prasanna Malaviya , Donna L. Korvick , Kevin L. Houser , Cory G. Kimball , Frederick E. Shelton, IV , Chester O. Baxter, III , Taylor W. Aronhalt
CPC分类号: A61B5/4839 , A61B5/14546 , A61B5/486 , A61B5/7282 , A61B5/742 , A61B10/0283 , A61B10/06 , A61B18/1445 , A61B2046/236 , A61B2218/008 , A61M2037/0007
摘要: Biomarkers are collected and used to determine biological propensities of a patient, to determine the efficacy of medical devices, to select and administer therapeutic agents, to select medical devices, to make adjustments to medical devices, and/or to adjust surgical techniques. An apparatus includes a port to draw a biological fluid (e.g., a mist) from a surgical site. The apparatus includes a sensor having a cantilevered beam. The beam includes substances selected to attract certain biomarkers as the fluid is communicated across the beam. The same apparatus or another apparatus is used to administer a therapeutic agent based at least in part on collected biomarker data. The therapeutic agent delivery apparatus may include a device that is also used to create a wound at a surgical site. For instance, a harmonic surgical instrument may be used to both collect biomarkers and administer a therapeutic agent (e.g., gene therapy using sonoporation).
摘要翻译: 生物标志物被收集并用于确定患者的生物倾向性,以确定医疗装置的功效,选择和施用治疗剂,选择医疗装置,调整医疗装置和/或调整手术技术。 一种装置包括从外科手术部位抽取生物流体(例如,雾)的端口。 该装置包括具有悬臂梁的传感器。 梁包括当流体在横梁上连通时选择用于吸引某些生物标志物的物质。 使用相同的装置或另一装置至少部分地基于收集的生物标志物数据来施用治疗剂。 治疗剂递送装置可以包括也用于在手术部位创建伤口的装置。 例如,可以使用谐波手术器械来收集生物标志物并施用治疗剂(例如,使用声波光刻的基因治疗)。
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公开(公告)号:US09456779B2
公开(公告)日:2016-10-04
申请号:US14062276
申请日:2013-10-24
发明人: Jeffrey W. Clymer , Prasanna Malaviya , Donna L. Korvick , Kevin L. Houser , Cory G. Kimball , Frederick E. Shelton, IV , Chester O. Baxter, III , Taylor W. Aronhalt
CPC分类号: A61B5/4839 , A61B5/14546 , A61B5/486 , A61B5/7282 , A61B5/742 , A61B10/0283 , A61B10/06 , A61B18/1445 , A61B2046/236 , A61B2218/008 , A61M2037/0007
摘要: Biomarkers are collected and used to determine biological propensities of a patient, to determine the efficacy of medical devices, to select and administer therapeutic agents, to select medical devices, to make adjustments to medical devices, and/or to adjust surgical techniques. An apparatus includes a port to draw a biological fluid (e.g., a mist) from a surgical site. The apparatus includes a sensor having a cantilevered beam. The beam includes substances selected to attract certain biomarkers as the fluid is communicated across the beam. The same apparatus or another apparatus is used to administer a therapeutic agent based at least in part on collected biomarker data. The therapeutic agent delivery apparatus may include a device that is also used to create a wound at a surgical site. For instance, a harmonic surgical instrument may be used to both collect biomarkers and administer a therapeutic agent (e.g., gene therapy using sonoporation).
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