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    Methods for using canine immunoglobulin variable domains and caninized antibodies
    1.
    发明授权
    Methods for using canine immunoglobulin variable domains and caninized antibodies 失效
    使用犬免疫球蛋白可变结构域和可分化抗体的方法

    公开(公告)号：US07261890B2

    公开(公告)日：2007-08-28

    申请号：US10327598

    申请日：2002-12-20

    申请人： Eugene Regis Krah, III ,  Hongliang Guo ,  Ashok Aiyappa ,  Robert Lawton

    发明人： Eugene Regis Krah, III ,  Hongliang Guo ,  Ashok Aiyappa ,  Robert Lawton

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C12P21/04 ,  C12P21/08

    CPC分类号： C07K16/4291 ,  A61K2039/505 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2319/00

    摘要： The present invention provides canine heavy chain and light chain (both λ and κ) variable domain nucleic acids and polypeptides. The present invention also provides caninized antibodies comprised of the presently disclosed canine variable domain framework sequences and CDRs specific for an antigen obtained from antibodies from other than canines (preferably mouse). The invention also provides methods of making caninized antibodies and using them. This disclosure specifically describes caninized antibodies that are useful in the treatment of canine allergy. The general process of caninization permits the development of useful therapeutics, which includes but is not limited to allergy, osteosarcomma's and lymphomma's.

    摘要翻译： 本发明提供犬重链和轻链（λ和κ）可变结构域核酸和多肽。 本发明还提供了由本发明的犬可变结构域框架序列组成的包含抗体的抗体，以及从犬以外的抗体（优选小鼠）获得的抗原特异性CDR。 本发明还提供了制造可以抗体的抗体并使用它们的方法。 该公开内容具体描述了可用于治疗犬过敏症的耐受性抗体。 罐头化的一般过程允许开发有用的治疗剂，其包括但不限于变态反应，骨肉瘤和淋巴瘤。