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公开(公告)号：US20070185139A1
公开(公告)日：2007-08-09
申请号：US11498221
申请日：2006-08-02
申请人： Eva Binnun , Peter Connolly , Sigmond Johnson , Ronghui Lin , Steven Middleton , Sandra Moreno-Mazza , Niranjan Pandey , Steven Wetter
发明人： Eva Binnun , Peter Connolly , Sigmond Johnson , Ronghui Lin , Steven Middleton , Sandra Moreno-Mazza , Niranjan Pandey , Steven Wetter
IPC分类号： A61K31/519 , C07D498/02
CPC分类号： C07D513/04
摘要： The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof and the thereof as inhibitors of ATP-protein kinase interactions.
摘要翻译： 本发明涉及式（I）的新型噻唑并嘧啶化合物或其形式或组成及其作为ATP-蛋白激酶相互作用的抑制剂。
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公开(公告)号：US20070265264A1
公开(公告)日：2007-11-15
申请号：US11401339
申请日：2006-04-10
申请人： Kathleen Battista , Gilles Bignan , Peter Connolly , Stuart Hayden , Sigmond Johnson , Ronghui Lin , Niranjan Pandey , Mark Powell
发明人： Kathleen Battista , Gilles Bignan , Peter Connolly , Stuart Hayden , Sigmond Johnson , Ronghui Lin , Niranjan Pandey , Mark Powell
IPC分类号： A61K31/505 , A61K31/5377 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/16 , A61P25/28 , A61P31/12 , A61P35/00 , A61P9/10 , C07D239/00 , C07D413/14
CPC分类号： C07D495/16
摘要： The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.
摘要翻译： 本发明涉及式（I）的新型硫代四氮杂苊烯化合物及其药学上可接受的形式，以及它们作为ATP-蛋白激酶相互作用抑制剂的合成和用途。
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公开(公告)号：US20060058341A1
公开(公告)日：2006-03-16
申请号：US11226961
申请日：2005-09-15
IPC分类号： A61K31/4745 , C07D498/02
CPC分类号： C07D497/04 , C07D513/04
摘要： The present invention is directed to novel thiazolopyridines, pharmaceutical compositions thereof, and the use thereof as inhibitors of ATP-protein kinase interactions. The thiazolopyridine compounds have the following Formula (I):
摘要翻译： 本发明涉及新型噻唑并吡啶类，其药物组合物及其作为ATP-蛋白激酶相互作用抑制剂的用途。 噻唑并吡啶化合物具有下式（I）：
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4.发明申请公开(公告)号：US20070225309A1
公开(公告)日：2007-09-27
申请号：US11672177
申请日：2007-02-07
申请人： Peter Connolly , Stuart Emanuel , Stuart Hayden , Sigmond Johnson , Bharat Lagu , Steven Middleton , Niranjan Pandey , Mark Powell
发明人： Peter Connolly , Stuart Emanuel , Stuart Hayden , Sigmond Johnson , Bharat Lagu , Steven Middleton , Niranjan Pandey , Mark Powell
IPC分类号： A61K31/519 , C07D498/14
CPC分类号： C07D495/06
摘要： The present invention is directed to substituted thiatriazaacenaphthylene-6-carbonitrile compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
摘要翻译： 本发明涉及式（I）的取代的四氮杂苊烯-6-腈化合物及其形式，其用于治疗，预防或改善慢性或急性蛋白激酶介导的疾病，病症或病症的合成和用途。
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公开(公告)号：US20110136747A1
公开(公告)日：2011-06-09
申请号：US12789081
申请日：2010-05-27
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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公开(公告)号：US08299017B2
公开(公告)日：2012-10-30
申请号：US12789081
申请日：2010-05-27
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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7.发明申请公开(公告)号：US20090069247A1
公开(公告)日：2009-03-12
申请号：US11869230
申请日：2007-10-09
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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公开(公告)号：US20130102547A1
公开(公告)日：2013-04-25
申请号：US13625293
申请日：2012-09-24
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
IPC分类号： C07K7/06
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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公开(公告)号：US08796203B2
公开(公告)日：2014-08-05
申请号：US13625293
申请日：2012-09-24
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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