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公开(公告)号：US20130102547A1
公开(公告)日：2013-04-25
申请号：US13625293
申请日：2012-09-24
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
IPC分类号： C07K7/06
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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公开(公告)号：US08796203B2
公开(公告)日：2014-08-05
申请号：US13625293
申请日：2012-09-24
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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3.发明申请公开(公告)号：US20090069247A1
公开(公告)日：2009-03-12
申请号：US11869230
申请日：2007-10-09
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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公开(公告)号：US08299017B2
公开(公告)日：2012-10-30
申请号：US12789081
申请日：2010-05-27
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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公开(公告)号：US20110136747A1
公开(公告)日：2011-06-09
申请号：US12789081
申请日：2010-05-27
申请人： Blake Paterson , Amir Tamiz , Niranjan Pandey
发明人： Blake Paterson , Amir Tamiz , Niranjan Pandey
摘要： The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
摘要翻译： 本发明提供了治疗炎症性肠病（例如克罗恩病和溃疡性结肠炎）的材料和方法。 本发明的材料可以包括包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物。 本发明的方法可以包括用包含一种或多种紧密连接拮抗剂和任选的一种或多种治疗剂的组合物治疗有需要的受试者。
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公开(公告)号：US20110077191A1
公开(公告)日：2011-03-31
申请号：US12738815
申请日：2008-10-20
申请人： Amir Tamiz
发明人： Amir Tamiz
CPC分类号： A61K38/06 , A61K9/0053 , A61K9/007 , A61K38/07 , A61K38/08 , A61K45/06 , C07K5/08 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/0823 , C07K5/0825 , C07K5/10 , C07K7/06
摘要： The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides methods for the treatment of excessive or undesirable permeability of a tissue by administering to a subject suffering from such a condition a composition comprising a peptide tight junction antagonist of the invention.
摘要翻译： 本发明提供抑制和/或减少哺乳动物紧密连接的开放的新肽，即肽紧密连接的拮抗剂。 本发明还提供了通过向患有这种病症的受试者施用包含本发明的肽紧密连接拮抗剂的组合物来治疗组织过度或不期望的渗透性的方法。
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公开(公告)号：US08198233B2
公开(公告)日：2012-06-12
申请号：US12670800
申请日：2008-07-28
申请人： Amir Tamiz , Min Lin
发明人： Amir Tamiz , Min Lin
摘要： The present invention provides novel peptides that facilitate the opening of mammalian tight junctions, i.e. tight junction agonists. The present invention also provides methods for the treatment of disease by administering to a subject suffering from the disease a composition comprising a peptide tight junction agonist of the invention in combination with a therapeutically effective amount of an active agent.
摘要翻译： 本发明提供了促进哺乳动物紧密连接的开放的新型肽，即紧密连接的激动剂。 本发明还提供了通过向患有该疾病的受试者施用包含本发明的肽紧密连接激动剂与治疗有效量的活性剂的组合来治疗疾病的方法。
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公开(公告)号：US08957032B2
公开(公告)日：2015-02-17
申请号：US12991658
申请日：2009-05-06
申请人： Sefik Alkan , Amir Tamiz , Kelly Marie Kitchens , Malarvizhi Durai , Neil Poloso , Rosa A. Carrasco
发明人： Sefik Alkan , Amir Tamiz , Kelly Marie Kitchens , Malarvizhi Durai , Neil Poloso , Rosa A. Carrasco
CPC分类号： C07K7/06 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/0821 , C07K5/1008 , C07K5/101
摘要： Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers are identified. Assays for determining modulators of biological barrier permeability and for peptide translocation across biological barriers are provided. Methods for treating diseases relating to aberrant biological barrier permeability and peptide translocation across biological barriers are provided. Such diseases include celiac disease, necrotizing enterocolitis, diabetes, cancer, inflammatory bowel diseases, asthma, COPD, excessive or undesirable immune response, gluten sensitivity, gluten allergy, food allergy, rheumatoid arthritis, multiple sclerosis, immune-mediated or type 1 diabetes mellitus, systemic lupus erythematosus, psoriasis, scleroderma and autoimmune thyroid diseases.
摘要翻译： 鉴定了新型化合物和抑制生物屏障渗透性和抑制跨越生物屏障的肽易位的方法。 提供了用于确定生物屏障渗透性调节剂和穿过生物屏障的肽易位的测定。 提供了治疗与生物屏障渗透性异常有关的疾病和跨越生物屏障的肽易位的方法。 这些疾病包括乳糜泻，坏死性小肠结肠炎，糖尿病，癌症，炎性肠病，哮喘，COPD，过度或不良免疫反应，麸质敏感性，麸质过敏，食物过敏，类风湿性关节炎，多发性硬化，免疫介导或1型糖尿病 ，系统性红斑狼疮，牛皮癣，硬皮病和自身免疫性甲状腺疾病。
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公开(公告)号：US20110275562A1
公开(公告)日：2011-11-10
申请号：US12991658
申请日：2009-05-06
申请人： Sefik Alkan , Amir Tamiz , Kelly Marie Kitchens , Malarvizhi Durai , Neil Poloso , Rosa A. Carrasco
发明人： Sefik Alkan , Amir Tamiz , Kelly Marie Kitchens , Malarvizhi Durai , Neil Poloso , Rosa A. Carrasco
IPC分类号： A61K38/08 , C07K5/09 , C07K5/103 , C07K5/083 , C07K5/097 , A61P3/00 , C07K5/093 , A61K38/06 , A61K38/07 , A61P3/10 , A61P17/00 , C07K7/06 , C07K5/087
CPC分类号： C07K7/06 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/0821 , C07K5/1008 , C07K5/101
摘要： Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers are identified. Assays for determining modulators of biological barrier permeability and for peptide translocation across biological barriers are provided. Methods for treating diseases relating to aberrant biological barrier permeability and peptide translocation across biological barriers are provided. Such diseases include celiac disease, necrotizing enterocolitis, diabetes, cancer, inflammatory bowel diseases, asthma, COPD, excessive or undesirable immune response, gluten sensitivity, gluten allergy, food allergy, rheumatoid arthritis, multiple sclerosis, immune-mediated or type 1 diabetes mellitus, systemic lupus erythematosus, psoriasis, scleroderma and autoimmune thyroid diseases.
摘要翻译： 鉴定了新型化合物和抑制生物屏障渗透性和抑制跨越生物屏障的肽易位的方法。 提供了用于确定生物屏障渗透性调节剂和穿过生物屏障的肽易位的测定。 提供了治疗与生物屏障渗透性异常有关的疾病和跨越生物屏障的肽易位的方法。 这些疾病包括乳糜泻，坏死性小肠结肠炎，糖尿病，癌症，炎性肠病，哮喘，COPD，过度或不良免疫反应，麸质敏感性，麸质过敏，食物过敏，类风湿性关节炎，多发性硬化，免疫介导或1型糖尿病 ，系统性红斑狼疮，牛皮癣，硬皮病和自身免疫性甲状腺疾病。
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公开(公告)号：US08785374B2
公开(公告)日：2014-07-22
申请号：US12738815
申请日：2008-10-20
申请人： Amir Tamiz
发明人： Amir Tamiz
CPC分类号： A61K38/06 , A61K9/0053 , A61K9/007 , A61K38/07 , A61K38/08 , A61K45/06 , C07K5/08 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/0823 , C07K5/0825 , C07K5/10 , C07K7/06
摘要： The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides methods for the treatment of excessive or undesirable permeability of a tissue by administering to a subject suffering from such a condition a composition comprising a peptide tight junction antagonist of the invention.
摘要翻译： 本发明提供抑制和/或减少哺乳动物紧密连接的开放的新肽，即肽紧密连接的拮抗剂。 本发明还提供了通过向患有这种病症的受试者施用包含本发明的肽紧密连接拮抗剂的组合物来治疗组织过度或不期望的渗透性的方法。
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