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公开(公告)号：US10471070B2
公开(公告)日：2019-11-12
申请号：US15529474
申请日：2015-11-25
申请人： Eyal Sheetrit , Izhar Halahmi , Ishay Attar
发明人： Eyal Sheetrit , Izhar Halahmi , Ishay Attar
IPC分类号： A61K31/5575 , A61K9/00 , A61K47/02 , A61K47/34 , A61K31/5377 , A61K47/32
摘要： In some embodiments, the present invention is a composition, including: a bulking agent, where the bulking agent is a kaolin, an absorbent material, where the absorbent material is a fumed silica, a binder, where the binder is an epoxy, and a first active agent, where the first active agent is Latanoprost.
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公开(公告)号：US20170266200A1
公开(公告)日：2017-09-21
申请号：US15529474
申请日：2015-11-25
申请人： Eyal Sheetrit , Izhar Halahmi , Ishay Attar
发明人： Eyal Sheetrit , Izhar Halahmi , Ishay Attar
IPC分类号： A61K31/5575 , A61K9/00 , A61K47/34 , A61K47/32 , A61K31/5377 , A61K47/02
CPC分类号： A61K31/5575 , A61K9/0051 , A61K31/5377 , A61K47/02 , A61K47/32 , A61K47/34 , A61K2300/00
摘要： In some embodiments, the present invention is a composition, including: a bulking agent, where the bulking agent is a kaolin, an absorbent material, where the absorbent material is a fumed silica, a binder, where the binder is an epoxy, and a first active agent, where the first active agent is Latanoprost.
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公开(公告)号：US20200093834A1
公开(公告)日：2020-03-26
申请号：US16531665
申请日：2019-08-05
申请人： Eyal Sheetrit , Izhar Halahmi , Ishay Attar
发明人： Eyal Sheetrit , Izhar Halahmi , Ishay Attar
IPC分类号： A61K31/5575 , A61K9/00 , A61K47/02 , A61K47/34 , A61K31/5377 , A61K47/32
摘要： In some embodiments, the present invention is a composition, including: a bulking agent, where the bulking agent is a kaolin, an absorbent material, where the absorbent material is a fumed silica, a binder, where the binder is an epoxy, and a first active agent, where the first active agent is Latanoprost.
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4.发明申请公开(公告)号：US20100076464A1
公开(公告)日：2010-03-25
申请号：US12563667
申请日：2009-09-21
申请人： Eyal Sheetrit , Israel Nur , Liliana Bar , Lior Weissman
发明人： Eyal Sheetrit , Israel Nur , Liliana Bar , Lior Weissman
CPC分类号： A61L31/143 , A61L31/10 , C08L89/00
摘要： The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.
摘要翻译： 本发明涉及一种用于修复软组织中的开口或缺陷的假体，其制备和使用。 本发明的假体包括内部涂覆有稳定的和非完全干燥的纤维蛋白的底物。 假体显示器在植入后减少了术后并发症。
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5.发明授权公开(公告)号：US08981058B2
公开(公告)日：2015-03-17
申请号：US13847898
申请日：2013-03-20
申请人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
发明人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
摘要翻译： 本发明涉及通过提供交联明胶海绵来制造具有表面的交联明胶海绵的方法，通过施加足量的包含蛋白质或肽活性成分的液体来润湿海绵的表面，其中 足够量的液体即使在干燥后也保持海绵的柔韧性。 然后将海绵干燥成海绵，以获得在其表面上具有蛋白质或肽活性成分层的柔性，干燥且准备使用的交联明胶海绵。
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6.发明申请公开(公告)号：US20110045034A1
公开(公告)日：2011-02-24
申请号：US12920000
申请日：2009-03-02
申请人： Israel Nur , Eyal Sheetrit , Liliana Bar , Guy Tomer
发明人： Israel Nur , Eyal Sheetrit , Liliana Bar , Guy Tomer
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The invention relates to an improved dry cross-linked gelatin sponge comprising a layer of an active ingredient, to methods of its preparation and uses thereof.
摘要翻译： 本发明涉及包含活性成分层的改进的干交联明胶海绵，其制备方法及其用途。
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公开(公告)号：US10039865B2
公开(公告)日：2018-08-07
申请号：US12563667
申请日：2009-09-21
申请人： Eyal Sheetrit , Israel Nur , Liliana Bar , Lior Weissman
发明人： Eyal Sheetrit , Israel Nur , Liliana Bar , Lior Weissman
摘要： The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.
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8.发明申请公开(公告)号：US20140120151A1
公开(公告)日：2014-05-01
申请号：US13847898
申请日：2013-03-20
申请人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
发明人： Israel Nur , Liliana Bar , Guy Tomer , Eyal Sheetrit
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
摘要翻译： 本发明涉及通过提供交联明胶海绵来制造具有表面的交联明胶海绵的方法，通过施加足量的包含蛋白质或肽活性成分的液体来润湿海绵的表面，其中 足够量的液体即使在干燥后也保持海绵的柔韧性。 然后将海绵干燥成海绵，以获得在其表面上具有蛋白质或肽活性成分层的柔性，干燥且准备使用的交联明胶海绵。
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公开(公告)号：US08475812B2
公开(公告)日：2013-07-02
申请号：US12920000
申请日：2009-03-02
申请人： Israel Nur , Eyal Sheetrit , Liliana Bar , Guy Tomer
发明人： Israel Nur , Eyal Sheetrit , Liliana Bar , Guy Tomer
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.
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