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    Gelatin Sponge Comprising an Active Ingredient, Its Preparation and Use
    3.
    发明申请
    Gelatin Sponge Comprising an Active Ingredient, Its Preparation and Use 有权
    明胶海绵包含活性成分，其制备和用途

    公开(公告)号：US20140120151A1

    公开(公告)日：2014-05-01

    申请号：US13847898

    申请日：2013-03-20

    申请人： Israel Nur ,  Liliana Bar ,  Guy Tomer ,  Eyal Sheetrit

    发明人： Israel Nur ,  Liliana Bar ,  Guy Tomer ,  Eyal Sheetrit

    IPC分类号： A61K9/70 ,  A61K38/48

    CPC分类号： A61L15/425 ,  A61K9/70 ,  A61K38/4833 ,  A61L15/32 ,  A61L15/325 ,  A61L15/44 ,  A61L2300/252 ,  A61L2300/418 ,  A61L2300/606 ,  A61L2400/04

    摘要： The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof.

    摘要翻译： 本发明涉及通过提供交联明胶海绵来制造具有表面的交联明胶海绵的方法，通过施加足量的包含蛋白质或肽活性成分的液体来润湿海绵的表面，其中 足够量的液体即使在干燥后也保持海绵的柔韧性。 然后将海绵干燥成海绵，以获得在其表面上具有蛋白质或肽活性成分层的柔性，干燥且准备使用的交联明胶海绵。

    Removal of plasmin or plasminogen from cryoprecipitate
    8.
    发明授权
    Removal of plasmin or plasminogen from cryoprecipitate 有权
    从冷沉淀物中去除纤溶酶或纤溶酶原

    公开(公告)号：US08563288B2

    公开(公告)日：2013-10-22

    申请号：US12289499

    申请日：2008-10-29

    申请人： Israel Nur ,  Liliana Bar ,  Malkit Azachi

    发明人： Israel Nur ,  Liliana Bar ,  Malkit Azachi

    IPC分类号： C12N9/66 ,  A61K35/16

    CPC分类号： C12N9/6435 ,  C07K1/22 ,  C12Y304/21007

    摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.

    摘要翻译： 一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基 氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。

    Device for administering an at least two-component substance
    9.
    发明申请
    Device for administering an at least two-component substance 审中-公开
    用于施用至少两种组分物质的装置

    公开(公告)号：US20100217231A1

    公开(公告)日：2010-08-26

    申请号：US12708453

    申请日：2010-02-18

    申请人： Erez Ilan ,  Moti Meron ,  Kfir Regev ,  Liliana Bar ,  Israel Nur

    发明人： Erez Ilan ,  Moti Meron ,  Kfir Regev ,  Liliana Bar ,  Israel Nur

    IPC分类号： A61M5/31 ,  A61B17/03 ,  A61M35/00

    CPC分类号： A61M5/1582 ,  A61B17/00491 ,  A61B2017/00495 ,  A61M5/3297 ,  A61M2025/0039

    摘要： The device for administering an at least two-component substance comprises a concentric lumen arrangement including (i) an inner cannula having a lumen with an inlet opening at a first end and a tip with an outlet opening at a second end opposite its first end, and (ii) an outer sheath having opposite first and second ends facing the respective first and second ends of the inner cannula, and surrounding the inner cannula along an axial length between the first and second ends of the inner cannula, wherein the outer sheath at its second end is sealingly and fixedly connected to the inner cannula and defining an outer lumen around the inner cannula, and wherein the inner cannula is provided with at least one opening for providing fluid communication between the outer lumen around the inner cannula and the lumen of the inner cannula.

    摘要翻译： 用于施用至少两种组分物质的装置包括同心的腔排列，其包括（i）具有在第一端具有入口开口的内腔和在其第一端相对的第二端处具有出口开口的末端的内套管， 和（ii）外护套，其具有相对的第一和第二端面向所述内套管的相应的第一和第二端，并且沿着所述内套管的第一和第二端之间的轴向长度包围所述内套管，其中， 其第二端密封地和固定地连接到内套管并且围绕内插管限定外腔，并且其中内插管设置有至少一个开口，用于提供围绕内插管的外腔与内套管之间的流体连通 内套管。

    Removal of plasmin(ogen) from protein solutions
    10.
    发明申请
    Removal of plasmin(ogen) from protein solutions 有权
    从蛋白质溶液中去除纤溶酶（ogen）

    公开(公告)号：US20090176293A1

    公开(公告)日：2009-07-09

    申请号：US12289499

    申请日：2008-10-29

    申请人： Israel Nur ,  Liliana Bar ,  Malkit Azachi

    发明人： Israel Nur ,  Liliana Bar ,  Malkit Azachi

    IPC分类号： C12N9/68

    CPC分类号： C12N9/6435 ,  C07K1/22 ,  C12Y304/21007

    摘要： A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms, preferably about 7 Angstroms apart and the rigid amino acid is covalently bound to the support via the amino group of the amino acid.

    摘要翻译： 一种通过使混合物与刚性氨基酸接触的方法，其特征在于从含有纤维蛋白溶酶（ogen）或纤溶酶的混合物中除去或分离纤维蛋白原（纤维蛋白原）存在下的纤维蛋白溶酶或纤溶酶，其中氨基酸和羧基的氨基 氨基酸约6-8埃，优选约7埃，刚性氨基酸通过氨基酸的氨基与载体共价结合。