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公开(公告)号：US20070287721A1
公开(公告)日：2007-12-13
申请号：US11538462
申请日：2006-10-04
申请人： F. Leslie Boyd , Stanley Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Harris , Brian Johns , David Jung , Michael Peel , Jennifer Badiang , Connie Sexton
发明人： F. Leslie Boyd , Stanley Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Harris , Brian Johns , David Jung , Michael Peel , Jennifer Badiang , Connie Sexton
IPC分类号： A61K31/506 , A61K31/437 , A61P31/22 , C07D401/14 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供式（I）化合物：含有该化合物的药物组合物，其制备方法及其作为药剂的用途。
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公开(公告)号：US20050049259A1
公开(公告)日：2005-03-03
申请号：US10433881
申请日：2001-11-26
申请人： F Boyd , Stanley Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Harris , Brian Johns , David Jung , Michael Peel , Jennifer Badiang , Connie Sexton
发明人： F Boyd , Stanley Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Harris , Brian Johns , David Jung , Michael Peel , Jennifer Badiang , Connie Sexton
IPC分类号： A61K31/437 , A61K31/522 , A61P1/00 , A61P1/04 , A61P1/08 , A61P1/14 , A61P1/16 , A61P3/02 , A61P9/10 , A61P11/00 , A61P13/12 , A61P25/00 , A61P25/02 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P29/02 , A61P31/12 , A61P31/22 , A61P35/00 , C07D471/04 , C07D471/02 , A61K31/4745 , A61K31/506
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供式（I）化合物：含有该化合物的药物组合物，其制备方法及其作为药剂的用途。
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3.发明申请Pyrazolopyridines, process for their preparation and use as therapeutic compounds 失效吡唑并吡啶，其制备方法和用作治疗化合物公开(公告)号：US20060058319A1
公开(公告)日：2006-03-16
申请号：US11245972
申请日：2005-10-07
申请人： Michael Alberti , Stanley Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Harris , Brian Johns , David Jung , Michael Peel , Jennifer Stanford
发明人： Michael Alberti , Stanley Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Harris , Brian Johns , David Jung , Michael Peel , Jennifer Stanford
IPC分类号： C07D471/02 , A61K31/506 , A61K31/655 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供式（I）的化合物：
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4.发明申请Pyralopyridines, process for their preparation and use as therapeutic compounds 失效吡咯并吡啶，其制备方法和用作治疗化合物公开(公告)号：US20050059677A1
公开(公告)日：2005-03-17
申请号：US10473196
申请日：2002-03-20
申请人： Michael Alberti , Stanley Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Harris , Brian Johns , David Jung , Michael Peel , Jennifer Stanford
发明人： Michael Alberti , Stanley Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Harris , Brian Johns , David Jung , Michael Peel , Jennifer Stanford
IPC分类号： A61K31/444 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61P31/22 , C07D471/02 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。
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公开(公告)号：US20050171133A1
公开(公告)日：2005-08-04
申请号：US11084410
申请日：2005-03-18
IPC分类号： A61K31/506 , A61P31/12 , A61P31/22 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译： 本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。
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公开(公告)号：US20050182080A1
公开(公告)日：2005-08-18
申请号：US11082466
申请日：2005-03-17
IPC分类号： A61K31/506 , A61P31/12 , A61P31/22 , C07D471/04 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
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公开(公告)号：US20050234083A1
公开(公告)日：2005-10-20
申请号：US10506447
申请日：2003-02-28
申请人： Stanley Chamberlain , Mui Cheung , Holly Emerson , Neil Johnson , Kristen Nailor , Douglas Sammond , Marcus Semones
发明人： Stanley Chamberlain , Mui Cheung , Holly Emerson , Neil Johnson , Kristen Nailor , Douglas Sammond , Marcus Semones
IPC分类号： A61K31/506 , A61K31/5377 , A61K45/00 , A61P9/10 , A61P9/14 , A61P29/00 , A61P35/00 , A61P43/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D43/02
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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公开(公告)号：US20050009845A1
公开(公告)日：2005-01-13
申请号：US10499247
申请日：2002-12-13
申请人： Thomas Caferro , Stanley Chamberlain , Kelly Donaldson , Philip Harris , Michael Gaul , David Uehling , Dana Vanderwall
发明人： Thomas Caferro , Stanley Chamberlain , Kelly Donaldson , Philip Harris , Michael Gaul , David Uehling , Dana Vanderwall
IPC分类号： A61K31/337 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/7072 , A61K45/00 , A61P11/08 , A61P17/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07D495/04 , C07D498/02
CPC分类号： C07D495/04
摘要： The present invention relates to thienopyrmidine compounds of formula (I) (one of A1 and A2 is S and the other is CH), salts thereof, as well as use and preparation of the same. These compounds are inhibitors of various protein tyrosine kinases (PTKs) of the ErbB family and consequently are useful in the treatment of disorders mediated by aberrant activity of such kinases.
摘要翻译： 本发明涉及式（I）的噻吩并嘧啶化合物（A 1和A 2之一是S，另一个是CH），其盐，以及其用途和制备。 这些化合物是ErbB家族的各种蛋白酪氨酸激酶（PTK）的抑制剂，因此可用于治疗由这种激酶的异常活性介导的病症。
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9.发明授权Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections 失效用于治疗病毒感染的鸟苷核苷化合物的氨基磷酸衍生物公开(公告)号：US08759318B2
公开(公告)日：2014-06-24
申请号：US13143098
申请日：2010-01-11
申请人： Stanley Chamberlain , Jeff Hutchins , Karolina Madela , Christopher McGuigan , John Vernachio , Mohamed Aljarah , Arnaud Gilles
发明人： Stanley Chamberlain , Jeff Hutchins , Karolina Madela , Christopher McGuigan , John Vernachio , Mohamed Aljarah , Arnaud Gilles
CPC分类号： C07H19/207 , C07H19/167
摘要： Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.
摘要翻译： 提供了衍生自具有增强的治疗效力的鸟嘌呤碱基的氨基磷酸酯化合物，并且这些化合物在治疗病毒感染方面尤其具有增强的效力，例如丙型肝炎病毒。 还提供了药物组合物，制备化合物的方法，以及使用该化合物和组合物治疗病毒感染的方法。
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公开(公告)号：US20070010540A1
公开(公告)日：2007-01-11
申请号：US11430342
申请日：2006-05-09
申请人： Lisa Shewchuk , Anne Hassell , William Holmes , James Veal , Holly Emerson , David Musso , Stanley Chamberlain , Gregory Peckham
发明人： Lisa Shewchuk , Anne Hassell , William Holmes , James Veal , Holly Emerson , David Musso , Stanley Chamberlain , Gregory Peckham
IPC分类号： A61K31/505 , C07D403/02 , C07D239/48
CPC分类号： C12N9/12 , C07K14/7153 , C07K2299/00 , G06F19/16
摘要： A crystal structure of the cfms kinase domain, co-crystal structure with a bound small molecule, as well as methods of using the same in the discovery of cfms inhibitors and in the treatment of diseases mediated by inappropriate cfms activity.
摘要翻译： 具有结合的小分子的cfms激酶结构域，共晶体结构的晶体结构，以及在发现cfms抑制剂以及治疗不适当cfms活性介导的疾病的方法。
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