公开(公告)号：US20180016555A1

公开(公告)日：2018-01-18

申请号：US15520998

申请日：2015-10-21

Applicant: Five Prime Therapeutics, Inc.

Inventor： Luis Borges ,  Nathan Sallee ,  Charles Kaplan ,  Arthur Brace ,  W. Michael Kavanaugh ,  Brian Wong ,  David Bellovin ,  Thomas Brennan ,  Artur Karasyov

IPC: C12N5/0783 ,  C07K16/28 ,  G01N33/50

CPC classification number: C12N5/0636 ,  C07K16/2803 ,  C07K16/2896 ,  C07K2317/76 ,  C07K2319/30 ,  C12N2501/599 ,  G01N33/505

Abstract: Methods of identifying and using SLAMF1 antagonists are provided.

公开(公告)号：US09169313B2

公开(公告)日：2015-10-27

申请号：US14079742

申请日：2013-11-14

Applicant: Five Prime Therapeutics, Inc.

Inventor： Thomas Harding ,  W. Michael Kavanaugh

IPC: A61K39/00 ,  A61K38/18 ,  C07K14/475 ,  C07K14/50 ,  C07K14/71 ,  A61K38/17

CPC classification number: C07K14/71 ,  A61K38/179 ,  A61K38/1825

Abstract: The present invention relates to the use of Fibroblast Growth Factor Receptor I (FGFR1) extracellular domain (ECD) polypeptides for treatment of cancers characterized by ligand dependent activating mutations in Fibroblast Growth Factor Receptor 2 (FGFR2). For example, the present invention relates to the treatment of endometrial cancers and other cancers wherein tumor cells express FGFR2 mutants in the IgII-IgIII hinge region or IgIII domain of the protein, such as at amino acid positions 252 and/or 253.

Abstract translation: 本发明涉及成纤维细胞生长因子受体I（FGFR1）细胞外结构域（EGFR）多肽用于治疗以成纤维细胞生长因子受体2（FGFR2）中配体依赖性激活突变为特征的癌症的用途。 例如，本发明涉及治疗子宫内膜癌和其它癌症，其中肿瘤细胞在蛋白质的IgII-IgIII铰链区或IgIII结构域中表达FGFR2突变体，例如在氨基酸位置252和/或253。

公开(公告)号：US20140274898A1

公开(公告)日：2014-09-18

申请号：US14185086

申请日：2014-02-20

Applicant: FIVE PRIME THERAPEUTICS, INC.

Inventor： Thomas Brennan ,  Robert Dean ,  W. Michael Kavanaugh ,  Janine Powers

IPC: C07K14/71 ,  A61K31/506 ,  A61K31/473 ,  A61K38/17

CPC classification number: C07K14/71 ,  A61K8/64 ,  A61K31/473 ,  A61K31/506 ,  A61K38/179 ,  A61Q7/00

Abstract: The present invention relates to a method of promoting hair growth comprising administering a fibroblast growth factor receptor 3 (FGFR3) extracellular domain (ECD), including native FGFR3 ECDs, variants, fragments, and fusion molecules, to a subject in an amount sufficient to promote hair growth.

Abstract translation: 促进毛发生长的方法本发明涉及一种促进毛发生长的方法，包括以足以促进毛发生长的量施用包含天然FGFR3 ECDs，变体，片段和融合分子的成纤维细胞生长因子受体3（FGFR3）细胞外结构域（ECD） 头发生长。