公开(公告)号：US20220213089A1

公开(公告)日：2022-07-07

申请号：US17439646

申请日：2020-03-13

申请人： FORMA Therapeutics, Inc.

发明人： Shawn E.R. SCHILLER ,  Torsten HERBERTZ ,  Hongbin LI ,  Bradford GRAVES ,  Steven MISCHKE ,  Angela V. WEST ,  Anna ERICSSON ,  Jennifer R. DOWNING

IPC分类号： C07D471/04

摘要： The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.

公开(公告)号：US20210214323A1

公开(公告)日：2021-07-15

申请号：US17187061

申请日：2021-02-26

申请人： FORMA Therapeutics, Inc.

发明人： Kenneth W. Bair ,  David R. Lancia, JR. ,  Hongbin LI ,  James Loch ,  Wei Lu ,  Matthew W. Martin ,  David S. Millan ,  Shawn E.R. Schiller ,  Mark J. Tebbe

IPC分类号： C07D295/192 ,  A61K45/06 ,  C07D215/14 ,  C07D231/56 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D257/04 ,  C07D487/04 ,  C07D263/57 ,  C07D491/048 ,  C07D271/12 ,  C07D495/04 ,  C07D209/18 ,  C07D277/62 ,  C07D277/66 ,  C07D513/04 ,  C07D213/56 ,  C07D305/08 ,  A61K31/4965 ,  A61P35/00 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  C07D209/08 ,  C07D213/65 ,  C07D213/69 ,  C07D217/16 ,  C07D231/12 ,  C07D235/08 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

摘要： The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US20200017458A1

公开(公告)日：2020-01-16

申请号：US16566119

申请日：2019-09-10

申请人： FORMA Therapeutics, Inc.

发明人： Kenneth W. Bair ,  David R. Lancia, JR. ,  Hongbin LI ,  James Loch ,  Wei Lu ,  Matthew W. Martin ,  David S. Millan ,  Shawn E.R. Schiller ,  Mark J. Tebbe

IPC分类号： C07D295/192 ,  C07D417/04 ,  C07D403/04 ,  C07D401/04 ,  C07D235/08 ,  C07D231/12 ,  C07D217/16 ,  C07D213/69 ,  C07D213/65 ,  C07D209/08 ,  A61K31/506 ,  A61K31/5025 ,  A61K31/4985 ,  A61K31/497 ,  A61K31/496 ,  A61K31/495 ,  A61K31/4965 ,  C07D305/08 ,  C07D213/56 ,  C07D513/04 ,  C07D277/66 ,  C07D277/62 ,  C07D209/18 ,  C07D495/04 ,  C07D271/12 ,  C07D491/048 ,  C07D263/57 ,  C07D487/04 ,  C07D257/04 ,  C07D471/04 ,  C07D417/12 ,  C07D413/12 ,  C07D405/12 ,  C07D231/56 ,  C07D215/14 ,  A61K45/06

摘要： The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below: