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公开(公告)号：US20240150349A1
公开(公告)日：2024-05-09
申请号：US18463587
申请日：2023-09-08
Applicant: FORMA Therapeutics, Inc.
Inventor： Shawn E.R. Schiller , Torsten Herbertz , Hongbin Li , Bradford Graves , Steven Mischke , Angela V. West , Jennifer R. Downing , Anna Ericsson
IPC: C07D471/04 , A61P35/00 , C07D519/00
CPC classification number: C07D471/04 , A61P35/00 , C07D519/00
Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
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公开(公告)号：US20200216445A1
公开(公告)日：2020-07-09
申请号：US16647478
申请日：2018-09-14
Applicant: FORMA Therapeutics, Inc.
Inventor： Shawn E.R. Schiller , Torsten Herbertz , Hongbin Li , Bradford Graves , Steven Mischke , Angela V. West , Jennifer R. Downing , Anna Ericsson
IPC: C07D471/04 , C07D519/00 , A61P35/00
Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
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公开(公告)号：US20200017525A1
公开(公告)日：2020-01-16
申请号：US16077407
申请日：2017-02-13
Applicant: FORMA Therapeutics, Inc.
Inventor： David Joseph Guerin , Kenneth W. Bair , Justin A. Caravella , Stephanos Ioannidis, Jr. , David R. Lancia, Jr. , Hongbin Li , Steven Mischke , Pui Yee Ng , David Richard , Shawn E.R. Schiller , Tatiana Shelekhin , Zhongguo Wang
IPC: C07D519/00 , C07D495/04
Abstract: The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, R6, R7, X, m, and n are described herein.
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公开(公告)号：US20180370933A1
公开(公告)日：2018-12-27
申请号：US16119962
申请日：2018-08-31
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, JR. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , C07D305/08 , A61K31/495 , C07D401/04 , C07D277/66 , C07D277/62 , C07D271/12 , C07D263/57 , C07D257/04 , C07D235/08 , C07D231/56 , C07D231/12 , C07D217/16 , C07D215/14 , C07D213/69 , C07D213/65 , C07D213/56 , C07D209/18 , C07D209/08 , A61K45/06 , A61K31/506 , A61K31/5025 , C07D513/04 , C07D495/04 , C07D491/048 , C07D487/04 , C07D471/04 , C07D417/12 , C07D417/04 , C07D413/12 , C07D405/12 , C07D403/04 , A61K31/4985 , A61K31/497 , A61K31/496 , A61K31/4965
CPC classification number: C07D295/192 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D209/08 , C07D209/18 , C07D213/56 , C07D213/65 , C07D213/69 , C07D215/14 , C07D217/16 , C07D231/12 , C07D231/56 , C07D235/08 , C07D257/04 , C07D263/57 , C07D271/12 , C07D277/62 , C07D277/66 , C07D305/08 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D513/04 , A61K2300/00
Abstract: The present invention relates to compounds and compositions for inhibition of FASN, their synthesis, applications, and antidotes.
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公开(公告)号：US20180050997A1
公开(公告)日：2018-02-22
申请号：US15786539
申请日：2017-10-17
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, JR. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , C07D213/65 , A61K31/4965 , C07D231/12 , C07D235/08 , C07D401/04 , C07D403/04 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , C07D209/08 , C07D417/04 , C07D213/69 , C07D305/08 , C07D213/56 , C07D513/04 , C07D277/66 , C07D277/62 , C07D209/18 , C07D495/04 , C07D271/12 , C07D491/048 , C07D263/57 , C07D487/04 , C07D257/04 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/12 , C07D231/56 , C07D215/14 , C07D217/16 , A61K45/06
Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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Patent Agency Ranking
公开(公告)号：US20230061891A1
公开(公告)日：2023-03-02
申请号：US17383610
申请日：2021-07-23
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Adam C. Talbot
IPC: C07D401/04 , C07D401/14 , A61K31/4709 , A61K45/06 , A61K31/47 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D405/14 , C07D413/14 , C07D215/20 , C07D215/48 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D473/28 , C07D487/04 , A61K31/517 , A61K31/519 , A61K31/496 , A61K31/501 , A61K31/52 , C07D401/12 , C07D405/04 , C07D417/10
Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
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公开(公告)号：US20190241533A1
公开(公告)日：2019-08-08
申请号：US16389286
申请日：2019-04-19
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, JR. , Hongbin Li , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , C07D213/65 , A61K31/4965 , C07D231/12 , C07D235/08 , C07D401/04 , C07D403/04 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , C07D209/08 , C07D417/04 , C07D213/69 , C07D305/08 , C07D213/56 , C07D513/04 , C07D277/66 , C07D277/62 , C07D209/18 , C07D495/04 , C07D271/12 , C07D491/048 , C07D263/57 , C07D487/04 , C07D257/04 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/12 , C07D231/56 , C07D215/14 , A61K45/06 , C07D217/16
Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US20190127347A1
公开(公告)日：2019-05-02
申请号：US16225484
申请日：2018-12-19
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Adam C. Talbot
IPC: C07D401/04 , C07D487/04 , A61K45/06 , A61K31/52 , C07D401/12 , C07D405/04 , A61K31/496 , A61K31/501 , C07D417/14 , C07D417/04 , C07D413/04 , C07D409/14 , C07D215/48 , C07D215/20 , C07D413/14 , C07D405/14 , C07D473/28 , C07D471/04 , A61K31/519 , A61K31/517 , A61K31/4709 , C07D401/14 , A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/47 , C07D417/10
Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
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公开(公告)号：US20180312524A1
公开(公告)日：2018-11-01
申请号：US16029166
申请日：2018-07-06
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Adam C. Talbot , Mark J. Tebbe
IPC: C07D498/04 , C07D413/14 , C07D409/12 , C07D241/50 , A61K31/541 , C07D403/10 , A61K31/517 , A61K31/55 , C07D417/06 , C07D401/14 , C07D417/10 , C07D405/14 , C07D401/12 , C07D487/04 , C07D413/12 , A61K31/553 , C07D487/08 , C07D491/048 , C07D417/04 , C07D413/04 , C07D401/10 , A61K31/519 , C07D409/06 , A61K31/506 , A61K31/5025 , A61K31/53 , C07D471/04 , C07D403/06 , C07D417/14 , A61K31/4985 , C07D413/06 , A61K31/551 , C07D451/04 , A61K31/498 , C07D405/10 , C07D401/04 , C07D241/42 , A61K31/5377 , C07D409/14 , C07D403/04 , C07D403/14 , C07D401/06 , C07D405/12 , C07D403/12 , C07D405/06 , A61K45/06 , C07D495/04 , C07D405/04
CPC classification number: C07D498/04 , A61K31/498 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D241/42 , C07D241/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D495/04 , A61K2300/00
Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.
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公开(公告)号：US20180215766A1
公开(公告)日：2018-08-02
申请号：US15937271
申请日：2018-03-27
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , Torsten Herbertz , Goss S. Kauffman , Katherine J. Kayser-Bricker , George P. Luke , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Adam C. Talbot
IPC: C07D487/04 , C07D417/10 , A61K31/52 , A61K45/06 , A61K31/47 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D401/14 , A61K31/4709 , A61K31/517 , A61K31/519 , C07D401/12 , C07D405/04 , A61K31/496 , A61K31/501 , C07D417/14 , C07D417/04 , C07D413/04 , C07D409/14 , C07D401/04 , C07D215/48 , C07D215/20 , C07D413/14 , C07D405/14 , C07D473/28 , C07D471/04
CPC classification number: C07D401/04 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D215/20 , C07D215/48 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D473/28 , C07D487/04 , A61K2300/00
Abstract: The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.
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