专利检索 ap:("FORMA Therapeutics, Inc.") AND inv:"Shawn E.R. SCHILLER" 第 1 页

1.

发明申请
TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS 有权
标题翻译：四氢喹啉组合物作为BROMODOMAIN抑制剂

公开(公告)号：US20150232445A1

公开(公告)日：2015-08-20

申请号：US14546775

申请日：2014-11-18

申请人： Forma Therapeutics, Inc.

发明人： Kenneth W. BAIR , Torsten HERBERTZ , Goss S. KAUFFMAN , Katherine J. KAYSER-BRICKER , George P. LUKE , Matthew W. MARTIN , David S. MILLAN , Shawn E.R. SCHILLER , Adam C. TALBOT

IPC分类号： C07D401/04 , A61K31/5377 , A61K45/06 , A61K31/517 , C07D487/04 , A61K31/519 , A61K31/4709 , C07D401/14

CPC分类号： C07D487/04 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D215/20 , C07D215/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D473/28 , A61K2300/00

摘要： The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula I: wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.

摘要翻译： 本发明涉及可用于治疗癌症，炎性疾病，糖尿病和肥胖症的溴和额外末端（BET）溴结构域的抑制剂，其具有式I：其中W，X，Y，Z，R 1，R 2，R 5 ，和R8如本文所述。

2.

发明申请
BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS 有权
标题翻译：苯并吡嗪组合物作为BROMODOMAIN抑制剂

公开(公告)号：US20150232465A1

公开(公告)日：2015-08-20

申请号：US14546896

申请日：2014-11-18

申请人： Forma Therapeutics, Inc.

发明人： Kenneth W. BAIR , Torsten HERBERTZ , Goss S. KAUFFMAN , Katherine J. KAYSER-BRICKER , George P. LUKE , Matthew W. MARTIN , David S. MILLAN , Shawn E.R. SCHILLER , Adam C. TALBOT , Mark J. TEBBE

IPC分类号： C07D471/04 , A61K31/498 , C07D405/14 , C07D417/14 , C07D417/10 , C07D241/42 , C07D409/14 , C07D405/06 , C07D413/14 , C07D413/04 , C07D401/04 , C07D403/14 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D403/04

CPC分类号： C07D498/04 , A61K31/498 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D241/42 , C07D241/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/048 , C07D495/04 , A61K2300/00

摘要： The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.

摘要翻译： 本发明涉及具有式（I）的可用于治疗癌症，炎性疾病，糖尿病和肥胖症的溴和额外末端（BET）溴结构域抑制剂：其中X，Y，Z，R 1，R 2，R 4 和R7在本文中定义。

3.

发明申请
INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) 有权

公开(公告)号：US20220213089A1

公开(公告)日：2022-07-07

申请号：US17439646

申请日：2020-03-13

申请人： FORMA Therapeutics, Inc.

发明人： Shawn E.R. SCHILLER , Torsten HERBERTZ , Hongbin LI , Bradford GRAVES , Steven MISCHKE , Angela V. WEST , Anna ERICSSON , Jennifer R. DOWNING

IPC分类号： C07D471/04

摘要： The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.