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1.发明授权Polymers containing multivalent amyloid-beta-binding D-peptides and their use 有权含多价淀粉样蛋白-β结合D-肽的聚合物及其用途公开(公告)号：US09464118B2
公开(公告)日：2016-10-11
申请号：US14388869
申请日：2013-04-05
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have amyloid-beta-binding properties, and to the use of these substances, referred to hereinbelow as “polymers”, in particular in medicine.
摘要翻译： 本发明涉及由本身已经具有淀粉样蛋白-β结合性质的几种相互连接的物质组成的新型多价聚合淀粉样蛋白-β结合物质，以及这些物质（以下称为“聚合物”），特别是在医学中的用途 。
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2.发明申请POLYMERS CONTAINING MULTIVALENT AMYLOID-BETA-BINDING D-PEPTIDES AND THEIR USE 有权含多元羧甲基-β-结合型D肽的聚合物及其用途公开(公告)号：US20150119336A1
公开(公告)日：2015-04-30
申请号：US14388869
申请日：2013-04-05
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have amyloid-beta-binding properties, and to the use of these substances, referred to hereinbelow as “polymers”, in particular in medicine.
摘要翻译： 本发明涉及由本身已经具有淀粉样蛋白-β结合性质的几种相互连接的物质组成的新型多价聚合淀粉样蛋白-β结合物质，以及这些物质（以下称为“聚合物”），特别是在医学中的用途 。
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公开(公告)号：US10746747B2
公开(公告)日：2020-08-18
申请号：US14902760
申请日：2014-06-25
IPC分类号： G01N33/68 , G01N33/543
摘要： A method for the quantitative characterization of substances with regard to their properties of binding to amyloid-β (Aβ) conformers, comprising the steps of: —fractionating a sample including various Aβ conformers; —immobilizing a biotinylated Aβ conformer of the desired fraction on the surface of a substrate having high affinity for biotin; and —deriving the binding behavior of an aggregate quality control probe to the desired Aβ conformer from the measurement signal by determining the kinetic and/or thermodynamic parameters. A device for carrying out the method.
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公开(公告)号：US10889618B2
公开(公告)日：2021-01-12
申请号：US16200820
申请日：2018-11-27
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik , Antonia Nicole Klein
摘要： The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.
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公开(公告)号：US10167318B2
公开(公告)日：2019-01-01
申请号：US15482968
申请日：2017-04-10
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik , Antonia Nicole Klein
摘要： The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.
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公开(公告)号：US20190085030A1
公开(公告)日：2019-03-21
申请号：US16200820
申请日：2018-11-27
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik , Antonia Nicole Klein
摘要： The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.
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公开(公告)号：US10088487B2
公开(公告)日：2018-10-02
申请号：US14902754
申请日：2014-06-25
摘要： A method for the quantitative characterization of amyloid and/or aggregated peptides and/or proteins in a sample, comprising:—providing a sample, wherein the sample includes an amyloid and/or aggregated peptide and/or protein having at least one aggregate size and shape;—adding an active ingredient to be analyzed to the sample solution;—separating the amyloid and/or aggregated peptides and/or proteins are from one another according to their aggregate size and shape;—optionally completely denaturing the amyloid and/or aggregated peptides and/or proteins of a particular fraction into monomer building blocks;—determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by comparison against control values without the active ingredient.
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