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公开(公告)号：US10948499B2
公开(公告)日：2021-03-16
申请号：US15548266
申请日：2016-02-25
IPC分类号： G01N33/68 , G01N33/96 , G01N33/543
摘要： An inorganic nanoparticle is provided (step A) having the size of the aggregate of the protein misfolding disease. Free amino groups or free carboxyl groups are formed (step B) on the surface of the nanoparticle (for functionalizing the nanoparticle surface into an amine- or carboxy-functionalized nanoparticle. Maleinimido spacer carboxylic acid is bound to the free amino groups in step (B). Or, free carboxyl groups in step (B) are converted into NHS esters. Monomers of the protein aggregate are bound i) to the maleinimido spacer carboxylic acids by way of a sulfhydryl group at the free end of the monomers, or ii) to the NHS esters by way of the amino group at the free end of the monomer. A standard is provided for use in the detection of protein aggregates occurring with protein misfolding diseases.
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公开(公告)号：US09591845B2
公开(公告)日：2017-03-14
申请号：US14388865
申请日：2013-04-05
发明人： Dieter Willbold
CPC分类号： A01N1/0278 , A01N1/0226 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/4711 , G01N2333/4709
摘要： The invention relates to the treatment of blood, blood products and organs for the removal and/or detoxification of amyloid-beta oligomers.
摘要翻译： 本发明涉及血液，血液制品和器官的治疗以去除和/或解毒淀粉样蛋白-β低聚物。
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3.发明授权Polymers containing multivalent amyloid-beta-binding D-peptides and their use 有权含多价淀粉样蛋白-β结合D-肽的聚合物及其用途公开(公告)号：US09464118B2
公开(公告)日：2016-10-11
申请号：US14388869
申请日：2013-04-05
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have amyloid-beta-binding properties, and to the use of these substances, referred to hereinbelow as “polymers”, in particular in medicine.
摘要翻译： 本发明涉及由本身已经具有淀粉样蛋白-β结合性质的几种相互连接的物质组成的新型多价聚合淀粉样蛋白-β结合物质，以及这些物质（以下称为“聚合物”），特别是在医学中的用途 。
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4.发明申请POLYMERS CONTAINING MULTIVALENT AMYLOID-BETA-BINDING D-PEPTIDES AND THEIR USE 有权含多元羧甲基-β-结合型D肽的聚合物及其用途公开(公告)号：US20150119336A1
公开(公告)日：2015-04-30
申请号：US14388869
申请日：2013-04-05
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik
CPC分类号： C07K14/4711 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have amyloid-beta-binding properties, and to the use of these substances, referred to hereinbelow as “polymers”, in particular in medicine.
摘要翻译： 本发明涉及由本身已经具有淀粉样蛋白-β结合性质的几种相互连接的物质组成的新型多价聚合淀粉样蛋白-β结合物质，以及这些物质（以下称为“聚合物”），特别是在医学中的用途 。
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公开(公告)号：US11224632B2
公开(公告)日：2022-01-18
申请号：US16470616
申请日：2017-12-21
发明人： Dieter Willbold , Dagmar Juergens , Janine Kutzsche , Gustavo Adolfo Guzman Castro , Patricia Hidalgo Jimenez
IPC分类号： A61K38/10 , A61K38/12 , C07K7/00 , C07K7/08 , C07K7/50 , C07K9/00 , C07K11/00 , A61K9/00 , A61K38/17 , A61P25/04 , A61P25/02 , A61P25/00 , A61P25/06 , A61P25/28 , C07K11/02 , C07K7/64
摘要： The present invention relates to a composition consisting of or containing peptides selected from the group consisting of or containing RD2, D3, homologs having at least 50% identity and derivatives of RD2 or D3 and also polymers containing or consisting of RD2/D3 homologs having at least 50% identity and derivatives of RD2 and under D3 for use as an analgesic, for use in pain therapy, for use in the treatment of chronic and/or neuropathic pain and/or for inhibiting N-type neuronal calcium channels (NCCs).
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公开(公告)号：US11175288B2
公开(公告)日：2021-11-16
申请号：US14900361
申请日：2014-06-25
发明人： Dieter Willbold , Susanne Aileen Funke , Eva Birkmann , Kateryna Kravchenko , Oliver Bannach , Carsten Korth , Verian Bader , Steffen Huebinger
IPC分类号： G01N33/68 , C07K14/47 , G01N33/543 , G01N21/64 , G01N33/564
摘要： The invention concerns a method for detecting indicators for determining diseases (disease indicators), in which aggregates of misfolded proteins play a role, and a method for selective quantitation and/or characterization of these disease indicators.
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公开(公告)号：US10239923B2
公开(公告)日：2019-03-26
申请号：US15559078
申请日：2016-03-01
摘要： Peptides specifically binding amyloid beta and to methods of treating and diagnosing Alzheimer's dementia using such peptides are provided.
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8.发明授权Peptides for the treatment and early diagnosis of Alzheimer's disease and other tauopathies 有权用于治疗和早期诊断阿尔茨海默病和其他tau蛋白病的肽公开(公告)号：US09580469B2
公开(公告)日：2017-02-28
申请号：US14432802
申请日：2013-09-10
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/4711 , G01N33/6896 , G01N2800/2821
摘要： The present invention relates to novel tau protein aggregate-binding peptides, homologs, fragments, parts and polymers thereof and to the use thereof.
摘要翻译： 本发明涉及新型tau蛋白聚集体结合肽，其同系物，片段，部分和聚合物及其用途。
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公开(公告)号：US20200319208A1
公开(公告)日：2020-10-08
申请号：US16758048
申请日：2018-10-25
发明人： Christian Zafiu , Dieter Willbold , Bettina Kass
IPC分类号： G01N33/68 , G01N33/543
摘要： Provided herein is a method for quantifying protein aggregates of a protein misfolding disease in a sample, comprising: placing a capture molecule A on a substrate; selecting a complex sample comprising an aggregate of the protein misfolding disease; removing insoluble components from the sample; contacting the sample with capture molecule A on a part of the substrate; contacting a calibration standard with the capture molecule A on another part of the substrate, contacting at least one capture molecule B with both the aggregate of the sample and the calibration standard, wherein the capture molecule B can emit a detectable signal; comparing the signals of the at least one capture molecule B arranged on the sample assembly and on the calibration standard, wherein the steps do not have to be carried out successively. A related device, kit, and method for detecting protein aggregates are also provided.
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公开(公告)号：US20190085030A1
公开(公告)日：2019-03-21
申请号：US16200820
申请日：2018-11-27
发明人： Dieter Willbold , Susanne Aileen Funke , Oleksander Brener , Luitgard Nagel-Steger , Dirk Bartnik , Antonia Nicole Klein
摘要： The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.
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