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公开(公告)号：US20190381104A1
公开(公告)日：2019-12-19
申请号：US16445053
申请日：2019-06-18
申请人： FRED HUTCHINSON CANCER RESEARCH CENTER , SEATLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE
发明人： Colleen Delaney , Michael Jensen , Rebecca Gardner
IPC分类号： A61K35/28 , A61K35/17 , C07K14/73 , C07K14/705 , C07K16/00
摘要： Hematopoietic stem/progenitor cells (HSPC) and/or non-T effector cells are genetically modified to express (i) an extracellular component including a ligand binding domain that binds a cellular marker preferentially expressed on an unwanted cell; and (ii) an intracellular component comprising an effector domain. Among other uses, the modified cells can be administered to patients to target unwanted cancer cells without the need for immunological matching before administration.
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2.发明申请公开(公告)号：US20180142212A1
公开(公告)日：2018-05-24
申请号：US15804555
申请日：2017-11-06
申请人： Fred Hutchinson Cancer Research Center , NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA THE GENOMICS INSTITUTE OF THE NOVARTIS
IPC分类号： C12N5/0789 , A61K35/28
CPC分类号： C12N5/0647 , A61K35/28 , A61K2035/124 , C12N2501/125 , C12N2501/145 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/38 , C12N2501/42 , C12N2501/60 , C12N2501/999
摘要： The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. Also provided herein are methods for expanding the hematopoietic stem/progenitor cells using kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. The hematopoietic stem/progenitor cells expanded using the disclosed kits, compositions and methods include human umbilical cord blood stem/progenitor cells, placental cord blood stem/progenitor cells and peripheral blood stem cells. The present invention also relates to administering hematopoietic stem/progenitor cells expanded using a combination of a Notch agonist and an aryl hydrocarbon receptor antagonist to a patient for short-term and/or long-term in vivo repopulation benefits.
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公开(公告)号：US20180355318A1
公开(公告)日：2018-12-13
申请号：US15570191
申请日：2016-04-29
IPC分类号： C12N5/0789 , C12N5/0783 , A61K35/28 , G01N33/569 , C12N15/86 , C07K14/725 , C07K14/705 , C07K16/28 , C07K14/715
CPC分类号： C12N5/0647 , A61K35/28 , A61K39/0011 , A61K2039/5156 , C07K14/7051 , C07K14/70521 , C07K14/7153 , C07K16/2803 , C07K2319/02 , C12N5/0646 , C12N15/86 , C12N2501/105 , C12N2501/113 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2305 , C12N2501/2306 , C12N2501/2307 , C12N2501/2311 , C12N2501/26 , C12N2501/42 , C12N2501/599 , C12N2510/00 , C12N2740/15043 , C12N2740/16043 , C12N2740/16045 , C12N2810/6081 , G01N33/56966
摘要： Hematopoeitic stem/progenitor cells (HSPC) and/or non-T effector cells are modified to express an extracellular component including a tag cassette. The tag cassette can be used to activate, promote proliferation of, detect, enrich, isolate, track, deplete and/or eliminate modified cells. The cells can also be modified to express a binding domain.
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公开(公告)号：US09834755B2
公开(公告)日：2017-12-05
申请号：US14363748
申请日：2012-12-07
IPC分类号： A61K35/28 , C12N5/0789 , A61K35/12
CPC分类号： C12N5/0647 , A61K35/28 , A61K2035/124 , C12N2501/125 , C12N2501/145 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/38 , C12N2501/42 , C12N2501/60 , C12N2501/999
摘要： The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. Also provided herein are methods for expanding the hematopoietic stem/progenitor cells using kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. The hematopoietic stem/progenitor cells expanded using the disclosed kits, compositions and methods include human umbilical cord blood stem/progenitor cells, placental cord blood stem/progenitor cells and peripheral blood stem cells. The present invention also relates to administering hematopoietic stem/progenitor cells expanded using a combination of a Notch agonist and an aryl hydrocarbon receptor antagonist to a patient for short-term and/or long-term in vivo repopulation benefits.
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公开(公告)号：US20190298778A1
公开(公告)日：2019-10-03
申请号：US16378229
申请日：2019-04-08
IPC分类号： A61K35/51 , C12N5/0789 , A61K35/50
摘要： The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
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公开(公告)号：US20180142210A1
公开(公告)日：2018-05-24
申请号：US15570209
申请日：2016-04-29
IPC分类号： C12N5/0789 , C12N15/85
CPC分类号： C12N5/0647 , C07K2317/524 , C07K2317/526 , C12N15/85 , C12N15/86 , C12N2510/00 , C12N2740/16043 , C12N2740/16045 , C12N2810/6081
摘要： Stem cells are modified to express an extracellular component including a tag cassette. The tag cassette can be used to detect, enrich, isolate, activate, track, deplete, or eliminate modified cells. The cells can be administered before or following differentiation into a more committed cell type.
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公开(公告)号：US20200030384A1
公开(公告)日：2020-01-30
申请号：US16590255
申请日：2019-10-01
IPC分类号： A61K35/51 , C12N5/0789 , A61K35/28 , A61K35/50 , G16B30/00
摘要： The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the HLA antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/progenitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
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公开(公告)号：US20200009194A1
公开(公告)日：2020-01-09
申请号：US16480481
申请日：2018-01-24
发明人： Colleen Delaney
IPC分类号： A61K35/28 , C12N5/0789
摘要： Systems and methods to expand hematopoietic stem cell (HSC) using zwitterionic hydrogels (ZTG) are described. Expansion using the disclosed systems and methods results in HSC populations with (i) an increased proportion of HSC versus partially or fully differentiated cells, (ii) proportionally lower cell surface expression levels of differentiation/maturation markers, (iii) reduced metabolic rates following expansion, and/or (iv) a greater proportion of quiescent cells following expansion, as compared to currently available clinical expansion methods.
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公开(公告)号：US20190298777A1
公开(公告)日：2019-10-03
申请号：US16378206
申请日：2019-04-08
IPC分类号： A61K35/51 , C12N5/0789 , A61K35/50
摘要： The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
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公开(公告)号：US20160199418A1
公开(公告)日：2016-07-14
申请号：US14801771
申请日：2015-07-16
IPC分类号： A61K35/51
CPC分类号： A61K35/51 , A61K35/28 , A61K35/50 , C12N5/0647 , C12N2500/90 , C12N2501/125 , C12N2501/145 , C12N2501/23 , C12N2501/26 , C12N2501/42 , C12N2501/58 , G16B30/00 , Y02A50/411
摘要： The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the HLA antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/progenitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
摘要翻译： 本发明涉及通过选择用于给予患者的扩张的人脐带血干细胞/祖细胞样品库来提供造血功能的方法和组合物，其中所述池中的样品集体不匹配 患者在患者中输入的HLA抗原或等位基因中超过2个; 并将所选择的扩增的人脐带血干细胞/祖细胞样本池投放到患者体内。 本文还提供了获得扩展的人脐带血干细胞/祖细胞样品池，膨胀的人脐带血干细胞/祖细胞样品的冷库的库的方法和用于生产这种库的方法。
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