公开(公告)号：US20160365231A1

公开(公告)日：2016-12-15

申请号：US14905912

申请日：2014-07-04

Applicant: FUDAN UNIVERSITY

Inventor： Fuxing XU ,  Liang WANG ,  Chuanfan DING

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/0081 ,  H01J49/0031 ,  H01J49/0063 ,  H01J49/427

Abstract: This invention is related to a tandem mass spectrometric analysis method in ion trap mass analyzer. Such method comprise three stages as represented by selective isolation, collision induced disassociation and mass scanning of ion. At the collision induced isolation stage, this invention is expected to endow parent ion of certain mass-charge ratio with energy through resonance excitation by changing cycle of radio frequency signals, namely frequency of radio frequency voltage imposed on the ion trap; such high-energy ions produced through resonance excitation are to be disassociated through collision with neutral molecules in the ion trap, which will further generate product ion to realize tandem mass spectrometric analysis. Advantage of this method lies in the fact that it can realize collision induced disassociation by changing scanning cycle at the stage of collision induced disassociation stage through software configuration, which can significantly simplify experimental devices and methods for tandem mass spectrometric analysis.

Abstract translation: 本发明涉及离子阱质量分析仪中的串联质谱分析方法。 这种方法包括由选择性分离，碰撞诱导的离解和离子的质量扫描所表示的三个阶段。 在碰撞诱导的隔离阶段，本发明预期通过改变射频信号的周期，即施加在离子阱上的射频电压的频率，通过共振激发赋予具有一定质量荷电比的母体离子; 通过共振激发产生的这种高能离子将通过与离子阱中的中性分子的碰撞而解离，这将进一步产生产物离子以实现串联质谱分析。 该方法的优点在于它可以通过软件配置在碰撞诱导解离阶段改变扫描周期来实现碰撞引发的分离，这可以显着简化串联质谱分析的实验装置和方法。

公开(公告)号：US20190013194A1

公开(公告)日：2019-01-10

申请号：US15556109

申请日：2015-11-23

Applicant: FUDAN UNIVERSITY

Inventor： Qiankun DANG ,  Xiaodong XIE ,  Fuxing XU ,  Yinjuan CHEN ,  Chuanfan DING

IPC: H01J49/42 ,  H01J49/16 ,  H01J49/06

Abstract: The present invention relates to the technical field of mass analysis instruments. Disclosed is an ion excitation method in a linear ion trap. The method comprises: in a linear ion trap, and at an ion collision-induced dissociation stage, simultaneously applying an auxiliary excitation signal in radial X and Y directions thereof; increasing the kinetic energy of ions in the two directions, thereby increasing collisions with a center gas to cause dissociation; and converting the kinetic energy to internal energy to achieve tandem mass spectrometry analysis. The kinetic energy in the X and Y directions of the ion is increased, and compared to a conventional dissociation method in which ions are primarily excited in one direction, more kinetic energy is converted to internal energy, thus improving dissociation efficiency, shortening reaction time, and addressing a low mass cutoff effect in the ion trap.

公开(公告)号：US20160049287A1

公开(公告)日：2016-02-18

申请号：US14829454

申请日：2015-08-18

Applicant: FUDAN UNIVERSITY

Inventor： Chuanfan DING ,  Li DING

IPC: H01J49/42 ,  H01J49/06

CPC classification number: H01J49/4225 ,  H01J49/004 ,  H01J49/065 ,  H01J49/4235

Abstract: The invention “Ion Trap Array (ITA)” pertains generally to the field of ion storage and analysis technologies, and particularly to the ion storing apparatus and mass spectrometry instruments which separate ions by its character such as mass-to-charge ratio. The aim of this invention is providing an apparatus for ion storage and analysis comprising at least two or more rows of parallel placed electrode array wherein each electrode array includes at least two or more parallel bar-shaped electrodes, by applying different phase of alternating current voltages on different bar electrodes to create alternating electric fields inside the space between two parallel electrodes of different rows of electrode arrays, multiple linear ion trapping fields paralleled constructed in the space between the different rows of electrode arrays which are open to adjacent each other without a real barrier. This invention also provides a method for ion storage and analysis involving with the trapping, cooling and mass-selected analyzing of ions by this apparatus mentioned which constructs multiple conjoint linear ion trapping fields in the space between the different rows of electrode arrays

Abstract translation: 本发明“离子阱阵列（ITA）”一般涉及离子存储和分析技术领域，特别涉及离子存储装置和质谱仪器，它们通过诸如质荷比的特性分离离子。 本发明的目的是提供一种用于离子存储和分析的装置，其包括至少两行或多行平行放置的电极阵列，其中每个电极阵列包括至少两个或更多个平行的棒状电极，通过施加不同相位的交流电压 在不同的棒电极上在不同行电极阵列的两个平行电极之间的空间内部产生交替电场，多个线性离子俘获场平行地构造在电极阵列的不同行之间的空间中，这些空间彼此相邻而没有实际 屏障。 本发明还提供一种离子存储和分析的方法，其涉及通过所述装置进行的捕获，冷却和质量选择的离子分析，其构造了在不同行电极阵列之间的空间中的多个联合线性离子捕获场