公开(公告)号：US20190013194A1

公开(公告)日：2019-01-10

申请号：US15556109

申请日：2015-11-23

Applicant: FUDAN UNIVERSITY

Inventor： Qiankun DANG ,  Xiaodong XIE ,  Fuxing XU ,  Yinjuan CHEN ,  Chuanfan DING

IPC: H01J49/42 ,  H01J49/16 ,  H01J49/06

Abstract: The present invention relates to the technical field of mass analysis instruments. Disclosed is an ion excitation method in a linear ion trap. The method comprises: in a linear ion trap, and at an ion collision-induced dissociation stage, simultaneously applying an auxiliary excitation signal in radial X and Y directions thereof; increasing the kinetic energy of ions in the two directions, thereby increasing collisions with a center gas to cause dissociation; and converting the kinetic energy to internal energy to achieve tandem mass spectrometry analysis. The kinetic energy in the X and Y directions of the ion is increased, and compared to a conventional dissociation method in which ions are primarily excited in one direction, more kinetic energy is converted to internal energy, thus improving dissociation efficiency, shortening reaction time, and addressing a low mass cutoff effect in the ion trap.

公开(公告)号：US20160365231A1

公开(公告)日：2016-12-15

申请号：US14905912

申请日：2014-07-04

Applicant: FUDAN UNIVERSITY

Inventor： Fuxing XU ,  Liang WANG ,  Chuanfan DING

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/0081 ,  H01J49/0031 ,  H01J49/0063 ,  H01J49/427

Abstract: This invention is related to a tandem mass spectrometric analysis method in ion trap mass analyzer. Such method comprise three stages as represented by selective isolation, collision induced disassociation and mass scanning of ion. At the collision induced isolation stage, this invention is expected to endow parent ion of certain mass-charge ratio with energy through resonance excitation by changing cycle of radio frequency signals, namely frequency of radio frequency voltage imposed on the ion trap; such high-energy ions produced through resonance excitation are to be disassociated through collision with neutral molecules in the ion trap, which will further generate product ion to realize tandem mass spectrometric analysis. Advantage of this method lies in the fact that it can realize collision induced disassociation by changing scanning cycle at the stage of collision induced disassociation stage through software configuration, which can significantly simplify experimental devices and methods for tandem mass spectrometric analysis.

Abstract translation: 本发明涉及离子阱质量分析仪中的串联质谱分析方法。 这种方法包括由选择性分离，碰撞诱导的离解和离子的质量扫描所表示的三个阶段。 在碰撞诱导的隔离阶段，本发明预期通过改变射频信号的周期，即施加在离子阱上的射频电压的频率，通过共振激发赋予具有一定质量荷电比的母体离子; 通过共振激发产生的这种高能离子将通过与离子阱中的中性分子的碰撞而解离，这将进一步产生产物离子以实现串联质谱分析。 该方法的优点在于它可以通过软件配置在碰撞诱导解离阶段改变扫描周期来实现碰撞引发的分离，这可以显着简化串联质谱分析的实验装置和方法。