公开(公告)号：US09640377B2

公开(公告)日：2017-05-02

申请号：US14905912

申请日：2014-07-04

申请人： FUDAN UNIVERSITY

发明人： Fuxing Xu ,  Liang Wang ,  Chuanfan Ding

IPC分类号： H01J49/00 ,  H01J49/42

CPC分类号： H01J49/0081 ,  H01J49/0031 ,  H01J49/0063 ,  H01J49/427

摘要： This invention is related to a tandem mass spectrometric analysis method in ion trap mass analyzer. Such method comprise three stages as represented by selective isolation, collision induced disassociation and mass scanning of ion. At the collision induced isolation stage, this invention is expected to endow parent ion of certain mass-charge ratio with energy through resonance excitation by changing cycle of radio frequency signals, namely frequency of radio frequency voltage imposed on the ion trap; such high-energy ions produced through resonance excitation are to be disassociated through collision with neutral molecules in the ion trap, which will further generate product ion to realize tandem mass spectrometric analysis. Advantage of this method lies in the fact that it can realize collision induced disassociation by changing scanning cycle at the stage of collision induced disassociation stage through software configuration, which can significantly simplify experimental devices and methods for tandem mass spectrometric analysis.

公开(公告)号：US20130299693A1

公开(公告)日：2013-11-14

申请号：US13877580

申请日：2011-10-13

申请人： Yu Xia ,  Frank A. Londry

发明人： Yu Xia ,  Frank A. Londry

IPC分类号： H01J49/00

CPC分类号： H01J49/004 ,  H01J49/0031 ,  H01J49/0063 ,  H01J49/428

摘要： A tandem mass spectrometer system and method are described, where a composite voltage waveform is applied to so as to trap ion having selected m/z. The trapped ions may be subject to collision induced ionization dissociation (CID) by a selectable discrete frequency voltage waveform positioned so as to be in a notch in a broadband waveform. The resultant ion products may be trapped using a second notch having a center frequency corresponding to the ion product to be trapped. The process may be repeated so as to increase the amount of ions produced, or the process a first resultant ion product to yield a second resultant in product, which may be trapped.

摘要翻译： 描述了串联质谱仪系统和方法，其中施加复合电压波形以捕获具有选定m / z的离子。 被捕获的离子可能通过可选的离散频率电压波形进行碰撞感应电离解离（CID），该波形定位成宽带波形中的陷波。 可以使用具有对应于待捕获的离子产物的中心频率的第二缺口来捕获所得的离子产物。 可以重复该过程，以便增加产生的离子的量，或者加工第一合成的离子产物以产生可能被捕获的第二产物。

公开(公告)号：US08309914B2

公开(公告)日：2012-11-13

申请号：US12359526

申请日：2009-01-26

申请人： Mircea Guna ,  Yves Le Blanc ,  Bruce Collings

发明人： Mircea Guna ,  Yves Le Blanc ,  Bruce Collings

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/426 ,  H01J49/0063 ,  H01J49/24

摘要： Methods for fragmenting ions in an ion trap are described. These methods involve a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10−4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; e) providing a non-steady-state pressure increase of at least 10% of the operating pressure within the ion trap by delivering a neutral gas into the ion trap for at least a portion of the retention time interval to raise the pressure in the ion trap to a varying first elevated-pressure in the range between about 6×10−5 Torr to about 5×10−4 Torr for a first elevated-pressure duration; and f) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. The excitation time interval and the first elevated-pressure duration substantially overlap in time.

摘要翻译： 描述了在离子阱中分离离子的方法。 这些方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10-4乇的工作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; e）通过将中性气体输送到离子阱中至少保留时间间隔的一部分来提供至少10％的离子阱内的工作压力的非稳态压力增加，以提高离子中的压力 在第一升高压力持续时间内，在约6×10 -5 Torr至约5×10 -4 Torr之间的范围内捕获变化的第一升高压力; 和f）在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低到小于兴奋水平的保持水平以保留碎片 的离子阱内的母离子。 激发时间间隔和第一升高压力时间基本上在时间上重叠。

公开(公告)号：US20110127424A1

公开(公告)日：2011-06-02

申请号：US12955499

申请日：2010-11-29

申请人： Andreas Brekenfeld

发明人： Andreas Brekenfeld

IPC分类号： H01J49/00

CPC分类号： H01J49/42 ,  H01J49/005 ,  H01J49/0063

摘要： In an RF ion trap, analyte ions are fragmented by applying a moderately high RF storage voltage to the trap. The ions are then excited via dipolar excitation, and after a short time, the ions are forced into a resting state, again using dipolar excitation. The RF storage voltage is then rapidly reduced to a low value thereby making it possible to store small fragment ions produced by ergodic decompositions that occur subsequent to the reduction of the RF storage voltage.

摘要翻译： 在RF离子阱中，通过对陷阱施加适度高的RF存储电压来分析离子。 然后通过偶极激发激发离子，并且在短时间之后，离子被强制进入静止状态，再次使用偶极激发。 然后将RF存储电压迅速降低到低的值，从而使得可以存储由于在RF存储电压的降低之后发生的遍历分解产生的小碎片离子。

公开(公告)号：US20070295903A1

公开(公告)日：2007-12-27

申请号：US11662693

申请日：2005-09-12

申请人： Jae Schwartz

发明人： Jae Schwartz

IPC分类号： H01J49/42

CPC分类号： H01J49/42 ,  H01J49/0063

摘要： Rapid and efficient fragmentation of ions in an ion trap for MS/MS analysis is achieved by a pulsed fragmentation technique. Ions of interest are placed at an elevated value of Q and subjected to a relatively high amplitude, short-duration resonance excitation pulse to cause the ions to undergo collision-induced fragmentation. The Q value of the ions of interest is then reduced before significant numbers of ion fragments are expelled from the ion trap, thereby decreasing the low-mass cutoff and allowing retention and subsequent measurement of lower-mass ion fragments.

摘要翻译： 通过脉冲碎裂技术实现MS / MS分析的离子阱中离子的快速高效分裂。 将感兴趣的离子放置在Q的升高值上，并经受相对较高的振幅，短时间的共振激励脉冲，导致离子发生碰撞引起的分裂。 然后，在从离子阱中排出大量离子片段之前，所关心的离子的Q值降低，从而降低低质量截留值，并允许保留并随后测量低质量离子片段。

公开(公告)号：US20070181803A1

公开(公告)日：2007-08-09

申请号：US11653859

申请日：2007-01-17

申请人： Hideki Hasegawa ,  Yuichiro Hashimoto ,  Izumi Waki

发明人： Hideki Hasegawa ,  Yuichiro Hashimoto ,  Izumi Waki

IPC分类号： B01D59/44

CPC分类号： H01J49/4225 ,  H01J49/0063

摘要： In a mass spectrometer in which a high ion dissociation efficiency is possible, inserted electrodes are arranged with a form divided into two or more in the axial direction of the ion trap, an electric static harmonic potential is formed from a DC voltage applied to the inserted electrodes, and with an Supplemental AC voltage applied, ions in the ion trap are oscillated between the divided inserted electrodes in the axial direction of the ion trap by resonance excitation, and the ion with a mass/charge ratio within a specific range is mass-selectively dissociated. Thus, a high ion dissociation efficiency is realized by the use of ion trap of the present invention.

摘要翻译： 在能够实现高离子解离效率的质谱仪中，插入电极以离子阱的轴向分割成两个以上的形式配置，从施加到插入的DC电压形成电静电谐波电位 电极，并且通过施加补充AC电压，离子阱中的离子通过共振激发在离子阱的轴向方向上在分离的插入电极之间振荡，并且质量/电荷比在特定范围内的离子是质量 - 选择性离解。 因此，通过使用本发明的离子阱来实现高离子解离效率。

公开(公告)号：US07064323B2

公开(公告)日：2006-06-20

申请号：US10495044

申请日：2003-06-27

申请人： Hideo Yamakoshi ,  Hiroshi Futami ,  Minoru Danno ,  Shigenori Tsuruga ,  Shizuma Kuribayashi

发明人： Hideo Yamakoshi ,  Hiroshi Futami ,  Minoru Danno ,  Shigenori Tsuruga ,  Shizuma Kuribayashi

IPC分类号： H01J49/00 ,  B01D59/44 ,  C12M1/34

CPC分类号： H01J49/162 ,  F23J2215/301 ,  H01J49/0063 ,  H01J49/424 ,  H01J49/428

摘要： A vacuum ultraviolet lamp ionizes a chemical substance contained in exhaust gas Gs. The chemical substance ionized is trapped in an ion trapping apparatus in which a radio frequency electric field is formed. Energy is applied to an ion group in the ion trapping apparatus with a SWIFT waveform comprising a frequency component excluding a frequency corresponding to an orbital resonance frequency of ions of the chemical substance to remove an impurity. Energy is then applied to the ion group with a TICKLE waveform having a frequency component corresponding to the orbital resonance frequency of the ions of the chemical substance to fragmentate the ions of the chemical substance. A mass of the fragment is then measured with a mass spectrometer to identify the chemical substance.

摘要翻译： 真空紫外灯照射废气Gs中含有的化学物质。 电离的化学物质被捕获在形成射频电场的离子俘获装置中。 能量被施加到离子俘获装置中的离子组，其SWIFT波形包括除了与化学物质的离子的轨道共振频率相对应的频率的频率分量以除去杂质。 然后用具有对应于化学物质的离子的轨道共振频率的频率分量的TICKLE波形将能量施加到离子组，以使化学物质的离子破碎。 然后用质谱仪测量该片段的质量以鉴定化学物质。

公开(公告)号：US07064317B2

公开(公告)日：2006-06-20

申请号：US10485807

申请日：2002-08-12

申请人： Scott A. McLuckey ,  Gavin E. Reid ,  James Mitchell Wells

发明人： Scott A. McLuckey ,  Gavin E. Reid ,  James Mitchell Wells

IPC分类号： H01J49/00

CPC分类号： H01J49/424 ,  H01J49/0063 ,  H01J49/0072 ,  H01J49/0077 ,  H01J49/04 ,  H01J49/42

摘要： A method of inhibiting the reaction between ions of opposite polarity is disclosed. The method includes exposing a population of ions to a resonance excitation frequency during a mass-to-charge altering reaction between a first subpopulation of ions and a second subpopulation of ions, the resonance excitation frequency being tuned to inhibit the mass-to-charge altering reaction between an ion of the first subpopulation of ions having a predetermined mass-to-charge ratio and an ion of the second subpopulation of ions so that when an ion of the first subpopulation of ions attains the predetermined mass-to-charge ratio, the ion having the predetermined mass-to-charge ratio is selectively inhibited from reacting with ions of the second subpopulation of ions.

公开(公告)号：US06949743B1

公开(公告)日：2005-09-27

申请号：US10941653

申请日：2004-09-14

申请人： Jae C. Schwartz

发明人： Jae C. Schwartz

IPC分类号： H01J49/42

CPC分类号： H01J49/42 ,  H01J49/0063

摘要： Rapid and efficient fragmentation of ions in an ion trap for MS/MS analysis is achieved by a pulsed fragmentation technique. Ions of interest are placed at an elevated value of Q and subjected to a relatively high amplitude, short-duration resonance excitation pulse to cause the ions to undergo collision-induced fragmentation. The Q value of the ions of interest is then reduced before significant numbers of ion fragments are expelled from the ion trap, thereby decreasing the low-mass cutoff and allowing retention and subsequent measurement of lower-mass ion fragments.

摘要翻译： 通过脉冲碎裂技术实现MS / MS分析的离子阱中离子的快速高效分裂。 将感兴趣的离子放置在Q的升高值上，并经受相对较高的振幅，短时间的共振激励脉冲，导致离子发生碰撞引起的分裂。 然后，在从离子阱中排出大量离子片段之前，所关心的离子的Q值降低，从而降低低质量截留值，并允许保留并随后测量低质量离子片段。

公开(公告)号：US20030189168A1

公开(公告)日：2003-10-09

申请号：US10310000

申请日：2002-12-04

发明人： Frank Londry ,  Bruce A. Collings ,  William R. Stott

IPC分类号： H01J049/42

CPC分类号： H01J49/4225 ,  H01J49/0063 ,  H01J49/421

摘要： In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution. The technique includes trapping the ions in an ion trap, preferably a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10null5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1V(0nullpk). The technique allows selective dissociation of ions with a discrimination of at least about 1 m/z at a practical fragmentation efficiencies. Apparatus and related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectrums at relatively high resolutions using the low pressure fragmentation technique.

摘要翻译： 在质谱领域中，以分辨率较高的方式分离离子的方法和装置。 该技术包括将离子俘获在离子阱中，优选线性离子阱，其中背景或中性气体压力优选在10 -5 Torr量级。 被俘获的离子在相对较低的激发水平（例如小于1V（0-pk））下相对延长的时间段（例如超过50ms）被共振激发。 该技术允许在实际的分裂效率下以至少约1m / z的区别选择性离解离子。 还公开了使用低压碎裂技术以相对高分辨率获得MS，MS 2，MS 3和MS n谱的装置和相关方法。