公开(公告)号：US20200276428A1

公开(公告)日：2020-09-03

申请号：US16801116

申请日：2020-02-25

申请人： FUJIFILM Corporation

发明人： Ikuo TAKANO

IPC分类号： A61M37/00 ,  B29C39/42

摘要： Provided is a manufacturing method of a microneedle array capable of closing a needle-like recessed portion with a drug solution and providing a high yield.A manufacturing method of a microneedle array includes: an adjustment step of positioning and adjusting a mold having a first surface and a second surface, which oppose each other, and a plurality of needle-like recessed portions in the first surface, and an ejection nozzle which ejects a drug solution in a first direction; a relative movement step of moving the mold and the ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the ejection nozzle to coincide with each other in a plan view in the first direction; an ejection step of ejecting the drug solution from the ejection nozzle toward the needle-like recessed portion; a vibration step of vibrating the mold to move the drug solution toward the needle-like recessed portion and close the needle-like recessed portion with the drug solution after the ejection step; and a suction step of suctioning the second surface of the mold.

公开(公告)号：US20150008211A1

公开(公告)日：2015-01-08

申请号：US14497616

申请日：2014-09-26

申请人： FUJIFILM Corporation

发明人： Ikuo TAKANO ,  Toru TSUCHIHASHI ,  Tomokazu SEKI

IPC分类号： G03F7/32 ,  G03F7/00

CPC分类号： G03F7/32 ,  G03F7/0002 ,  G03F7/0017 ,  G03F7/039 ,  G03F7/325 ,  G11B5/82 ,  H01L21/0337

摘要： A method for developing a non chemically amplified resist employs a developing fluid having a carboxylic acid compound, which is a carboxylic acid ester having branched chain alkyl groups and a total carbon number of 8 or greater, as a main component. It is particularly preferable for the carboxylic acid compound to be at least one of isobutyl butyrate, butyl isobutyrate, isobutyl isobutyrate, isoamyl isobutyrate, and 2-methylbutyrate 2-methylbutyl. It is also preferable for the non chemically amplified resist to be a resist having a copolymer of an α-chloroacrylate ester compound and an α-methylstyrene compound as a main component.

摘要翻译： 用于开发非化学放大抗蚀剂的方法采用具有羧酸化合物的显影液，其是具有支链烷基和总碳数为8以上的羧酸酯作为主要成分。 特别优选羧酸化合物为丁酸异丁酯，异丁酸丁酯，异丁酸异丁酯，异丁酸异戊酯和2-甲基丁酸2-甲基丁酯中的至少一种。 非化学放大型抗蚀剂也优选为具有α-氯代丙烯酸酯化合物和α-甲基苯乙烯化合物的共聚物作为主要成分的抗蚀剂。

公开(公告)号：US20190351204A1

公开(公告)日：2019-11-21

申请号：US16391338

申请日：2019-04-23

申请人： FUJIFILM Corporation

发明人： Yoshiki SAKAZAKI ,  Ikuo TAKANO ,  Satoshi WAKAMATSU ,  Keio OKANO ,  Kenichiro TAMAKI

IPC分类号： A61M37/00 ,  B29C39/10 ,  B29C39/42 ,  B29C39/44

摘要： Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

公开(公告)号：US20180243952A1

公开(公告)日：2018-08-30

申请号：US15901891

申请日：2018-02-22

申请人： FUJIFILM Corporation

发明人： Keio OKANO ,  Yoshinobu KATAGIRI ,  Satoshi WAKAMATSU ,  Ikuo TAKANO

IPC分类号： B29C41/22 ,  B29C41/42 ,  B29C41/38 ,  A61M37/00

CPC分类号： B29C41/22 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C41/38 ,  B29C41/42 ,  B29K2105/0035 ,  B29K2105/0073 ,  B29K2883/00 ,  B29L2031/753

摘要： Provided is a manufacturing method of a sheet having needle-like protrusions capable of individually manufacturing sheets on a mold. The manufacturing method of a sheet having needle-like protrusions includes, for a mold provided with needle-like recesses and an annular groove provided around a region where the needle-like recesses are formed, a first polymer solution supplying step of supplying a first polymer solution, which is to become a first layer, to the needle-like recesses; a second polymer solution supplying step of filling the needle-like recesses and the groove with a second polymer solution by supplying the second polymer solution, which is to become a second layer, to a surface of the mold; a drying step of forming a laminate of the first layer and the second layer by drying the first polymer solution and the second polymer solution; and a peeling step of peeling the laminate away from the mold.

公开(公告)号：US20180028459A1

公开(公告)日：2018-02-01

申请号：US15650981

申请日：2017-07-17

申请人： FUJIFILM Corporation

发明人： Takashi URABE ,  Ikuo TAKANO

IPC分类号： A61K9/70 ,  B29C39/02 ,  A61M37/00

CPC分类号： A61K9/703 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C39/021 ,  B29K2995/0056 ,  B29L2031/753

摘要： A method of producing a transdermal absorption sheet includes a preparatory step of forming the sheet portion in advance by drying and solidifying a base solution in a thin film state, a drug solution arrangement step of arranging a drug solution on a surface of a mold having needle-like recessed portions, a drug solution filling step of filling the needle-like recessed portions with the drug solution while pressingly expanding the drug solution on the surface of the mold by pressing the drug solution on the surface of the mold to the surface of the mold with the sheet portion, a drying step of drying an undried drug solution filling the needle-like recessed portions with the sheet portion to form needle-like protruding portions on a lower surface of the sheet portion, and a peeling-off step of peeling off the sheet portion and the needle-like protruding portions from the mold.

公开(公告)号：US20210001103A1

公开(公告)日：2021-01-07

申请号：US17026335

申请日：2020-09-21

申请人： FUJIFILM Corporation

发明人： Ikuo TAKANO

IPC分类号： A61M37/00

摘要： Provided is a method for manufacturing a microneedle array in which the distal end of a needle-like recessed portion is reliably filled with a drug solution. The problem is solved by a method for manufacturing a microneedle array, including: a positioning adjustment step of adjusting positioning of a mold having a needle-like recessed portion on a front surface, and a drug solution ejection nozzle which ejects a drug solution; a relative movement step of moving the mold and the drug solution ejection nozzle relative to each other to cause a position of the needle-like recessed portion and a position of the drug solution ejection nozzle to coincide with each other in a plan view in a direction parallel to an ejection direction of the drug solution; an ejection step of ejecting the drug solution from the drug solution ejection nozzle toward the needle-like recessed portion; and a suction step of suctioning a rear surface of the mold.

公开(公告)号：US20190351588A1

公开(公告)日：2019-11-21

申请号：US16391341

申请日：2019-04-23

申请人： FUJIFILM Corporation

发明人： Yoshiki SAKAZAKI ,  Kenichiro TAMAKI ,  Toshihiro USA ,  Ikuo TAKANO

IPC分类号： B29C39/26 ,  B29C39/02

摘要： Provided are a mold case that prevents deformation of a microneedle array, and a manufacturing method of a microneedle array. The problems are solved by the manufacturing method of a microneedle array including: a filling step of filling needle-like recessed portions of a mold having flexibility and having a plurality of the needle-like recessed portions on a front surface, with a liquid material; and a drying step of drying the liquid material in a state where the mold filled with the liquid material is stored in the mold case which causes an edge portion of the mold to be sandwiched between the lid and the pedestal.