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公开(公告)号：US20190351204A1
公开(公告)日：2019-11-21
申请号：US16391338
申请日：2019-04-23
Applicant: FUJIFILM Corporation
Inventor： Yoshiki SAKAZAKI , Ikuo TAKANO , Satoshi WAKAMATSU , Keio OKANO , Kenichiro TAMAKI
Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.
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公开(公告)号：US20180222088A1
公开(公告)日：2018-08-09
申请号：US15940985
申请日：2018-03-30
Applicant: FUJIFILM Corporation
Inventor： Shotaro OGAWA , Kenichiro TAMAKI
Abstract: Provided is a method of producing a transdermal absorption sheet using an electroforming mold. A method of manufacturing an electroforming mold includes preparing a mold which is a matrix having a recessed pattern, immersing the mold in a degassed pretreatment liquid stored in a pretreatment liquid tank, then applying ultrasound waves generated from an ultrasound oscillator to the recessed pattern of the mold, and filling recessed portions constituting the recessed pattern with the pretreatment liquid. By immersing the mold in an electroforming tank and performing an electroforming treatment, an electroforming mold is manufactured. A mold having a recessed pattern is manufactured from the electroforming mold and a transdermal absorption sheet is produced using the mold.
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公开(公告)号：US20190351588A1
公开(公告)日：2019-11-21
申请号：US16391341
申请日：2019-04-23
Applicant: FUJIFILM Corporation
Inventor： Yoshiki SAKAZAKI , Kenichiro TAMAKI , Toshihiro USA , Ikuo TAKANO
Abstract: Provided are a mold case that prevents deformation of a microneedle array, and a manufacturing method of a microneedle array. The problems are solved by the manufacturing method of a microneedle array including: a filling step of filling needle-like recessed portions of a mold having flexibility and having a plurality of the needle-like recessed portions on a front surface, with a liquid material; and a drying step of drying the liquid material in a state where the mold filled with the liquid material is stored in the mold case which causes an edge portion of the mold to be sandwiched between the lid and the pedestal.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20190070754A1
公开(公告)日：2019-03-07
申请号：US16175850
申请日：2018-10-31
Applicant: FUJIFILM Corporation
Inventor： Shotaro OGAWA , Toshihiro USA , Kenichiro TAMAKI
Abstract: Provided are a production method of a mold having a recessed pattern, and a manufacturing method of a pattern sheet having good accuracy and excellent productivity. The production method of a mold includes: a step of preparing an electroform having a protruding pattern and a mold having a first mold and a second mold forming a cavity; a step of fixing the electroform excluding an end portion of the electroform to the first mold; a clamping step of clamping the electroform excluding the end portion of the electroform and a region of the protruding pattern between the first mold and the second mold to form the cavity; and an injection step of filling the cavity with a resin.
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公开(公告)号：US20210196938A1
公开(公告)日：2021-07-01
申请号：US17202360
申请日：2021-03-16
Applicant: FUJIFILM Corporation
Inventor： Kenichiro TAMAKI
Abstract: Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer (110) on needle-like recess portions (42) of a mold (50) having the needle-like recess portions (42), a step of supplying a polymer layer forming solution (112) to the inside of a step portion (52) of the mold (50), a step of drying the polymer layer forming solution (112) so as to form a polymer layer (114) and a transdermal absorption sheet (120), and a step of peeling off the transdermal absorption sheet (120) from the mold (50). In the step of peeling off, pressing force is applied to a part of the step portion (52) in a second direction (B) opposite to a first direction (A) in which the transdermal absorption sheet (120) is released from the mold (50), and the transdermal absorption sheet (120) is aspirated with a vacuum suction pad (160) from a side opposite to the mold (50) so that the transdermal absorption sheet (120) is peeled off from the mold (50) in the first direction (A).
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公开(公告)号：US20200246602A1
公开(公告)日：2020-08-06
申请号：US16777902
申请日：2020-01-31
Applicant: FUJIFILM Corporation
Inventor： Kenichiro TAMAKI
IPC: A61M37/00
Abstract: Provided are a microneedle array capable of improving the visibility of an appearance inspection, and a manufacturing method of the same.A microneedle array is a microneedle array including: a sheet portion having a first surface and a second surface which oppose each other; and a plurality of needle portions arranged on the first surface of the sheet portion, in which the second surface of the sheet portion is configured by a rough surface having peak portions and valley portions, and an average transmittance of the sheet portion in a wavelength range of 300 nm to 740 nm is 75% or less.
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7.发明申请公开(公告)号：US20210085943A1
公开(公告)日：2021-03-25
申请号：US17019368
申请日：2020-09-14
Applicant: FUJIFILM Corporation
Inventor： Yuka KOBAYASHI , Yoshiki SAKAZAKI , Kenichiro TAMAKI
IPC: A61M37/00
Abstract: The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying.
Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41. Further, provided are the support member 50, a method of producing the microneedle array 120, and a microneedle array unit 300 including a container 310.-
公开(公告)号：US20210023355A1
公开(公告)日：2021-01-28
申请号：US16910067
申请日：2020-06-24
Applicant: FUJIFILM Corporation
Inventor： Kenichiro TAMAKI
IPC: A61M37/00
Abstract: The present invention provides a method of producing a microneedle array with excellent mountability on a container and excellent handleability such as puncture or disposal, a microneedle array, and a microneedle array unit.
Provided are a method of producing a microneedle array including a step of placing a support member which includes a disk portion having a through-hole and a columnar portion formed on a first surface of the disk portion, on a pattern surface of a mold having needle-like depressions, a step of supplying a base material liquid from a side of the first surface of the disk portion and filling the needle-like depressions with the base material liquid, and a drying step of drying the base material liquid to integrally mold a base material layer and the support member; the produced microneedle array; and a microneedle array unit including the microneedle array and a container.
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