公开(公告)号：US20240315970A1

公开(公告)日：2024-09-26

申请号：US18443959

申请日：2024-02-16

申请人： FUJIFILM Corporation

发明人： Shintaro TANABE ,  Masahiko YAMAMOTO ,  Kimihiko SATO ,  Motomasa TAKAHASHI ,  Kazuhiro TSUNA ,  Yasutaka TASAKI ,  Taisuke ENDO ,  Issei DOI ,  Hirofumi FUKUNAGA

IPC分类号： A61K9/127 ,  C07C219/06 ,  C12N15/88

CPC分类号： A61K9/1272 ,  A61K9/1278 ,  C07C219/06 ,  C12N15/88

摘要： An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided.




In the formula, X represents —NR1— or —O—, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group,



groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

公开(公告)号：US20170092434A1

公开(公告)日：2017-03-30

申请号：US15372471

申请日：2016-12-08

申请人： FUJIFILM Corporation

发明人： Kazuhiro TSUNA ,  Kousuke WATANABE ,  Hiroki SUGIURA ,  Tomoaki YOSHIOKA ,  Toshihiro ISE

IPC分类号： H01G9/20 ,  C07F15/00 ,  H01L51/00 ,  C09B57/10

CPC分类号： H01G9/2059 ,  C07F15/0053 ,  C09B23/105 ,  C09B57/10 ,  H01G9/2018 ,  H01G9/2022 ,  H01G9/2027 ,  H01L51/0086 ,  Y02E10/542

摘要： A photoelectric conversion element having an electrically conductive support, a photoconductor layer including an electrolyte, a charge transfer layer including an electrolyte, and a counter electrode, in which the photoconductor layer has semiconductor fine particles carrying a metal complex dye represented by the following Formula (1), and a dye-sensitized solar cell; and a metal complex dye and a dye solution, each of which is used in the photoelectric conversion element and the dye-sensitized solar cell, ML1L2(X)n1.CImY  Formula (1) in the formula, M represents a metal ion, L1 represents a tridentate ligand having a group LV represented by the following Formula (LV-1) or (LV-2); L2 represents a bidentate or tridentate ligand including at least one of aromatic ring groups having a specific sp2 carbon atom to which a substituent is bonded; X represents a monodentate ligand; n1 represents 0 or 1; CI represents a required counterion; and mY represents an integer of 0 to 3, —RV1═RV2—RV31  Formula (LV-1) —C≡C—RV32  Formula (LV-2) in the formulae, RV1 and RV2 each independently represent a nitrogen atom or CRV4, RV4 represents a hydrogen atom or a substituent, RV31 represents a fused polycyclic aromatic ring group or a fused polycyclic heterocyclic group, and RV32 represents a fused polycyclic aromatic ring group or a heteroaryl group.

公开(公告)号：US20240190800A1

公开(公告)日：2024-06-13

申请号：US18434869

申请日：2024-02-07

申请人： FUJIFILM Corporation ,  FUJIFILM Wako Pure Chemical Corporation

发明人： Kazuhiro TSUNA ,  Koichi IWASAKI ,  Kenji WADA

IPC分类号： C07C45/54

CPC分类号： C07C45/54

摘要： Provided is a method for producing 1,3-disubstituted bicyclo[1.1.1]pentane, the method including subjecting [1.1.1]propellane and a 1,2-diketone compound to a photoreaction in a solvent including an acyclic ether solvent having 5 or more carbon atoms to obtain 1,3-disubstituted bicyclo[1.1.1]pentane, in which a reaction solution coexists with a cyclic ether compound.

公开(公告)号：US20210085604A1

公开(公告)日：2021-03-25

申请号：US17112239

申请日：2020-12-04

申请人： FUJIFILM Corporation

发明人： Shintaro TANABE ,  Masahiko YAMAMOTO ,  Kimihiko SATO ,  Motomasa TAKAHASHI ,  Kazuhiro TSUNA ,  Yasutaka TASAKI ,  Taisuki ENDO ,  Issei DOI ,  Hirofumi FUKUNAGA

IPC分类号： A61K9/127 ,  C12N15/88 ,  C07C219/06

摘要： An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR1— or —O—, R represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

公开(公告)号：US20190295778A1

公开(公告)日：2019-09-26

申请号：US16411019

申请日：2019-05-13

申请人： FUJIFILM Corporation

发明人： Kazuhiro TSUNA ,  Kousuke WATANABE ,  Katsumi KOBAYASHI

IPC分类号： H01G9/20 ,  C09B57/10 ,  C07D495/04 ,  H01L51/00 ,  C07D409/14

摘要： A photoelectric conversion element including an electrically conductive support, a photoconductor layer including an electrolyte, a charge transfer layer including an electrolyte, and a counter electrode, in which the photoconductor layer has semiconductor fine particles carrying a metal complex dye represented by Formula (I). Also disclosed are a dye-sensitized solar cell; a metal complex dye, a dye solution, and a terpyridine compound or an esterified product thereof: M(LA)(LD)(LX)mX.(CI)mY  Formula (I) wherein M represents a metal ion, LA represents a tridentate ligand represented by Formula (AL-1) as defined herein, LD represents a bidentate or tridentate ligand, at least one of coordinating atoms in LD bonded to the metal ion M is a nitrogen atom, at least one of the coordinating atoms is an anion, LX represents a monodentate ligand, mX represents 0 or 1, CI represents a counterion, and mY represents an integer of 0 to 3:

公开(公告)号：US20240279143A1

公开(公告)日：2024-08-22

申请号：US18434872

申请日：2024-02-07

申请人： FUJIFILM Corporation ,  FUJIFILM Wako Pure Chemical Corporation

发明人： Kazuhiro TSUNA ,  Koichi IWASAKI ,  Kenji WADA

IPC分类号： C07C17/10

CPC分类号： C07C17/10 ,  C07C2602/38

摘要： Provided is a method for producing halogenobicyclo[1.1.1]pentane, including a step (a) of reacting 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane with an organometallic reagent in a solvent including acyclic ether having 5 or more carbon atoms to obtain [1.1.1]propellane, and
a step (b) of reacting the obtained [1.1.1]propellane with halogen in a state in which light having a wavelength of 400 nm or less is shielded to obtain halogenobicyclo[1.1.1]pentane.

公开(公告)号：US20170117099A1

公开(公告)日：2017-04-27

申请号：US15400079

申请日：2017-01-06

申请人： FUJIFILM Corporation

发明人： Kazuhiro TSUNA ,  Kousuke Kanagawa WATANABE ,  Katsumi KOBAYASHI

IPC分类号： H01G9/20 ,  C09B57/10 ,  H01L51/00 ,  C07D409/14 ,  C07D495/04

摘要： A photoelectric conversion element including an electrically conductive support, a photoconductor layer including an electrolyte, a charge transfer layer including an electrolyte, and a counter electrode, in which the photoconductor layer has semiconductor fine particles carrying a metal complex dye represented by Formula (I). Also disclosed are a dye-sensitized solar cell; a metal complex dye, a dye solution, and a terpyridine compound or an esterified product thereof: M(LA)(LD)(LX)mX.(CI)mY  Formula (I) wherein M represents a metal ion, LA represents a tridentate ligand represented by Formula (AL-1) as defined herein, LD represents a bidentate or tridentate ligand, at least one of coordinating atoms in LD bonded to the metal ion M is a nitrogen atom, at least one of the coordinating atoms is an anion, LX represents a monodentate ligand, mX represents 0 or 1, CI represents a counterion, and mY represents an integer of 0 to 3:

公开(公告)号：US20160042875A1

公开(公告)日：2016-02-11

申请号：US14879822

申请日：2015-10-09

申请人： FUJIFILM CORPORATION

发明人： Kohsuke WATANABE ,  Hirotaka SATO ,  Yukio TANI ,  Ryo FUJIWARA ,  Kazuhiro TSUNA ,  Katsumi KOBAYASHI

IPC分类号： H01G9/20 ,  C09B57/10 ,  H01L51/00 ,  C07F15/00

CPC分类号： H01G9/2059 ,  C07F15/0053 ,  C09B57/008 ,  C09B57/10 ,  H01G9/2031 ,  H01L51/0086 ,  Y02E10/542 ,  Y02E10/549

摘要： A photoelectric conversion element has a conductive support, a photoreceptor layer containing an electrolyte, a charge carrier layer containing an electrolyte and a counter electrode, and the photoreceptor layer has semiconductor particles on which a metal complex dye represented by Formula (I) is carried. M1(LA)(LD)(Z1).CI  Formula (I) M1 represents a metal atom; Z1 represents a monodentate ligand; LA represents a tridentate ligand represented by Formula (AL-1); LD represents a bidentate ligand represented by Formula (DL-1); and CI represents a counterion necessary for neutralizing the charge.

摘要翻译： 光电转换元件具有导电性支持体，含有电解质的感光体层，含有电解质的电荷载体层和对置电极，感光体层具有载持由式（I）表示的金属络合染料的半导体粒子。 M1（LA）（LD）（Z1）.CI式（I）M1表示金属原子; Z1表示单齿配体; LA代表由式（AL-1）表示的三齿配体; LD表示由式（DL-1）表示的二齿配体; 并且CI表示中和电荷所必需的抗衡离子。

公开(公告)号：US20240252676A1

公开(公告)日：2024-08-01

申请号：US18434870

申请日：2024-02-07

申请人： FUJIFILM Corporation ,  FUJIFILM Wako Pure Chemical Corporation

发明人： Kazuhiro TSUNA ,  Koichi IWASAKI ,  Kenji WADA

IPC分类号： A61K47/69

CPC分类号： A61K47/6951

摘要： Provided is a production method of an inclusion body of a bicycloalkane compound, the production method including mixing a bicycloalkane compound with a cyclodextrin compound in a mixed solvent of water and an organic solvent.

公开(公告)号：US20180374653A1

公开(公告)日：2018-12-27

申请号：US16118811

申请日：2018-08-31

申请人： FUJIFILM Corporation ,  SHARP KABUSHIKI KAISHA

发明人： Kousuke WATANABE ,  Naoyuki HANAKI ,  Kazuhiro TSUNA ,  Ryohsuke YAMANAKA ,  Atsushi FUKUI ,  Hisayuki UTSUMI ,  Megumi KASAHARA ,  Yuichi ICHINOSE

IPC分类号： H01G9/20 ,  C07F15/00 ,  H01L51/00 ,  C09B57/10

摘要： Provided is a photoelectric conversion element including a supporting substrate, a conductive layer, a power generating layer onto which a metal complex dye is adsorbed, and a counter electrode, in which the conductive layer, the power generating layer, and the counter electrode are laminated in this order on the supporting substrate, some or all of voids provided in each of the power generating layer and the counter electrode contain an electrolyte, an adsorption amount of the metal complex dye is 1.0×10−8 to 1.8×10−7 mol/cm2, and the metal complex dye is represented by a specific formula. Also provided is a photoelectric conversion module including a plurality of the photoelectric conversion elements connected to each other.