公开(公告)号：US20210085604A1

公开(公告)日：2021-03-25

申请号：US17112239

申请日：2020-12-04

Applicant: FUJIFILM Corporation

Inventor： Shintaro TANABE ,  Masahiko YAMAMOTO ,  Kimihiko SATO ,  Motomasa TAKAHASHI ,  Kazuhiro TSUNA ,  Yasutaka TASAKI ,  Taisuki ENDO ,  Issei DOI ,  Hirofumi FUKUNAGA

IPC: A61K9/127 ,  C12N15/88 ,  C07C219/06

Abstract: An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR1— or —O—, R represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

公开(公告)号：US20240315970A1

公开(公告)日：2024-09-26

申请号：US18443959

申请日：2024-02-16

Applicant: FUJIFILM Corporation

Inventor： Shintaro TANABE ,  Masahiko YAMAMOTO ,  Kimihiko SATO ,  Motomasa TAKAHASHI ,  Kazuhiro TSUNA ,  Yasutaka TASAKI ,  Taisuke ENDO ,  Issei DOI ,  Hirofumi FUKUNAGA

IPC: A61K9/127 ,  C07C219/06 ,  C12N15/88

CPC classification number: A61K9/1272 ,  A61K9/1278 ,  C07C219/06 ,  C12N15/88

Abstract: An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided.




In the formula, X represents —NR1— or —O—, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group,



groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

公开(公告)号：US20150045339A1

公开(公告)日：2015-02-12

申请号：US14516337

申请日：2014-10-16

Applicant: FUJIFILM Corporation

Inventor： Masaru TAKASAKI ,  Toshiaki TSUJINO ,  Shintarou TANABE ,  Megumi OOKUBO ,  Kimihiko SATO ,  Atsushi HIRAI ,  Daisuke TERADA ,  Shinsuke INUKI ,  Shinsuke MIZUMOTO

IPC: C07D471/04 ,  C07D401/14 ,  C07D239/48 ,  C07D403/12 ,  C07D413/04 ,  C07D403/14 ,  C07D413/14 ,  C07D405/12 ,  C07D401/06 ,  C07D403/04 ,  C07D417/12 ,  C07D409/12 ,  C07D401/12 ,  C07D413/12

CPC classification number: C07D471/04 ,  A61K31/44 ,  A61K31/505 ,  C07D213/74 ,  C07D239/48 ,  C07D239/49 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: The object is to provide an Fms-like tyrosine kinase 3 (FLT3) inhibitor useful as a therapeutic agent for acute myeloid leukemia (AML). A novel nitrogen-containing heterocyclic compound represented by the general formula [1] or a salt thereof is provided. The compound or a salt thereof of the present invention can be used as an active ingredient of a pharmaceutical composition for a treatment of a disease or condition relating to FLT3, such as acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL).

Abstract translation: 目的是提供可用作急性骨髓性白血病（AML）治疗剂的Fms样酪氨酸激酶3（FLT3）抑制剂。 提供了由通式[1]表示的新型含氮杂环化合物或其盐。 本发明的化合物或其盐可以用作治疗与FLT3有关的疾病或病症的药物组合物的活性成分，例如急性骨髓性白血病（AML）和急性早幼粒细胞白血病（APL）。