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13 条记录 (耗时 0.021 秒)

    COMPOUND OR SALT THEREOF AND LIPID PARTICLES
    1.
    发明申请
    COMPOUND OR SALT THEREOF AND LIPID PARTICLES 有权

    公开(公告)号：US20210085604A1

    公开(公告)日：2021-03-25

    申请号：US17112239

    申请日：2020-12-04

    申请人： FUJIFILM Corporation

    发明人： Shintaro TANABE ,  Masahiko YAMAMOTO ,  Kimihiko SATO ,  Motomasa TAKAHASHI ,  Kazuhiro TSUNA ,  Yasutaka TASAKI ,  Taisuki ENDO ,  Issei DOI ,  Hirofumi FUKUNAGA

    IPC分类号： A61K9/127 ,  C12N15/88 ,  C07C219/06

    摘要： An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR1— or —O—, R represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

    METHOD FOR PRODUCING INDAZOLE COMPOUND, AND INDAZOLE COMPOUND
    3.
    发明申请
    METHOD FOR PRODUCING INDAZOLE COMPOUND, AND INDAZOLE COMPOUND 审中-公开

    公开(公告)号：US20190359590A1

    公开(公告)日：2019-11-28

    申请号：US16537701

    申请日：2019-08-12

    申请人： FUJIFILM Corporation

    发明人： Motomasa TAKAHASHI

    IPC分类号： C07D401/04 ,  C07D231/56

    摘要： An object of the invention is to provide a novel method for producing an indazole compound, by which an indazole compound can be produced without using a reaction reagent that exhibits strong toxicity, and a novel indazole compound. According to the invention, a method for producing an indazole compound, including obtaining an indazole compound or a salt thereof from a diazonium salt prepared from an aniline compound in the presence of a compound represented by the following General Formula (1), is provided. In the formula, R1 represents a hydrogen atom or an alkali metal; R2 represents a hydrogen atom, a hydroxyl group, or the like; and R3 represents a hydrogen atom, a C1-30 alkylcarbonyl group which may have a substituent, or a C6-20 arylcarbonyl group which may have a substituent.

    COMPOUND OR SALT THEREOF AND LIPID PARTICLES
    7.
    发明公开
    COMPOUND OR SALT THEREOF AND LIPID PARTICLES 审中-公开

    公开(公告)号：US20240315970A1

    公开(公告)日：2024-09-26

    申请号：US18443959

    申请日：2024-02-16

    申请人： FUJIFILM Corporation

    发明人： Shintaro TANABE ,  Masahiko YAMAMOTO ,  Kimihiko SATO ,  Motomasa TAKAHASHI ,  Kazuhiro TSUNA ,  Yasutaka TASAKI ,  Taisuke ENDO ,  Issei DOI ,  Hirofumi FUKUNAGA

    IPC分类号： A61K9/127 ,  C07C219/06 ,  C12N15/88

    CPC分类号： A61K9/1272 ,  A61K9/1278 ,  C07C219/06 ,  C12N15/88

    摘要： An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided.




    In the formula, X represents —NR1— or —O—, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group,



    groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.

    METHOD OF PRODUCING NUCLEIC ACID COMPOUND, AND NUCLEIC ACID COMPOUND
    10.
    发明申请
    METHOD OF PRODUCING NUCLEIC ACID COMPOUND, AND NUCLEIC ACID COMPOUND 有权

    公开(公告)号：US20220259255A1

    公开(公告)日：2022-08-18

    申请号：US17679104

    申请日：2022-02-24

    申请人： FUJIFILM CORPORATION

    发明人： Kazuhei KANEKO ,  Motomasa TAKAHASHI

    IPC分类号： C07H21/02 ,  C07H1/00 ,  C07H19/073

    摘要： There are provided a method of producing a nucleic acid compound, in which a nucleic acid compound in which any one of a 3-position or a 5-position of a ribose structure is protected by a structure represented by Formula (1), and the nucleic acid compound. In Formula (1), a ring A represents a condensed polycyclic aromatic hydrocarbon ring or an aromatic heterocyclic ring, YA's each independently represent —OCR2—, —NRCR2—, or —SCR2—, R's each independently represent a hydrogen atom, an alkyl group, an aromatic group, or an aromatic group-substituted alkyl group, k represents an integer of 1 to 5, RA's are each independently an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, at least one aliphatic hydrocarbon group in k pieces of RA's has 12 or more carbon atoms, and the ring A may further have a substituent in addition to YA and RA.