公开(公告)号：US20230125992A1

公开(公告)日：2023-04-27

申请号：US18146464

申请日：2022-12-27

Applicant: FUJIFILM Corporation

Inventor： Yuka KOBAYASHI ,  Yoshiki Sakazaki ,  Kenichiro Tamaki

IPC: A61M37/00

Abstract: A microneedle array unit including a microneedle array having a plurality of needle-like protrusions arranged on one surface thereof, a gripping portion provided on a side opposite to the plurality of needle-like protrusions of the microneedle array, and a container configured to accommodate the microneedle array. The container includes an accommodation portion having an opening, a deformable portion disposed on a side opposite to the opening, and a binding portion provided in the accommodation portion of the deformable portion and bound to the gripping portion of the microneedle array. The deformable portion is deformed by receiving an external force in a direction of the opening and presses the microneedle array through the gripping portion, and the microneedle array is pushed out of the accommodation portion by being pressed, and the deformable portion maintains a deformed state and presses the microneedle array.

公开(公告)号：US20250075163A1

公开(公告)日：2025-03-06

申请号：US18949689

申请日：2024-11-15

Applicant: FUJIFILM Corporation

Inventor： Yuka KOBAYASHI ,  Takashi YAKUSHIJI

IPC: C12M1/42

Abstract: Provided are an electroporation device and an electroporation method, in which electric field concentration is suppressed. The electroporation device of the present invention is an electroporation device which introduces a bioactive substance into a biologically derived material in a suspension containing the biologically derived material and the bioactive substance. The electroporation device includes an electrode pair in which electrodes having electrode surfaces are arranged with the electrode surfaces facing each other, a power supply part which applies a voltage to the electrode pair, and a shielding part which has a higher volume resistivity than a volume resistivity of the suspension. At least a part of the shielding part is disposed in a flow passage between the facing electrode surfaces, and is disposed at a region where a distance from end part planes which are obtained by connecting outer edges of the facing electrode surfaces in a first direction orthogonal to both the facing electrode surfaces is within 2 mm in a second direction orthogonal to the first direction and parallel to the electrode surfaces.

公开(公告)号：US20250012706A1

公开(公告)日：2025-01-09

申请号：US18895402

申请日：2024-09-25

Applicant: FUJIFILM CORPORATION

Inventor： Takashi YAMAMOTO ,  Takayuki NISHI ,  Yuka KOBAYASHI ,  Masataka HASEGAWA

IPC: G01N15/1434 ,  G01N15/01 ,  G01N15/10

Abstract: A flow cell includes: a main body that includes a flow passage through which fluid containing a substance from which physical property data is to be measured flows, and contains a resin; and an optical system which is disposed on a part of a wall surface forming the flow passage and condenses measurement light for the physical property data and of which an emission surface for the measurement light is in contact with the fluid flowing through the flow passage, in which at least a part of an opposite wall surface that is the wall surface facing the optical system and at least a part of a side wall surface that is the wall surface interposed between the opposite wall surface and the optical system are covered with a metal.

公开(公告)号：US20240043874A1

公开(公告)日：2024-02-08

申请号：US18489205

申请日：2023-10-18

Applicant: FUJIFILM Corporation

Inventor： Yuka KOBAYASHI ,  Takashi YAKUSHIJI

IPC: C12N15/87 ,  C12M1/42 ,  C12M1/00 ,  C12N5/10

CPC classification number: C12N15/87 ,  C12M35/02 ,  C12M45/20 ,  C12N5/10

Abstract: Provided is an electric perforating device 10 including a flow passage 20 through which liquid flows, a first electrode 30A that forms a first electric field region 60A in the flow passage 20 by being supplied with a pulse voltage, a second electrode 30B that forms a second electric field region 60B on a downstream side of the first electric field region 60A, which is in the flow passage 20, in a flowing direction of the liquid, by being supplied with a pulse voltage, a cooling portion 40 that forms a cooling region 70, which cools the liquid flowing through the flow passage 20, between the first electric field region 60A and the second electric field region 60B in the flow passage 20, and a voltage output portion 50 that outputs a pulse voltage for forming the first electric field region 60A and the second electric field region 60B.

公开(公告)号：US20210023356A1

公开(公告)日：2021-01-28

申请号：US17070910

申请日：2020-10-14

Applicant: FUJIFILM Corporation

Inventor： Yuka KOBAYASHI ,  Yasuhiro SEKIZAWA

IPC: A61M37/00 ,  B81B1/00 ,  B81C1/00

Abstract: Provided is a method of producing a microneedle array unit which is capable of suppressing damage to a microneedle array. The method of producing a microneedle array unit, including an array preparing step of preparing a microneedle array which includes a sheet and a plurality of needles arranged on one surface of the sheet; a container preparing step of preparing a container which includes an accommodating portion defining an opening and a space for accommodating the microneedle array, and a deformable portion disposed on a side opposite to the opening and integrated with the accommodating portion; an accommodating step of accommodating the microneedle array in the accommodating portion of the container by allowing the other surface of the sheet of the microneedle array and the deformable portion of the container to oppose each other; and a deforming step of deforming an outer surface of the accommodating portion inward, which is positioned between the one surface of the sheet of the microneedle array and the opening of the accommodating portion, to form a protrusion that reduces an area of the opening.

公开(公告)号：US20180326193A1

公开(公告)日：2018-11-15

申请号：US15979412

申请日：2018-05-14

Applicant: FUJIFILM Corporation

Inventor： Yuka KOBAYASHI

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2209/06

Abstract: A micro-needle array unit includes a micro-needle array; a container which accommodates the micro-needle array and includes an accommodating portion having an opening and a protrusion that supports the outer peripheral surface of the micro-needle array, a deformation portion disposed on a side opposite to the opening and integrated with the accommodating portion, and a flange portion integrated with the accommodating portion and brought into contact with the skin; and a lid which seals the opening of the container, in which the deformation portion is deformed and the other surface of the micro-needle array is pressed due to an external force being applied in a direction of the opening, the micro-needle array deforms the protrusions and is pushed to the outside from the accommodating portion by the pressing of the other surface of the micro-needle array, and the deformation portion maintains the deformed state and presses the micro-needle array.

公开(公告)号：US20250020572A1

公开(公告)日：2025-01-16

申请号：US18896944

申请日：2024-09-26

Applicant: FUJIFILM CORPORATION

Inventor： Takayuki NISHI ,  Takashi YAMAMOTO ,  Masataka HASEGAWA ,  Yuka KOBAYASHI

IPC: G01N15/1434

Abstract: A flow cell includes a main body that includes a flow passage through which fluid containing a substance from which physical property data is to be measured flows, and an optical system which is disposed on a part of a wall surface forming the flow passage and condenses measurement light for the physical property data and of which an emission surface for the measurement light in contact with the fluid is a flat surface.

公开(公告)号：US20240138435A1

公开(公告)日：2024-05-02

申请号：US18539156

申请日：2023-12-13

Applicant: FUJIFILM CORPORATION

Inventor： Ryo MATSUNO ,  Yuka KOBAYASHI ,  Yosuke NAKAGAWA

IPC: A23D7/04 ,  A23J3/22

CPC classification number: A23D7/04 ,  A23J3/227

Abstract: Provided are a fat lump composition, including a granular material containing an oil and/or fat; and an edible ionically crosslinkable polymer that is crosslinked with a cation, in which b/a is 2.00 or more, in which in at least one of cross sections of the fat lump composition perpendicular to a longitudinal direction, b is a length of a line having a maximum length between two points, and a is a length of a line having a maximum length among lines perpendicular to the line having the maximum length between the two points, a fat lump mixture, a meat alternative, and a method of producing a fat lump composition.

公开(公告)号：US20210244927A1

公开(公告)日：2021-08-12

申请号：US17243860

申请日：2021-04-29

Applicant: FUJIFILM Corporation

Inventor： Junya YOSHIDA ,  Koki KABATA ,  Yuka KOBAYASHI

IPC: A61M37/00

Abstract: An object of the present invention is to provide a micro-needle array device that can have the needle part sufficiently dissolved. According to the present invention, there is provided a micro-needle array device including: a micro-needle array having a sheet part and a plurality of needle parts existing on the top face of the sheet part; and a pressing member for pressing a surface of the sheet part, the surface being on the opposite side of the surface having the needle parts, wherein the sheet part has a thickness of 0.1 to 0.6 mm, and an area A of a pressing face of the pressing member for pressing the sheet part of the micro-needle array and an area B of a region where the needle parts of the needle array exist, satisfy the formula: 0.3≤A/B≤0.75.

公开(公告)号：US20210085943A1

公开(公告)日：2021-03-25

申请号：US17019368

申请日：2020-09-14

Applicant: FUJIFILM Corporation

Inventor： Yuka KOBAYASHI ,  Yoshiki SAKAZAKI ,  Kenichiro TAMAKI

IPC: A61M37/00

Abstract: The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying.
Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41. Further, provided are the support member 50, a method of producing the microneedle array 120, and a microneedle array unit 300 including a container 310.