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公开(公告)号：US20150238413A1
公开(公告)日：2015-08-27
申请号：US14709644
申请日：2015-05-12
Applicant: FUJIFILM Corporation
Inventor： Aya MOCHIZUKI , Seiji KASAHARA , Yanlong CHE , Shotaro OGAWA
CPC classification number: A61K9/0021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B29C39/24 , B29L2031/7544 , B29L2031/756 , F04C2270/0421
Abstract: A method is provided which enables a drug to be concentrated at needle-like protruding portions and which further allows transdermal-absorption sheets to be manufactured at high production efficiency. The method repeats a step of feeding a drug-containing solution from a liquid feeding apparatus to a mold and filling needle-like recessed portions with the drug-containing solution through a nozzle aligned over the needle-like recessed portions in a state where the nozzle and a front surface of the mold are brought into contact with each other, and a step of moving the liquid feeding apparatus relative to the mold in a state where the nozzle and the front surface of the mold are brought into contact with each other. Thus, the two-dimensionally arranged needle-like recessed portions are filled with the drug-containing solution.
Abstract translation: 提供一种使药物能够以针状突出部分浓缩并且进一步允许以高生产效率制造经皮吸收片材的方法。 该方法重复从液体供给装置向药物供给装置供给药物的溶液的步骤，并且通过在针状凹部上排列的喷嘴，用含药液填充针状凹部，在喷嘴 并且模具的前表面彼此接触，并且在喷嘴和模具的前表面彼此接触的状态下使液体供给装置相对于模具移动的步骤。 因此，二维排列的针状凹部被药物溶液填充。
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2.发明申请FIBER MANUFACTURING METHOD, NON-WOVEN FABRIC MANUFACTURING METHOD, AND FIBER MANUFACTURING EQUIPMENT 审中-公开纤维制造方法，非织造织物制造方法和纤维制造设备公开(公告)号：US20160354964A1
公开(公告)日：2016-12-08
申请号：US15231094
申请日：2016-08-08
Applicant: FUJIFILM Corporation
Inventor： Yukihiro KATAI , Shigehisa SUGIYAMA , Seiji KASAHARA , Yasuhisa SHIMODA , Masahiro ESAKI
CPC classification number: B29C47/0021 , B29B11/04 , B29C47/0014 , B29K2001/12 , B29L2007/008 , D01D5/06 , D01F2/28 , D01F13/02 , D04H1/4258 , D04H1/72 , D04H1/736 , D21H13/02 , Y02P70/627
Abstract: A fiber manufacturing method includes the following steps of: dissolving a polymer in a solvent to obtain a polymer solution; spraying the polymer solution into a liquid heated to a boiling point of the solvent or higher, and evaporating the solvent to precipitate a fibrous polymer in a sealed precipitation tank, the liquid being immiscible with the polymer and the solvent; conveying the precipitated fibrous polymer in a liquid from the precipitation tank; water-rinsing the fibrous polymer conveyed in the liquid in the conveying step in a sealed water-rinsing tank; conveying the water-rinsed fibrous polymer in a liquid from the water-rinsing tank; and cooling and condensing solvent gas that is generated in the spraying step and the water-rinsing step.
Abstract translation: 纤维制造方法包括以下步骤：将聚合物溶解在溶剂中以获得聚合物溶液; 将聚合物溶液喷射到加热到溶剂沸点以上的液体中，蒸发溶剂使纤维聚合物沉淀在密封的沉淀槽中，该液体与聚合物和溶剂不混溶; 将沉淀的纤维聚合物从沉淀槽输送到液体中; 在输送步骤中在密封的水冲洗槽中水洗在液体中输送的纤维聚合物; 从水洗槽输送水冲洗的纤维聚合物液体; 以及在喷雾步骤和水漂洗步骤中产生的冷却和冷凝溶剂气体。
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公开(公告)号：US20170119691A1
公开(公告)日：2017-05-04
申请号：US15403588
申请日：2017-01-11
Applicant: FUJIFILM Corporation
Inventor： Junya YOSHIDA , Seiji KASAHARA , Takayoshi OYAMADA , Yanlong CHE
CPC classification number: A61K9/703 , A61K8/0204 , A61K8/732 , A61K8/735 , A61K9/0021 , A61K38/27 , A61K38/385 , A61K2800/91 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/08 , B29C41/22 , B29C59/005 , B29C59/022 , B29C2059/023 , B29K2995/0056 , B29K2995/0065 , B29L2031/7544
Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.
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公开(公告)号：US20150238434A1
公开(公告)日：2015-08-27
申请号：US14709555
申请日：2015-05-12
Applicant: FUJIFILM Corporation
Inventor： Junya YOSHIDA , Seiji KASAHARA , Takayoshi OYAMADA , Yanlong CHE
IPC: A61K9/70
CPC classification number: A61K9/703 , A61K8/0204 , A61K8/732 , A61K8/735 , A61K9/0021 , A61K38/27 , A61K38/385 , A61K2800/91 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/08 , B29C41/22 , B29C59/005 , B29C59/022 , B29C2059/023 , B29K2995/0056 , B29K2995/0065 , B29L2031/7544
Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.
Abstract translation: 透皮吸收片和透皮吸收片的制造方法包括层叠步骤，通过在载体上形成含有第一透皮吸收材料的下层和含有药物的上层，形成具有粘度差的多层膜，以及 第二透皮吸收材料，并且具有比下层更低的粘度;填充步骤，用经皮吸收材料的溶液填充与倒置的针状突起部分相对应的针状凹部， 相对于由支撑体支撑的多层膜的表面，将二维阵列的凹部排列成多层膜，以使多层膜流动，固化步骤使多层膜的模压力压在多层膜的表面上 以及从模具剥离固化的多层膜的剥离步骤。
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