-
1.发明公开公开(公告)号：US20230251248A1
公开(公告)日：2023-08-10
申请号：US18182227
申请日：2023-03-10
Applicant: FUJIFILM Corporation
Inventor： Yoshihiro ABURAYA , Junya YOSHIDA , Hiroyasu ISHII , Junichi KATADA
IPC: G01N33/543 , B01D69/02 , B01D67/00
CPC classification number: G01N33/543 , B01D69/02 , B01D67/0079
Abstract: There are provided a concentration device that makes it possible to concentrate a sample solution in a short time, a sample solution concentration method using the concentration device to concentrate a sample solution, a sample solution concentration method using the sample solution examination method, and an examination kit including the concentration device and the detection device. The concentration device for concentrating a sample solution which is an aqueous solution containing a high-molecular-weight molecule contained in a biological fluid is a concentration device including a first container containing a super absorbent polymer and a second container, in which a part of the first container is constituted of a discharge unit consisting of a porous membrane having a hole diameter of 0.05 μm or more and 10 μm or less, the super absorbent polymer absorbs a solution contained in the sample solution injected into the first container to generate, in the first container, a sample solution concentrated solution which is a concentrated solution of the sample solution, and the second container recovers the sample solution concentrated solution discharged from the discharge unit.
-
公开(公告)号：US20220080171A1
公开(公告)日：2022-03-17
申请号：US17534599
申请日：2021-11-24
Applicant: FUJIFILM Corporation
Inventor： Junya YOSHIDA , Satoshi YONEYAMA
IPC: A61M37/00
Abstract: An object of the present invention is to provide a micro-needle array unit and a container, to which gas permeability, internal visibility, and sterility are imparted. A micro-needle array unit (1) includes a micro-needle array (40) and a container (10) which accommodates the micro-needle array (40), in which the container (10) includes an accommodating portion (12) having an opening (12A), a claw portion (54) provided in the accommodating portion (12) and supporting an outer peripheral surface (42A) of one surface (42) of the micro-needle array (40), a deformable portion (14) disposed on a side opposite to the opening (12A), a flange portion (16) formed integrally with the accommodating portion (12), and a lid member (30) provided in close contact with the flange portion (16), at least a part of the lid member (30) is formed of a transparent film (32), an inner flange portion (16B) in close contact with the lid member (30) has a groove (20) continuous from the accommodating portion (12) to an outside, and the lid member (30) is in close contact with the inner flange portion (16B) to form a flow path continuous from the accommodating portion (12) to the outside.
-
公开(公告)号：US20210260351A1
公开(公告)日：2021-08-26
申请号：US17244262
申请日：2021-04-29
Applicant: FUJIFILM Corporation
Inventor： Junya YOSHIDA , Koki Kabata , Yuka Kobayashi
IPC: A61M37/00
Abstract: An object of the present invention is to provide a micro-needle array unit that can be miniaturized and can sufficiently puncture the skin even in a case of being pressed by a finger. According to the present invention, provided is a micro-needle array unit including a micro-needle array which has a sheet and a plurality of needles arranged inside an outer peripheral surface of one surface of the sheet; a container which accommodates the micro-needle array and includes an accommodating portion having an opening and protrusions that support the outer peripheral surface of the micro-needle array, a deformable portion disposed on a side opposite to the opening and integrated with the accommodating portion, and a flange portion that is integrated with the accommodating portion and brought into contact with a skin; a lid which seals the opening of the container; and a three-dimensional puncture instrument which has two vertically different areas, in which in a case where an external force applied in a direction of the opening by a smaller area between two vertically different areas of the puncture instrument is received, the deformable portion is deformed, and the other surface of the micro-needle array is pressed, the micro-needle array deforms the protrusions and is pushed out of the accommodating portion due to the pressing of the other surface, and the deformable portion presses the micro-needle array while maintaining a deformed state thereof.
-
公开(公告)号：US20180193256A1
公开(公告)日：2018-07-12
申请号：US15914244
申请日：2018-03-07
Applicant: FUJIFILM Corporation
Inventor： Koki KABATA , Junya YOSHIDA , Takayoshi OYAMADA
CPC classification number: A61K9/0021 , A61K38/00 , A61K38/27 , A61K39/00 , A61K39/145 , A61K39/39 , A61K47/26 , A61K47/36 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/0053
Abstract: An object of the present invention is to provide a microneedle array which is formed of a sheet portion and needles and is capable of achieving high drug efficacy. According to the present invention, provided is a microneedle array including: a sheet portion; and a plurality of needles present on an upper surface of the sheet portion, in which the needle contains a water-soluble polymer and a medicament, the water-soluble polymer occupies 50% by mass or greater of the total solid content of the needle, the water-soluble polymer and the medicament are present at a mass ratio of Formula 1, in a needle tip region which includes a needle tip of each needle and has a height corresponding to 20% of the total height of each needle, and the sheet portion contains a water-soluble polymer. water-soluble polymer:medicament=0.05 to 0.9:1 Formula 1;
-
公开(公告)号：US20230228748A1
公开(公告)日：2023-07-20
申请号：US18181691
申请日：2023-03-10
Applicant: FUJIFILM Corporation
Inventor： Hiroyasu ISHII , Junya YOSHIDA , Yoshihiro ABURAYA
IPC: G01N33/569 , G01N1/40
CPC classification number: G01N33/5695 , G01N1/405 , G01N2469/10
Abstract: There are provided a sample solution concentration method that makes it possible to obtain a sample solution concentrated solution having a desired concentration fold ratio and a sample solution examination method using the sample solution concentration method. The sample solution concentration method includes, in the following order, a sample solution injection step of injecting a sample solution, which is an aqueous solution containing a high-molecular-weight molecule, into a cylinder accommodating a particulate super absorbent polymer, a water absorption step in which water contained in the sample solution injected into the cylinder is absorbed by the super absorbent polymer accommodated in the cylinder to generate a sample solution concentrate which is a concentrate of the sample solution, in the cylinder, a liquid addition step of adding a liquid having an amount smaller than an amount of the sample solution injected into the cylinder in the sample solution injection step, to the sample solution concentrate, and a taking-out step of inserting, into the cylinder, a piston insertable into the cylinder, the piston including a tip part having holes smaller than a particle diameter of the super absorbent polymer after water absorption, to take out a sample solution concentrated solution, which is a concentrated solution of the sample solution, through the holes in the tip part of the piston.
-
Patent Agency Ranking
公开(公告)号：US20220080172A1
公开(公告)日：2022-03-17
申请号：US17535272
申请日：2021-11-24
Applicant: FUJIFILM Corporation
Inventor： Junya YOSHIDA , Satoshi YONEYAMA
IPC: A61M37/00
Abstract: An object of the present invention is to provide a micro-needle array unit and a container, to which gas permeability, internal visibility, and sterility are imparted. A micro-needle array unit (1) includes a micro-needle array (40) and a container (10) which accommodates the micro-needle array (40), in which the container (10) includes an accommodating portion (12) having an opening (12A), a claw portion (54) provided in the accommodating portion (12) and supporting an outer peripheral surface (42A) of one surface (42) of the micro-needle array (40), a deformable portion (14) disposed on a side opposite to the opening (12A), a flange portion (16) formed integrally with the accommodating portion (12), and a lid member (30) provided in close contact with the flange portion (16), at least a part of the lid member (30) is formed of a transparent film (32), and a water vapor permeable antibacterial film (34) is provided on at least a part of the container (10).
-
公开(公告)号：US20210244927A1
公开(公告)日：2021-08-12
申请号：US17243860
申请日：2021-04-29
Applicant: FUJIFILM Corporation
Inventor： Junya YOSHIDA , Koki KABATA , Yuka KOBAYASHI
IPC: A61M37/00
Abstract: An object of the present invention is to provide a micro-needle array device that can have the needle part sufficiently dissolved. According to the present invention, there is provided a micro-needle array device including: a micro-needle array having a sheet part and a plurality of needle parts existing on the top face of the sheet part; and a pressing member for pressing a surface of the sheet part, the surface being on the opposite side of the surface having the needle parts, wherein the sheet part has a thickness of 0.1 to 0.6 mm, and an area A of a pressing face of the pressing member for pressing the sheet part of the micro-needle array and an area B of a region where the needle parts of the needle array exist, satisfy the formula: 0.3≤A/B≤0.75.
-
8.发明公开公开(公告)号：US20230228749A1
公开(公告)日：2023-07-20
申请号：US18181761
申请日：2023-03-10
Applicant: FUJIFILM Corporation
Inventor： Hiroyasu ISHII , Junya YOSHIDA , Yoshihiro ABURAYA
IPC: G01N33/569 , G01N1/40 , G01N33/92 , G01N33/543
CPC classification number: G01N33/5695 , G01N1/405 , G01N33/92 , G01N33/54388
Abstract: There are provided a concentration device for concentrating a sample solution, which makes it possible to obtain a sample solution concentrated solution having a desired concentration fold ratio, a sample solution concentration method using the concentration device, a sample solution concentration method using the sample solution examination method, and an examination kit including the concentration device. The concentration device is a concentration device for concentrating a sample solution which is an aqueous solution containing a high-molecular-weight molecule, the concentration device including a cylinder that accommodates a particulate super absorbent polymer and a piston that is insertable into the cylinder, where the cylinder has, at a bottom part, a liquid holding part for holding a part of the sample solution injected into the cylinder, the super absorbent polymer is accommodated in the cylinder to be in contact with the liquid holding part on the liquid holding part, and the piston includes the tip part having holes smaller than the particle diameter of the super absorbent polymer after water absorption.
-
公开(公告)号：US20170296465A1
公开(公告)日：2017-10-19
申请号：US15486312
申请日：2017-04-13
Applicant: FUJIFILM Corporation
Inventor： Junya YOSHIDA , Ikuo KAWAUCHI , Yasushi MOROHASHI
IPC: A61K9/00 , A61K47/26 , A61K47/36 , A61M37/00 , A61K38/27 , B29C39/02 , B29C39/26 , B29L31/00 , B29K105/00
CPC classification number: A61K9/0021 , A61K38/27 , A61K47/26 , A61K47/36 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061 , B29C39/026 , B29C39/26 , B29K2105/0035 , B29K2105/0058 , B29K2883/00 , B29L2031/00 , B29L2031/7544 , B29L2031/756
Abstract: To provide a microneedle array which includes a sheet and needles, improves transfer of a medicament into the blood, and is capable of achieving high drug efficacy.Provided is a microneedle array including: a sheet; and a plurality of needles present on the upper surface of the sheet, in which the needles contain a water-soluble polymer and a medicament, the sheet contains a water-soluble polymer, and the administration is performed such that 20 μm≦L2≦L−L1 is satisfied, here, L represents the length of a needle, L1 represents the length of a needle tip region, which contains 90% of the total medicament in the microneedle array, from the needle tip, L2 represents the average remaining length of the needle after administration using the microneedle array, and the unit of L, L1, and L2 is μm.
-
公开(公告)号：US20170119691A1
公开(公告)日：2017-05-04
申请号：US15403588
申请日：2017-01-11
Applicant: FUJIFILM Corporation
Inventor： Junya YOSHIDA , Seiji KASAHARA , Takayoshi OYAMADA , Yanlong CHE
CPC classification number: A61K9/703 , A61K8/0204 , A61K8/732 , A61K8/735 , A61K9/0021 , A61K38/27 , A61K38/385 , A61K2800/91 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/08 , B29C41/22 , B29C59/005 , B29C59/022 , B29C2059/023 , B29K2995/0056 , B29K2995/0065 , B29L2031/7544
Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.
-
-
-
-
-
-
-
-
-
Search Results
12
records
(took 0.015 seconds)
