公开(公告)号：US20180193256A1

公开(公告)日：2018-07-12

申请号：US15914244

申请日：2018-03-07

Applicant: FUJIFILM Corporation

Inventor： Koki KABATA ,  Junya YOSHIDA ,  Takayoshi OYAMADA

IPC: A61K9/00 ,  A61K47/36 ,  A61K38/27 ,  A61K39/145 ,  A61K47/26 ,  A61M37/00

CPC classification number: A61K9/0021 ,  A61K38/00 ,  A61K38/27 ,  A61K39/00 ,  A61K39/145 ,  A61K39/39 ,  A61K47/26 ,  A61K47/36 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053

Abstract: An object of the present invention is to provide a microneedle array which is formed of a sheet portion and needles and is capable of achieving high drug efficacy. According to the present invention, provided is a microneedle array including: a sheet portion; and a plurality of needles present on an upper surface of the sheet portion, in which the needle contains a water-soluble polymer and a medicament, the water-soluble polymer occupies 50% by mass or greater of the total solid content of the needle, the water-soluble polymer and the medicament are present at a mass ratio of Formula 1, in a needle tip region which includes a needle tip of each needle and has a height corresponding to 20% of the total height of each needle, and the sheet portion contains a water-soluble polymer. water-soluble polymer:medicament=0.05 to 0.9:1  Formula 1;

公开(公告)号：US20130137190A1

公开(公告)日：2013-05-30

申请号：US13749148

申请日：2013-01-24

Applicant: FUJIFILM Corporation

Inventor： Junichi KATADA ,  Hideyuki KARAKI ,  Takayoshi OYAMADA

IPC: G01N33/543

CPC classification number: G01N33/543 ,  G01N33/558 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.

公开(公告)号：US20230201108A1

公开(公告)日：2023-06-29

申请号：US18154575

申请日：2023-01-13

Applicant: FUJIFILM Corporation ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

Inventor： Takayoshi OYAMADA ,  Toshio SHIMADA ,  Kosuke KAKITA ,  Hiroaki IWATA

IPC: A61K9/00 ,  A61K39/12 ,  A61K47/26 ,  A61K47/36

CPC classification number: A61K9/0021 ,  A61K39/12 ,  A61K47/26 ,  A61K47/36 ,  A61K2039/5252

Abstract: It is an object of the present invention to provide a Japanese encephalitis preventive agent and a Japanese encephalitis vaccine agent, which are capable of imparting sufficient immunity to humans, even if these agents are used at a lower dose than the dose of a Japanese encephalitis vaccine for subcutaneous injection, or at a smaller number of administrations than the number of administrations of a Japanese encephalitis vaccine for subcutaneous injection. According to the present invention, provided is a Japanese encephalitis preventive agent, comprising a microneedle array having a sheet portion and a plurality of needle portions present on the upper surface of the sheet portion, wherein the aforementioned needle portions contain or carry an inactivated Japanese encephalitis virus.

公开(公告)号：US20170014336A1

公开(公告)日：2017-01-19

申请号：US15281325

申请日：2016-09-30

Applicant: FUJIFILM Corporation ,  NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

Inventor： Koji KURUMA ,  Takayoshi OYAMADA ,  Toshio SHIMADA ,  Yoshihiro SAKODA ,  Hiroshi KIDA

IPC: A61K9/00 ,  A61K39/145

CPC classification number: A61K9/0021 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/545 ,  C12N2760/16134 ,  C12N2760/16234

Abstract: Provided is a microneedle. The microneedle array includes a needle portion, which contains an inactivated whole virion influenza vaccine, and a sheet portion. Also provided is an administration method in which the microneedle array is administered and then administered secondly after an interval of equal to or greater than 24 hours and less than 2 months.

Abstract translation: 提供一个微针。 微针阵列包括针部分，其包含灭活的全病毒粒子流感疫苗和片部分。 还提供了一种给药方法，其中施用微针阵列，然后在等于或大于24小时且小于2个月的间隔之后给药。

公开(公告)号：US20170119691A1

公开(公告)日：2017-05-04

申请号：US15403588

申请日：2017-01-11

Applicant: FUJIFILM Corporation

Inventor： Junya YOSHIDA ,  Seiji KASAHARA ,  Takayoshi OYAMADA ,  Yanlong CHE

IPC: A61K9/70 ,  A61K38/38 ,  A61M37/00 ,  B29C59/02 ,  B29C59/00 ,  B29C41/22 ,  A61K38/27 ,  A61K9/00

CPC classification number: A61K9/703 ,  A61K8/0204 ,  A61K8/732 ,  A61K8/735 ,  A61K9/0021 ,  A61K38/27 ,  A61K38/385 ,  A61K2800/91 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61Q19/08 ,  B29C41/22 ,  B29C59/005 ,  B29C59/022 ,  B29C2059/023 ,  B29K2995/0056 ,  B29K2995/0065 ,  B29L2031/7544

Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.

公开(公告)号：US20150238743A1

公开(公告)日：2015-08-27

申请号：US14709640

申请日：2015-05-12

Applicant: FUJIFILM Corporation

Inventor： Yanlong CHE ,  Takayoshi OYAMADA ,  Junya YOSHIDA ,  Shotaro OGAWA

IPC: A61M37/00 ,  B32B37/10

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2207/10 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/424 ,  B29C2033/385 ,  B29L2031/7544 ,  B29L2031/756 ,  B32B3/30 ,  B32B25/20 ,  B32B27/26 ,  B32B27/283 ,  B32B37/025 ,  B32B37/1018 ,  B32B2255/26 ,  B32B2305/00 ,  B32B2307/724 ,  B32B2307/7265

Abstract: A molding compact for forming a transdermal absorption sheet on which a needle-shaped protruding part is arranged is a molding compact that is a laminate of: a first member having a needle-shaped recessed part formed on a front surface thereof, the needle-shaped recessed part being an inverse of the needle-shaped protruding part; a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and a third member provided on a back surface of the second member, the third member being composed of a rigid body. Provided are a molding compact that makes it possible to prevent leakage of a drug-containing solution filled into the needle-shaped recessed part, and a manufacturing method for a transdermal absorption sheet using the molding compact.

Abstract translation: 用于形成其上布置有针状突起部的经皮吸收片的成形体是成型体，该成形体是以下层叠体：第一构件，其具有形成在其前表面上的针状凹部，针状 凹部是针状突出部的倒数; 设置在所述第一构件的后表面上的第二构件，所述第二构件由防水透湿材料构成; 以及设置在所述第二构件的后表面上的第三构件，所述第三构件由刚体构成。 提供一种成型体，其能够防止填充在针状凹部中的药物溶液的泄漏，以及使用该成型体的透皮吸收片的制造方法。

公开(公告)号：US20150238434A1

公开(公告)日：2015-08-27

申请号：US14709555

申请日：2015-05-12

Applicant: FUJIFILM Corporation

Inventor： Junya YOSHIDA ,  Seiji KASAHARA ,  Takayoshi OYAMADA ,  Yanlong CHE

IPC: A61K9/70

CPC classification number: A61K9/703 ,  A61K8/0204 ,  A61K8/732 ,  A61K8/735 ,  A61K9/0021 ,  A61K38/27 ,  A61K38/385 ,  A61K2800/91 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61Q19/08 ,  B29C41/22 ,  B29C59/005 ,  B29C59/022 ,  B29C2059/023 ,  B29K2995/0056 ,  B29K2995/0065 ,  B29L2031/7544

Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.

Abstract translation: 透皮吸收片和透皮吸收片的制造方法包括层叠步骤，通过在载体上形成含有第一透皮吸收材料的下层和含有药物的上层，形成具有粘度差的多层膜，以及 第二透皮吸收材料，并且具有比下层更低的粘度;填充步骤，用经皮吸收材料的溶液填充与倒置的针状突起部分相对应的针状凹部， 相对于由支撑体支撑的多层膜的表面，将二维阵列的凹部排列成多层膜，以使多层膜流动，固化步骤使多层膜的模压力压在多层膜的表面上 以及从模具剥离固化的多层膜的剥离步骤。