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公开(公告)号：US09649281B2
公开(公告)日：2017-05-16
申请号：US14709555
申请日：2015-05-12
Applicant: FUJIFILM Corporation
Inventor： Junya Yoshida , Seiji Kasahara , Takayoshi Oyamada , Yanlong Che
CPC classification number: A61K9/703 , A61K8/0204 , A61K8/732 , A61K8/735 , A61K9/0021 , A61K38/27 , A61K38/385 , A61K2800/91 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/08 , B29C41/22 , B29C59/005 , B29C59/022 , B29C2059/023 , B29K2995/0056 , B29K2995/0065 , B29L2031/7544
Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.
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2.发明授权公开(公告)号：US10052807B2
公开(公告)日：2018-08-21
申请号：US15231094
申请日：2016-08-08
Applicant: FUJIFILM Corporation
Inventor： Yukihiro Katai , Shigehisa Sugiyama , Seiji Kasahara , Yasuhisa Shimoda , Masahiro Esaki
IPC: D01D5/06 , D01D5/11 , D01F2/28 , D01F13/02 , D04H1/4258 , D04H1/72 , D04H1/736 , D21H13/02 , B29C47/00 , B29B11/04 , B29K1/00 , B29L7/00
CPC classification number: B29C48/08 , B29B11/04 , B29C48/05 , B29K2001/12 , B29L2007/008 , D01D5/06 , D01F2/28 , D01F13/02 , D04H1/4258 , D04H1/72 , D04H1/736 , D21H13/02 , Y02P70/627
Abstract: A fiber manufacturing method includes the following steps of: dissolving a polymer in a solvent to obtain a polymer solution; spraying the polymer solution into a liquid heated to a boiling point of the solvent or higher, and evaporating the solvent to precipitate a fibrous polymer in a sealed precipitation tank, the liquid being immiscible with the polymer and the solvent; conveying the precipitated fibrous polymer in a liquid from the precipitation tank; water-rinsing the fibrous polymer conveyed in the liquid in the conveying step in a sealed water-rinsing tank; conveying the water-rinsed fibrous polymer in a liquid from the water-rinsing tank; and cooling and condensing solvent gas that is generated in the spraying step and the water-rinsing step.
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公开(公告)号：US10045936B2
公开(公告)日：2018-08-14
申请号：US14709644
申请日：2015-05-12
Applicant: FUJIFILM Corporation
Inventor： Aya Mochizuki , Seiji Kasahara , Yanlong Che , Shotaro Ogawa
Abstract: A method is provided which enables a drug to be concentrated at needle-like protruding portions and which further allows transdermal-absorption sheets to be manufactured at high production efficiency. The method repeats a step of feeding a drug-containing solution from a liquid feeding apparatus to a mold and filling needle-like recessed portions with the drug-containing solution through a nozzle aligned over the needle-like recessed portions in a state where the nozzle and a front surface of the mold are brought into contact with each other, and a step of moving the liquid feeding apparatus relative to the mold in a state where the nozzle and the front surface of the mold are brought into contact with each other. Thus, the two-dimensionally arranged needle-like recessed portions are filled with the drug-containing solution.
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公开(公告)号：US09987236B2
公开(公告)日：2018-06-05
申请号：US15403588
申请日：2017-01-11
Applicant: FUJIFILM Corporation
Inventor： Junya Yoshida , Seiji Kasahara , Takayoshi Oyamada , Yanlong Che
IPC: A61K9/70 , A61M37/00 , A61K8/73 , A61Q19/08 , A61K8/02 , A61K9/00 , A61K38/27 , A61K38/38 , B29C41/22 , B29C59/00 , B29C59/02 , B29L31/00
CPC classification number: A61K9/703 , A61K8/0204 , A61K8/732 , A61K8/735 , A61K9/0021 , A61K38/27 , A61K38/385 , A61K2800/91 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/08 , B29C41/22 , B29C59/005 , B29C59/022 , B29C2059/023 , B29K2995/0056 , B29K2995/0065 , B29L2031/7544
Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.
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