公开(公告)号：US11007678B2

公开(公告)日：2021-05-18

申请号：US15933573

申请日：2018-03-23

Applicant: FUJIFILM Corporation

Inventor： Shotaro Ogawa ,  Satoshi Chai ,  Kenji Ichikawa ,  Kazunori Komatsu ,  Kozue Ikeda ,  Ryo Hibino

IPC: B29C33/38 ,  B29C33/42 ,  B81C99/00 ,  A61M37/00 ,  B29C43/52 ,  B29C33/40 ,  B29C41/20 ,  B29C41/38 ,  B29C41/42 ,  C25D1/10 ,  B29K101/12 ,  B29L7/00 ,  B29L31/00

Abstract: A production method of a mold includes: preparing a plate precursor having a protruding pattern formed of protrusions in a pattern presence region on a base, and a thermoplastic resin sheet; determining a position at which the plate precursor is to be pressed against the thermoplastic resin sheet by moving the plate precursor and the thermoplastic resin sheet relative to each other; and forming a recessed pattern on the thermoplastic resin sheet by pressing the protrusions of the plate precursor which is heated against the thermoplastic resin sheet at a position where a part of the pattern presence region of the plate precursor excluding the protrusions is separated from a surface of the thermoplastic resin sheet, cooling the plate precursor in a state in where the pressed protrusions and the thermoplastic resin sheet are in contact with each other, and separating the plate precursor from the thermoplastic resin sheet.

公开(公告)号：US10814527B2

公开(公告)日：2020-10-27

申请号：US15940985

申请日：2018-03-30

Applicant: FUJIFILM Corporation

Inventor： Shotaro Ogawa ,  Kenichiro Tamaki

IPC: B29C33/38 ,  B29C33/40 ,  B29C41/02 ,  B29C41/42 ,  C25D1/10 ,  A61K47/36 ,  A61K38/38 ,  A61K9/70 ,  C25D21/04 ,  A61M37/00 ,  A61K9/00 ,  B29C41/36 ,  C25D17/10 ,  B29C33/42 ,  B29C39/02 ,  B29L31/00 ,  B29K105/00 ,  C25D3/12 ,  C25D17/02

Abstract: Provided is a method of producing a transdermal absorption sheet using an electroforming mold. A method of manufacturing an electroforming mold includes preparing a mold which is a matrix having a recessed pattern, immersing the mold in a degassed pretreatment liquid stored in a pretreatment liquid tank, then applying ultrasound waves generated from an ultrasound oscillator to the recessed pattern of the mold, and filling recessed portions constituting the recessed pattern with the pretreatment liquid. By immersing the mold in an electroforming tank and performing an electroforming treatment, an electroforming mold is manufactured. A mold having a recessed pattern is manufactured from the electroforming mold and a transdermal absorption sheet is produced using the mold.

公开(公告)号：US10195768B2

公开(公告)日：2019-02-05

申请号：US15286524

申请日：2016-10-05

Applicant: FUJIFILM Corporation

Inventor： Shotaro Ogawa ,  Aya Mochizuki ,  Atsushi Fujita ,  Toshihiro Usa

IPC: B29C33/38 ,  A61M37/00 ,  B29C33/40 ,  B29C33/42 ,  B29C39/00 ,  B29C39/02 ,  B29C39/24 ,  B29C39/26 ,  B29C39/36 ,  B29C33/44 ,  B29K83/00 ,  B29K105/00 ,  B29L31/00 ,  B29C33/30

Abstract: There is provided a method capable of manufacturing a mold at low cost, and a method of manufacturing a biocompatible pattern sheet by using the mold. The method of manufacturing a mold having a recessed pattern includes the steps of: forming a silicone resin film by applying a silicone resin solution to a surface of a model having a protrusion pattern; defoaming the silicone resin film by reducing the silicone resin film in pressure; forming the mold by heating and curing the silicone resin film while a base plate is in contact with a face of the silicone resin film, the face being opposite to the model; and releasing the mold from the model after releasing the base plate. The method of manufacturing a pattern sheet uses the mold.

公开(公告)号：US10029081B2

公开(公告)日：2018-07-24

申请号：US14709640

申请日：2015-05-12

Applicant: FUJIFILM Corporation

Inventor： Yanlong Che ,  Takayoshi Oyamada ,  Junya Yoshida ,  Shotaro Ogawa

IPC: B32B3/30 ,  A61M37/00 ,  A61K9/00 ,  B32B37/10 ,  B32B37/00 ,  B32B25/20 ,  B32B27/26 ,  B32B27/28 ,  B29C33/38 ,  B29C33/40 ,  B29C33/42 ,  B29L31/00

Abstract: A molding compact for forming a transdermal absorption sheet on which a needle-shaped protruding part is arranged is a molding compact that is a laminate of: a first member having a needle-shaped recessed part formed on a front surface thereof, the needle-shaped recessed part being an inverse of the needle-shaped protruding part; a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and a third member provided on a back surface of the second member, the third member being composed of a rigid body. Provided are a molding compact that makes it possible to prevent leakage of a drug-containing solution filled into the needle-shaped recessed part, and a manufacturing method for a transdermal absorption sheet using the molding compact.

公开(公告)号：US11141887B2

公开(公告)日：2021-10-12

申请号：US16175850

申请日：2018-10-31

Applicant: FUJIFILM Corporation

Inventor： Shotaro Ogawa ,  Toshihiro Usa ,  Kenichiro Tamaki

IPC: B29C33/38 ,  B29C59/02 ,  B29C45/17 ,  B29C45/37 ,  A61M37/00 ,  B29L31/00 ,  C25D1/10 ,  B29C33/40 ,  B29C33/00 ,  B29C33/20

Abstract: Provided are a production method of a mold having a recessed pattern, and a manufacturing method of a pattern sheet having good accuracy and excellent productivity. The production method of a mold includes: a step of preparing an electroform having a protruding pattern and a mold having a first mold and a second mold forming a cavity; a step of fixing the electroform excluding an end portion of the electroform to the first mold; a clamping step of clamping the electroform excluding the end portion of the electroform and a region of the protruding pattern between the first mold and the second mold to form the cavity; and an injection step of filling the cavity with a resin.

公开(公告)号：US10045936B2

公开(公告)日：2018-08-14

申请号：US14709644

申请日：2015-05-12

Applicant: FUJIFILM Corporation

Inventor： Aya Mochizuki ,  Seiji Kasahara ,  Yanlong Che ,  Shotaro Ogawa

IPC: A61K9/00 ,  A61M37/00 ,  B29C39/24 ,  B29L31/00

Abstract: A method is provided which enables a drug to be concentrated at needle-like protruding portions and which further allows transdermal-absorption sheets to be manufactured at high production efficiency. The method repeats a step of feeding a drug-containing solution from a liquid feeding apparatus to a mold and filling needle-like recessed portions with the drug-containing solution through a nozzle aligned over the needle-like recessed portions in a state where the nozzle and a front surface of the mold are brought into contact with each other, and a step of moving the liquid feeding apparatus relative to the mold in a state where the nozzle and the front surface of the mold are brought into contact with each other. Thus, the two-dimensionally arranged needle-like recessed portions are filled with the drug-containing solution.