公开(公告)号：US10646127B2

公开(公告)日：2020-05-12

申请号：US15904688

申请日：2018-02-26

Applicant: FUJIFILM Corporation

Inventor： Sho Onozawa ,  Takeshi Unemura ,  Hirotaka Ito

IPC: A61B5/026 ,  A61B6/00 ,  A61B6/03 ,  G16H30/40 ,  G16H50/50

Abstract: A blood flow analysis device includes a blood vessel region extraction unit that extracts a blood vessel region from a three-dimensional medical image of a subject including a blood vessel, and a blood flow simulation unit that obtains a line resistance by multiplying a resistance value corresponding to a branch blood vessel branching out of the blood vessel region by a surface area of each of preset sections into which the blood vessel region is divided in an extension direction, generates a vascular network model by applying the line resistance to each node of a surface of the blood vessel region, and performs simulation of a blood flow by using the vascular network model.

公开(公告)号：US12067713B2

公开(公告)日：2024-08-20

申请号：US17181651

申请日：2021-02-22

Applicant: FUJIFILM Corporation

Inventor： Sohichiro Nakamura ,  Ryusuke Osaki ,  Sho Onozawa

IPC: G06T7/10 ,  C12N5/071 ,  G06T7/00

CPC classification number: G06T7/0012 ,  C12N5/0608 ,  C12N2506/02 ,  C12N2506/45 ,  G06T2207/30024

Abstract: A determination method of non-destructively and easily determining a state of an aggregate of a plurality of cells formed by three-dimensional culture is provided. A determination method according to the disclosed technology includes generating a phase difference image of an aggregate of a plurality of cells from a hologram obtained by imaging the aggregate, deriving a phase difference amount density by dividing a total phase difference amount that is a value obtained by integrating a phase difference amount of each of a plurality of pixels constituting the phase difference image by a volume of the aggregate, and determining a state of the aggregate on the basis of a time transition of the phase difference amount density.

公开(公告)号：US11893728B2

公开(公告)日：2024-02-06

申请号：US16928974

申请日：2020-07-14

Applicant: FUJIFILM Corporation

Inventor： Sohichiro Nakamura ,  Ryusuke Osaki ,  Sho Onozawa ,  Akihiro Asakura

IPC: G06T7/00 ,  G06T7/62 ,  C12Q1/02 ,  G01N15/06 ,  G01N21/45 ,  G02B21/16 ,  G03H1/04

CPC classification number: G06T7/0012 ,  C12Q1/02 ,  G01N15/06 ,  G01N21/453 ,  G06T7/62 ,  G01N2015/0693 ,  G01N2201/0633 ,  G01N2201/06113 ,  G02B21/16 ,  G03H1/0443 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024

Abstract: Provided is a determination method capable of non-destructively and simply determining a state of a sphere that is an aggregate of a plurality of cells. A phase difference image of a sphere that is an aggregate of a plurality of cells is generated from a hologram obtained by imaging the sphere, and a state of the sphere is determined on the basis of the phase difference image and a shape index value corresponding to a shape of the sphere.

公开(公告)号：US11480920B2

公开(公告)日：2022-10-25

申请号：US17537590

申请日：2021-11-30

Applicant: FUJIFILM Corporation

Inventor： Sohichiro Nakamura ,  Sho Onozawa ,  Ryusuke Osaki

IPC: G03H1/22 ,  G06T5/50 ,  G06T7/00

Abstract: An image processing apparatus includes an acquisition unit that acquires a hologram obtained by imaging a plurality of granules contained within an imaging visual field, a generation unit that generates, from the hologram, phase difference images at positions different from each other in an optical axis direction in a case in which the hologram is captured, a specifying unit that specifies a plurality of image ranges in a direction of a plane intersecting the optical axis direction, which correspond to the plurality of granules, in an averaged image obtained by averaging at least some of the phase difference images, and an extraction unit that extracts the phase difference image at a center position of a corresponding granule in the optical axis direction for each of the plurality of image ranges.

公开(公告)号：US11869181B2

公开(公告)日：2024-01-09

申请号：US17182569

申请日：2021-02-23

Applicant: FUJIFILM Corporation

Inventor： Sohichiro Nakamura ,  Sho Onozawa ,  Ryusuke Osaki

IPC: G06T7/00 ,  G06T7/62 ,  C12Q1/02 ,  G01N21/45 ,  G06F17/18

CPC classification number: G06T7/0012 ,  C12Q1/02 ,  G01N21/453 ,  G06F17/18 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024

Abstract: A determination method of non-destructively and easily determining a state of an aggregate of a plurality of cells formed by three-dimensional culture is provided. A determination method according to the disclosed technology includes generating a phase difference image of an aggregate of a plurality of cells from a hologram obtained by imaging the aggregate, deriving a first index value that indicates a randomness of an array of a phase difference amount in a plurality of pixels constituting the phase difference image, and determining a state of the cells constituting the aggregate on the basis of the first index value.

公开(公告)号：US20220253016A1

公开(公告)日：2022-08-11

申请号：US17729267

申请日：2022-04-26

Applicant: FUJIFILM Corporation

Inventor： Yuta MURAKAMI ,  Ryusuke Osaki ,  Sho Onozawa ,  Sohichiro Nakamura

IPC: G03H1/08 ,  C12N5/0735

Abstract: There is provided a method including generating a phase contrast image of an aggregate of a pluripotent stem cell from a hologram in which the aggregates is captured; deriving a phase contrast amount density obtained by dividing a total phase contrast amount which is a value obtained by integrating a phase contrast amount of each of a plurality of pixels that constitute the phase contrast image, by a volume of the aggregate; and sorting the pluripotent stem cell based on the phase contrast amount density.