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    PREPARATION, MEMBER FOR PREPARATION, AND METHODS FOR MANUFACTURING THESE
    1.
    发明申请
    PREPARATION, MEMBER FOR PREPARATION, AND METHODS FOR MANUFACTURING THESE 审中-公开

    公开(公告)号：US20190017046A1

    公开(公告)日：2019-01-17

    申请号：US16144475

    申请日：2018-09-27

    Applicant: FUJIFILM Corporation

    Inventor： Hayato MIYOSHI ,  Toshihide YOSHITANI ,  Tadanori YAMADA

    IPC: C12N15/11 ,  A61K47/42 ,  A61K47/64 ,  C08J3/24 ,  C07K14/435

    Abstract: Objects of the present invention are to provide a preparation, which satisfies both a sufficient drug carrying amount and a preferred decomposition rate, and a method for manufacturing the preparation and to provide a member for a preparation used in the preparation of the present invention described above and a method for manufacturing the member. According to the present invention, there are provided a preparation containing a crosslinked substance of an anionic polypeptide and a cationic, polypeptide and a cationic drug; a method for manufacturing the preparation including a freezing step, a drying step, a crosslinking step, and a drug adding step; a member for a preparation formed of a crosslinked substance of an anionic polypeptide and a cationic polypeptide; and a method for manufacturing the member for a preparation.

    MEDIUM FOR CULTURING HEPATOCYTE, METHOD OF PRODUCING HEPATOCYTE, AND HEPATOCYTE
    3.
    发明申请
    MEDIUM FOR CULTURING HEPATOCYTE, METHOD OF PRODUCING HEPATOCYTE, AND HEPATOCYTE 有权

    公开(公告)号：US20220228112A1

    公开(公告)日：2022-07-21

    申请号：US17707215

    申请日：2022-03-29

    Applicant: FUJIFILM Corporation

    Inventor： Yusuke MORI ,  Tadanori YAMADA

    IPC: C12N5/071

    Abstract: An object of the present invention is to provide a medium with which hepatocytes can be cultured while a metabolic function thereof is maintained, a method of producing a hepatocyte using the above medium, and the hepatocyte that is obtained by the above method. According to the present invention, there is provided a medium for culturing a hepatocyte, containing one or more of a ROCK inhibitor, nicotinamide, and an analogous substance of the nicotinamide, in which a content of a serum component is less than 5% by volume, a content of an EGF receptor activating factor is less than 1 ng/mL, and a content of an ALK inhibitor is less than 0.1 μmol/L.

    METHOD FOR SEPARATING MEGAKARYOCYTES AND PLATELETS AND INSTRUMENT FOR SEPARATING MEGAKARYOCYTES AND PLATELETS
    6.
    发明申请
    METHOD FOR SEPARATING MEGAKARYOCYTES AND PLATELETS AND INSTRUMENT FOR SEPARATING MEGAKARYOCYTES AND PLATELETS 审中-公开

    公开(公告)号：US20200002675A1

    公开(公告)日：2020-01-02

    申请号：US16570626

    申请日：2019-09-13

    Applicant: FUJIFILM Corporation

    Inventor： Toshiki TAKEI ,  Tadanori YAMADA

    IPC: C12N5/078 ,  C12M1/00 ,  B01L3/00 ,  A61M1/02

    Abstract: An object of the present invention is to provide a method for efficiently separating megakaryocytes and platelets produced from the megakaryocytes, and an instrument for efficiently separating megakaryocytes and platelets produced from the megakaryocytes. According to the present invention, a method for separating megakaryocytes and platelets, including a contact step of bringing a culture solution that contains at least megakaryocytes into contact with a substrate coated with a biocompatible polymer that adheres to the megakaryocytes via at least one of a VLA-4 integrin or a VLA-5 integrin; a culture step of culturing the megakaryocytes to produce platelets before and/or after the contact step; and a recovery step of recovering the culture solution after the contact step and the culture step is provided.

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