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公开(公告)号:US20240124389A1
公开(公告)日:2024-04-18
申请号:US18495200
申请日:2023-10-26
Applicant: FUJIFILM Corporation
Inventor: Shintaro TANABE , Tatsuya NITABARU , Mashiko YAMAMOTO , Hirofumi FUKUNAGA , Naoto NAKAMURA , Noriyuki KASAGI , Taisuke ENDO , Keiko SUZUKI
IPC: C07C229/26 , A61K9/127 , C07C229/28
CPC classification number: C07C229/26 , A61K9/127 , C07C229/28
Abstract: An object of present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles and pharmaceutical composition using the compound or a salt thereof, which can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided.
In the formula, each symbol has a meaning defined in the present specification.-
公开(公告)号:US20160168139A1
公开(公告)日:2016-06-16
申请号:US15052252
申请日:2016-02-24
Applicant: FUJIFILM Corporation
Inventor: Yohei KUBO , Makoto ANDO , Hidehiko TANAKA , Shuhei OSAKA , Takuya MATSUMOTO , Hiyoku NAKATA , Daisuke TERADA , Tatsuya NITABARU
IPC: C07D413/14 , C07D409/14 , C07D498/08 , C07D491/048 , C07D411/14 , C07D498/04 , C07D405/14 , C07D491/052 , C07D411/04 , C07D409/04 , C07D405/04
CPC classification number: C07D413/14 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D411/04 , C07D411/14 , C07D417/14 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/107 , C07D498/04 , C07D498/08
Abstract: There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)
Abstract translation: 提供由通式[1A]表示的吗啉衍生物或其盐。 (式中,环A表示通式[I]表示的环; *表示键合位置,Z 2表示CH等,Z1表示CR 6等,R 6表示氢原子等; X 1表示 CHR 7等; R 7表示氢原子等; X 2表示CH 2等; R 1和R 2相同或不同,R 1和R 2各自表示氢原子等; R 3, R 4和R 5彼此相同或不同,R 3,R 4和R 5各自表示氢原子,NR a R b等; R a和R b分别表示氢原子,C 1-8烷基 可以具有取代基的基团等)
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