公开(公告)号：US20240124389A1

公开(公告)日：2024-04-18

申请号：US18495200

申请日：2023-10-26

Applicant: FUJIFILM Corporation

Inventor： Shintaro TANABE ,  Tatsuya NITABARU ,  Mashiko YAMAMOTO ,  Hirofumi FUKUNAGA ,  Naoto NAKAMURA ,  Noriyuki KASAGI ,  Taisuke ENDO ,  Keiko SUZUKI

IPC: C07C229/26 ,  A61K9/127 ,  C07C229/28

CPC classification number: C07C229/26 ,  A61K9/127 ,  C07C229/28

Abstract: An object of present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles and pharmaceutical composition using the compound or a salt thereof, which can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided.




In the formula, each symbol has a meaning defined in the present specification.

公开(公告)号：US20160168139A1

公开(公告)日：2016-06-16

申请号：US15052252

申请日：2016-02-24

Applicant: FUJIFILM Corporation

Inventor： Yohei KUBO ,  Makoto ANDO ,  Hidehiko TANAKA ,  Shuhei OSAKA ,  Takuya MATSUMOTO ,  Hiyoku NAKATA ,  Daisuke TERADA ,  Tatsuya NITABARU

IPC: C07D413/14 ,  C07D409/14 ,  C07D498/08 ,  C07D491/048 ,  C07D411/14 ,  C07D498/04 ,  C07D405/14 ,  C07D491/052 ,  C07D411/04 ,  C07D409/04 ,  C07D405/04

CPC classification number: C07D413/14 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D411/04 ,  C07D411/14 ,  C07D417/14 ,  C07D491/048 ,  C07D491/052 ,  C07D491/056 ,  C07D491/107 ,  C07D498/04 ,  C07D498/08

Abstract: There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)

Abstract translation: 提供由通式[1A]表示的吗啉衍生物或其盐。 （式中，环A表示通式[I]表示的环; *表示键合位置，Z 2表示CH等，Z1表示CR 6等，R 6表示氢原子等; X 1表示 CHR 7等; R 7表示氢原子等; X 2表示CH 2等; R 1和R 2相同或不同，R 1和R 2各自表示氢原子等; R 3， R 4和R 5彼此相同或不同，R 3，R 4和R 5各自表示氢原子，NR a R b等; R a和R b分别表示氢原子，C 1-8烷基 可以具有取代基的基团等）